scholarly journals Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents

2012 ◽  
Vol 5 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Armin Raznahan ◽  
Yohan Lee ◽  
Catherine Vaituzis ◽  
Lan Tran ◽  
Susan Mackie ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Children And Adolescents ◽  
Allelic Variation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Risk Gene ◽  
Autism Spectrum Disorder Risk ◽  
Disorder Risk

scholarly journals Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes

Neuroscience ◽  
2010 ◽  
Vol 168 (3) ◽  
pp. 797-810 ◽  
Author(s):  
K.L. Eagleson ◽  
M.C. Gravielle ◽  
L.J. Schlueter McFadyen-Ketchum ◽  
S.J. Russek ◽  
D.H. Farb ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gabaa Receptor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Receptor Subunit ◽  
Risk Gene ◽  
Autism Spectrum Disorder Risk ◽  
Disorder Risk

scholarly journals Developmental Language Disorder and Autism: Commonalities and Differences on Language

2021 ◽  
Vol 11 (5) ◽  
pp. 589
Author(s):  
Natasa Georgiou ◽  
George Spanoudis
Keyword(s):  
Autism Spectrum Disorder ◽  
Language Impairment ◽  
Language Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Developmental Language Disorder ◽  
Typically Developing Children ◽  
Autism Group ◽  
Developmental Conditions

Language and communication deficits characterize both autism spectrum disorder and developmental language disorder, and the possibility of there being a common profile of these is a matter of tireless debate in the research community. This experimental study addresses the relation of these two developmental conditions in the critical topic of language. Α total of 103 children (79 males, 24 females) participated in the present study. Specifically, the study’s sample consisted of 40 children with autism, 28 children with developmental language disorder, and 35 typically developing children between 6 and 12 years old. All children completed language and cognitive measures. The results showed that there is a subgroup inside the autism group of children who demonstrate language difficulties similar to children with developmental language disorder. Specifically, two different subgroups were derived from the autism group; those with language impairment and those without. Both autism and language-impaired groups scored lower than typically developing children on all language measures indicating a common pathology in language ability. The results of this study shed light on the relation between the two disorders, supporting the assumption of a subgroup with language impairment inside the autism spectrum disorder population. The common picture presented by the two developmental conditions highlights the need for further research in the field.

Functional changes during visuo-spatial working memory in autism spectrum disorder: 2-year longitudinal functional magnetic resonance imaging study

Autism ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 639-652 ◽  
Author(s):  
Vanessa M Vogan ◽  
Benjamin R Morgan ◽  
Mary Lou Smith ◽  
Margot J Taylor
Keyword(s):  
Autism Spectrum Disorder ◽  
Neural Activity ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Typically Developing Children ◽  
Functional Changes

This study examined functional changes longitudinally over 2 years in neural correlates associated with working memory in youth with and without autism spectrum disorder, and the impact of increasing cognitive load. We used functional magnetic resonance imaging and a visuo-spatial 1-back task with four levels of difficulty. A total of 14 children with autism spectrum disorder and 15 typically developing children (ages 7–13) were included at baseline and followed up approximately 2 years later. Despite similar task performance between groups, differences were evident in the developmental trajectories of neural responses. Typically developing children showed greater load-dependent activation which intensified over time in the frontal, parietal and occipital lobes and the right fusiform gyrus, compared to those with autism spectrum disorder. Children with autism spectrum disorder showed minimal age-related changes in load-dependent activation, but greater longitudinal load-dependent deactivation in default mode network compared to typically developing children. Results suggest inadequate modulation of neural activity with increasing cognitive demands in children with autism spectrum disorder, which does not mature into adolescence, unlike their typically developing peers. Diminished ability for children with autism spectrum disorder to modulate neural activity during this period of maturation suggests that they may be more vulnerable to the increasing complexity of social and academic demands as they progress through adolescence than their peers.

Memory enhancements from active control of learning in children with autism spectrum disorder

Autism ◽  
2020 ◽  
Vol 24 (8) ◽  
pp. 1995-2007
Author(s):  
Valentina Fantasia ◽  
Douglas B. Markant ◽  
Giovanni Valeri ◽  
Nicholas Perri ◽  
Azzurra Ruggeri
Keyword(s):  
Autism Spectrum Disorder ◽  
Active Learning ◽  
Active Control ◽  
Learning Experience ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Inclusive Learning ◽  
Active Condition

Previous research with typically developing children and adults shows that active control of the learning experience leads to enhanced episodic memory, as compared with conditions lacking this control. The present study investigates whether similar advantages can be found in children with autism spectrum disorder. In this study, 6–12-year-old autistic children ( N = 29) participated in a simple memory game on a touchscreen tablet, in which they were asked to remember 64 objects presented in four blocks of 16. In two of the blocks, children could decide the order and pacing of study (active condition), whereas in the other two blocks, they passively observed the active study decisions of a previous participant (yoked condition). We found that recognition memory was more accurate for objects studied in the active compared with the yoked condition, even after a week-long delay. The magnitude of the effect was comparable with that obtained in previous studies with typically developing children and adults, suggesting a robustness for the benefits of active learning that goes beyond what previously hypothesized, extending to special populations. We discuss how these findings may help develop pedagogical interventions that leverage the active learning approach to promote inclusive learning. Lay abstract Research with adults and typically developing children has shown that being able to actively control their learning experience, that is, to decide what to learn, when, and at what pace, can boost learning in a variety of contexts. In particular, previous research has shown a robust advantage of active control for episodic memory as compared with conditions lacking this control. In this article, we explore the potential of active control to improve learning of 6- to 12-year-old children diagnosed with autism spectrum disorder. We presented them with a simple memory game on a touchscreen tablet, in which children were asked to recall as many of the presented objects as possible. For half of the objects, children could decide the order and pacing of study (active condition); for the other half, they passively observed the study decisions of a previous participant (yoked condition). We found that recognition memory was more accurate when children could actively control the order, pace, and frequency of the study experience, even after a week-long delay. We discuss how teachers and educators might promote active learning approaches in educational and pedagogical applications to support inclusive learning.

scholarly journals Object-directed imitation in autism spectrum disorder is differentially influenced by motoric task complexity, but not social contextual cues

Autism ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 199-211 ◽  
Author(s):  
Lacey Chetcuti ◽  
Kristelle Hudry ◽  
Megan Grant ◽  
Giacomo Vivanti
Keyword(s):  
Autism Spectrum Disorder ◽  
Task Complexity ◽  
Children With Autism ◽  
Social Motivation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Motor Execution ◽  
Typically Developing Children ◽  
Socially Responsive

We examined the role of social motivation and motor execution factors in object-directed imitation difficulties in autism spectrum disorder. A series of to-be-imitated actions was presented to 35 children with autism spectrum disorder and 20 typically developing children on an Apple® iPad® by a socially responsive or aloof model, under conditions of low and high motor demand. There were no differences in imitation performance (i.e. the number of actions reproduced within a fixed sequence), for either group, in response to a model who acted socially responsive or aloof. Children with autism spectrum disorder imitated the high motor demand task more poorly than the low motor demand task, while imitation performance for typically developing children was equivalent across the low and high motor demand conditions. Furthermore, imitative performance in the autism spectrum disorder group was unrelated to social reciprocity, though positively associated with fine motor coordination. These results suggest that difficulties in object-directed imitation in autism spectrum disorder are the result of motor execution difficulties, not reduced social motivation.

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