scholarly journals Talaromyces marneffei fungemia after travel to China in a Canadian patient with AIDS

2020 ◽  
Vol 192 (4) ◽  
pp. E92-E95
Author(s):  
Mara Waters ◽  
Alina Beliavsky ◽  
Kevin Gough
Keyword(s):  
Talaromyces Marneffei ◽  
Canadian Patient

scholarly journals The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Harshini Weerasinghe ◽  
Hayley E. Bugeja ◽  
Alex Andrianopoulos
Keyword(s):  
Pathogenic Fungi ◽  
Host Cells ◽  
Microbial Pathogens ◽  
Mammalian Host ◽  
Host Immune System ◽  
Nucleotide Exchange ◽  
Phagocytic Cells ◽  
Macrophage Infection ◽  
Bar Domain ◽  
Talaromyces Marneffei

AbstractMicrobial pathogens have evolved many strategies to evade recognition by the host immune system, including the use of phagocytic cells as a niche within which to proliferate. Dimorphic pathogenic fungi employ an induced morphogenetic transition, switching from multicellular hyphae to unicellular yeast that are more compatible with intracellular growth. A switch to mammalian host body temperature (37 °C) is a key trigger for the dimorphic switch. This study describes a novel gene, msgA, from the dimorphic fungal pathogen Talaromyces marneffei that controls cell morphology in response to host cues rather than temperature. The msgA gene is upregulated during murine macrophage infection, and deletion results in aberrant yeast morphology solely during growth inside macrophages. MsgA contains a Dbl homology domain, and a Bin, Amphiphysin, Rvs (BAR) domain instead of a Plekstrin homology domain typically associated with guanine nucleotide exchange factors (GEFs). The BAR domain is crucial in maintaining yeast morphology and cellular localisation during infection. The data suggests that MsgA does not act as a canonical GEF during macrophage infection and identifies a temperature independent pathway in T. marneffei that controls intracellular yeast morphogenesis.

A norbisabolane and an arabitol benzoate from Talaromyces marneffei, an endophytic fungus of Epilobium angustifolium

Fitoterapia ◽  
2021 ◽  
pp. 104948
Author(s):  
Zhong-Duo Yang ◽  
Xu-Dong Zhang ◽  
Xing Yang ◽  
Xiao-Jun Yao ◽  
Zong-Mei Shu
Keyword(s):  
Endophytic Fungus ◽  
Talaromyces Marneffei ◽  
Epilobium Angustifolium

scholarly journals HIV-negative case of Talaromyces marneffei pulmonary infection with a TSC2 mutation

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110167
Author(s):  
Qian Shen ◽  
Lingyan Sheng ◽  
Jianying Zhou
Keyword(s):  
Pulmonary Infection ◽  
Pathogenic Fungus ◽  
Critical Role ◽  
Lavage Fluid ◽  
Tsc2 Gene ◽  
Current Case ◽  
Negative Patient ◽  
Talaromyces Marneffei ◽  
Negative Case ◽  
Hiv Negative

Talaromyces marneffei is a rare dimorphic pathogenic fungus that can induce severe infections in human immunodeficiency virus (HIV)-infected patients. However, such infections have also been reported in non-HIV hosts. This current case report describes a very rare case of a T. marneffei pulmonary infection in an HIV-negative patient with a mutation in the tuberous sclerosis complex subunit 2 ( TSC2) gene. A 24-year-old male patient presented with cough and expectoration for 6 months. Computed tomography showed multiple ground-glass opacities and cystic and cavitated lesions in both lungs. Next generation sequencing (NGS) of the bronchoalveolar lavage fluid was performed to confirm T. marneffei pulmonary infection. The results were further verified using bronchoscopy specimen cultures. This was an HIV-negative patient without a travel history to endemic zones and his blood exon sequencing results showed a mutation in the TSC2 gene. To date, he has recovered well with voriconazole therapy. In summary, patients with TSC2 mutations that induce bronchopulmonary dysplasia may be potential hosts for T. marneffei. Early and timely diagnosis is important for improving prognosis. NGS plays a critical role in the diagnosis of T. marneffei pulmonary infection.

scholarly journals Differences between Mental Disorders of French Canadians and British Canadians

1974 ◽  
Vol 19 (3) ◽  
pp. 247-257 ◽  
Author(s):  
H. B. M. Murphy
Keyword(s):  
Social Relationships ◽  
Psychomotor Retardation ◽  
Thought Disorder ◽  
Blue Collar ◽  
French Canadian ◽  
French Canadians ◽  
Two Cultures ◽  
The Past ◽  
The Two Cultures ◽  
Canadian Patient

A series of studies over the past decade has shown that Canadians of British origin differ from Canadians of French origin with respect to the symptomatology, frequency, course and probably the treatability of mental disorder. French Canadian schizophrenics exhibit more concern with real or imaginary disturbances of social relationships, whereas British Canadian schizophrenics and alcoholics alike exhibit a greater disregard for such relationships and for the support that goes with them. French Canadian depressives have a greater tendency towards psychomotor retardation and somatic concerns, whereas British Canadian depressives show a greater concern with guilt feelings, obsessiveness, and greater signs of thought disorder. First hospitalizations are proportionately more frequent among British Canadians than among French Canadians in the white-collar strata, but the reverse is true in the blue-collar. The British Canadians have the higher incidence of organic disorders, but the French Canadians of the functional ones. When patients are sent to mental hospital the British Canadians tend to achieve earlier discharge than the French Canadians, but when treatment is given in an outpatient clinic there is some evidence that the French Canadians show the better recovery rate. Connections are suggested between these findings and more general differences between the two cultures and it is suggested that clinicians may be able to put such knowledge to practical use. In particular, it is suggested that attention to maintaining social ties is more important for the French Canadian patient than for the British Canadian who conversely requires more attention to be paid to his intra-psychic ties.

scholarly journals Talaromikosis Marneffei

2019 ◽  
Vol 12 (2) ◽  
pp. 72
Author(s):  
Sem S. Surja ◽  
Robiatul Adawiyah ◽  
Retno Wahyuningsih
Keyword(s):  
Endemic Area ◽  
Clinical Manifestations ◽  
Its Region ◽  
Clinical Suspicion ◽  
Cross Wall ◽  
Respiratory Disorder ◽  
Fungal Culture ◽  
Talaromyces Marneffei ◽  
Mycotic Disease ◽  
Histopathology Examination

Talaromycosis marneffei is a mycotic disease caused by Talaromyces marneffei which primarily infectimmunocompromised patient. This disease is endemic in Southeast Asia, and Indonesia consider as endemic area dueto a case of tourist who got the infection after visiting Indonesia. Diagnosis was made based on clinical suspicion withlaboratory confirmation. Clinical manifestations are not specific, such as fever, anemia, weight loss, lymphadenopathy,hepatomegaly, splenomegaly, respiratory disorder, and cutaneous manifestation. Histopathology and culture are themost common examination performed for diagnosis. In histopathology examination, fungi appear as fission arthroconidiacells which shape round to oval, with cross wall formation inside or outside macrophage and histiocyte. Thermaldimorphism characteristic can be observed in fungal culture. Fungi grows as mold at 25oC-30oC and as yeast at 37oC.Definitive identification of T. marneffei was done by molecular examination using primers derived from ITS region asprimary marker and beta tubulin region as secondary marker. Talaromyces marneffei is sapronosis, that transmitted viainhalation of conidia from environment.

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