scholarly journals Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model

2021 ◽  
Vol 9 (22) ◽  
Author(s):  
Tracey Ollewagen ◽  
Yigael S. L. Powrie ◽  
Kathryn H. Myburgh ◽  
Carine Smith
Keyword(s):  
Skeletal Muscle ◽  
Regenerative Capacity ◽  
Rheumatoid Cachexia

scholarly journals Slow-Adhering Stem Cells Derived from Injured Skeletal Muscle Have Improved Regenerative Capacity

2011 ◽  
Vol 179 (2) ◽  
pp. 931-941 ◽  
Author(s):  
Xiaodong Mu ◽  
Guosheng Xiang ◽  
Christopher R. Rathbone ◽  
Haiying Pan ◽  
Ian H. Bellayr ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Regenerative Capacity

scholarly journals Systemic cell therapy for muscular dystrophies

2020 ◽  
Author(s):  
C. Rosanne M. Ausems ◽  
Baziel G.M. van Engelen ◽  
Hans van Bokhoven ◽  
Derick G. Wansink
Keyword(s):  
Skeletal Muscle ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Muscle Cell ◽  
Adult Stem Cells ◽  
Current Status ◽  
Muscular Dystrophies ◽  
Optimal Dosage ◽  
Regenerative Capacity ◽  
Advantages And Disadvantages

AbstractThe intrinsic regenerative capacity of skeletal muscle makes it an excellent target for cell therapy. However, the potential of muscle tissue to renew is typically exhausted and insufficient in muscular dystrophies (MDs), a large group of heterogeneous genetic disorders showing progressive loss of skeletal muscle fibers. Cell therapy for MDs has to rely on suppletion with donor cells with high myogenic regenerative capacity. Here, we provide an overview on stem cell lineages employed for strategies in MDs, with a focus on adult stem cells and progenitor cells resident in skeletal muscle. In the early days, the potential of myoblasts and satellite cells was explored, but after disappointing clinical results the field moved to other muscle progenitor cells, each with its own advantages and disadvantages. Most recently, mesoangioblasts and pericytes have been pursued for muscle cell therapy, leading to a handful of preclinical studies and a clinical trial. The current status of (pre)clinical work for the most common forms of MD illustrates the existing challenges and bottlenecks. Besides the intrinsic properties of transplantable cells, we discuss issues relating to cell expansion and cell viability after transplantation, optimal dosage, and route and timing of administration. Since MDs are genetic conditions, autologous cell therapy and gene therapy will need to go hand-in-hand, bringing in additional complications. Finally, we discuss determinants for optimization of future clinical trials for muscle cell therapy. Joined research efforts bring hope that effective therapies for MDs are on the horizon to fulfil the unmet clinical need in patients. Graphical abstract

Adaptive stretch-shortening contractions: diminished regenerative capacity with aging

2008 ◽  
Vol 33 (6) ◽  
pp. 1181-1191 ◽  
Author(s):  
Brent A. Baker ◽  
Melinda S. Hollander ◽  
Robert R. Mercer ◽  
Michael L. Kashon ◽  
Robert G. Cutlip
Keyword(s):  
Skeletal Muscle ◽  
Tibialis Anterior Muscle ◽  
Recovery Period ◽  
Muscle Performance ◽  
Muscle Adaptation ◽  
Regenerative Capacity ◽  
Age Related ◽  
Old Rats ◽  
Shortening Contractions ◽  
Muscle Remodeling

This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.

scholarly journals Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

2019 ◽  
Vol 163 ◽  
pp. 481-492 ◽  
Author(s):  
Harshini Neelakantan ◽  
Camille R. Brightwell ◽  
Ted G. Graber ◽  
Rosario Maroto ◽  
Hua-Yu Leo Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Small Molecule ◽  
Regenerative Capacity ◽  
Muscle Stem Cells

scholarly journals Fetal Skeletal Muscle Progenitors Have Regenerative Capacity after Intramuscular Engraftment in Dystrophin Deficient Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63016 ◽  
Author(s):  
Hiroshi Sakai ◽  
Takahiko Sato ◽  
Hidetoshi Sakurai ◽  
Takuya Yamamoto ◽  
Kazunori Hanaoka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Regenerative Capacity ◽  
Deficient Mice

scholarly journals Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

2016 ◽  
Vol 22 (8) ◽  
pp. 897-905 ◽  
Author(s):  
Laura Lukjanenko ◽  
M Juliane Jung ◽  
Nagabhooshan Hegde ◽  
Claire Perruisseau-Carrier ◽  
Eugenia Migliavacca ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Regenerative Capacity ◽  
Cell Niche

Regenerative capacity of skeletal muscle

2005 ◽  
Vol 18 (5) ◽  
pp. 548-553 ◽  
Author(s):  
Janine Ehrhardt ◽  
Jennifer Morgan
Keyword(s):  
Skeletal Muscle ◽  
Regenerative Capacity
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