scholarly journals Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

2016 ◽  
Vol 22 (8) ◽  
pp. 897-905 ◽  
Author(s):  
Laura Lukjanenko ◽  
M Juliane Jung ◽  
Nagabhooshan Hegde ◽  
Claire Perruisseau-Carrier ◽  
Eugenia Migliavacca ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Regenerative Capacity ◽  
Cell Niche

scholarly journals Telocytes within human skeletal muscle stem cell niche

2011 ◽  
Vol 15 (10) ◽  
pp. 2269-2272 ◽  
Author(s):  
Florina M. Bojin ◽  
Oana I. Gavriliuc ◽  
Mirabela I. Cristea ◽  
Gabriela Tanasie ◽  
Carmen S. Tatu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Human Skeletal Muscle ◽  
Muscle Stem Cell ◽  
Cell Niche

scholarly journals Visualization of the Skeletal Muscle Stem Cell Niche in Fiber Bundles

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Svenja C. Schüler ◽  
Simon Dumontier ◽  
Jonathan Rigaux ◽  
C. Florian Bentzinger
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Fiber Bundles ◽  
Muscle Stem Cell ◽  
Cell Niche

Stem Cell Review Series: Aging of the skeletal muscle stem cell niche

Aging Cell ◽  
2008 ◽  
Vol 7 (4) ◽  
pp. 590-598 ◽  
Author(s):  
Suchitra D. Gopinath ◽  
Thomas A. Rando
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Muscle Stem Cell ◽  
Stem Cell Review ◽  
Cell Niche

scholarly journals mRNA-Expression of ERα, ERβ, and PR in Clonal Stem Cell Cultures Obtained from Human Endometrial Biopsies

2011 ◽  
Vol 11 ◽  
pp. 1762-1769 ◽  
Author(s):  
A. N. Schüring ◽  
J. Braun ◽  
S. Wüllner ◽  
L. Kiesel ◽  
M. Götte
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Adult Stem Cells ◽  
Direct Stimulation ◽  
Regenerative Capacity ◽  
Endometrial Stem Cells ◽  
Proliferation And Differentiation ◽  
Clonal Cultures ◽  
Cell Niche

Background. Proliferation and differentiation of the endometrium are regulated by estrogen and progesterone. The enormous regenerative capacity of the endometrium is thought to be based on the activity of adult stem cells. However, information on endocrine regulatory mechanisms in human endometrial stem cells is scarce. In the present study, we investigated the expression of ERα, ERβ, and PR in clonal cultures of human endometrial stem cells derived from transcervical biopsies.Methods. Endometrial tissue of 11 patients was obtained by transcervical biopsy. Stromal cell suspensions were plated at clonal density and incubated for 15 days. Expression of ERα, ERβand PR was determined by qPCR prior to and after one cloning round, and normalized to 18 S rRNA expression.Results. Expression of ERαand ERβwas downregulated by 64% and 89%, respectively ( and ). In contrast, PR was not significantly downregulated, due to a more heterogenous expression pattern.Conclusions. Culture of human endometrial stroma cells results in a downregulation of ERαand ERβ, while expression of PR remained unchanged in our patient collective. These results support the hypothesis that stem cells may not be subject to direct stimulation by sex steroids, but rather by paracrine mechanisms within the stem cell niche.

Telocytes: An Emerging Component of Stem Cell Niche Microenvironment

2021 ◽  
pp. 002215542110254
Author(s):  
Irene Rosa ◽  
Mirca Marini ◽  
Mirko Manetti
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Scientific Literature ◽  
Cell Junctions ◽  
Supporting Cells ◽  
Pathological Conditions ◽  
Cell Niche ◽  
Cytoplasmic Processes ◽  
Unique Relationship

Telocytes (TCs) are newly identified interstitial cells characterized by thin and long cytoplasmic processes, called telopodes, which exhibit a distinctive moniliform shape and, often, a sinuous trajectory. Telopodes typically organize in intricate networks within the stromal space of most organs, where they communicate with neighboring cells by means of specialized cell-to-cell junctions or shedding extracellular vesicles. Hence, TCs are generally regarded as supporting cells that help in the maintenance of local tissue homeostasis, with an ever-increasing number of studies trying to explore their functions both in physiological and pathological conditions. Notably, TCs appear to be part of stem cell (SC) niches in different organs, including the intestine, skeletal muscle, heart, lung, and skin. Indeed, growing evidence points toward a possible implication of TCs in the regulation of the activity of tissue-resident SCs and in shaping the SC niche microenvironment, thus contributing to tissue renewal and repair. Here, we review how the introduction of TCs into the scientific literature has deepened our knowledge of the stromal architecture focusing on the intestine and skeletal muscle, two organs in which the recently unveiled unique relationship between TCs and SCs is currently in the spotlight as potential target for tissue regenerative purposes.

scholarly journals Skeletal Muscle Stem Cell Niche from Birth to Old Age

2020 ◽  
Author(s):  
Madalina-Gabriela Barbu ◽  
Andreea-Elena Boboc ◽  
Lidia Filip ◽  
Oana-Larisa Bugnar ◽  
Dragos Cretoiu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Satellite Cells ◽  
Stem Cell Niche ◽  
Myogenic Differentiation ◽  
Cell Types ◽  
Undifferentiated Cells ◽  
Cell Niche ◽  
Therapeutic Tools

Stem cells are defined as undifferentiated cells that are able to unlimitedly renew themselves within controlled conditions and to differentiate into a multitude of mature cell types. Skeletal muscle stem cells, represented predominantly by satellite cells, show a variable capability of self-renewal and myogenic differentiation. They were found to be involved not only in the growth of myofibers during neonatal and juvenile life but also in the regeneration of skeletal muscles after an injury. The microenvironment in which stem cells are nourished and maintained dormant preceding division and differentiation is known as “niche.” The niche consists of myofibers, which are believed to modulate the active/inactive state of the stem cells, extracellular matrix, neural networks, blood vessels, and a multitude of soluble molecules. It was observed that changes in the composition of the niche have an impact on the stem cell functions and hierarchy. Furthermore, it seems that its layout is variable throughout the entire life, translating into a decrease in the regenerative capacity of satellite cells in aged tissues. The scope of this chapter is to provide a detailed view of the changes that occur in the skeletal stem cell niche during life and to analyze their implications on tissue regeneration. Future studies should focus on developing new therapeutic tools for diseases involving muscle atrophy.

Suppressing Hippo signaling in the stem cell niche promotes skeletal muscle regeneration

Stem Cells ◽  
2021 ◽  
Vol 39 (6) ◽  
pp. 737-749
Author(s):  
Qi Liu ◽  
Su Pan ◽  
Shijie Liu ◽  
Sui Zhang ◽  
James T. Willerson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Muscle Regeneration ◽  
Stem Cell Niche ◽  
Skeletal Muscle Regeneration ◽  
Hippo Signaling ◽  
Cell Niche

scholarly journals Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Shantisree Sandeepani Rayagiri ◽  
Daniele Ranaldi ◽  
Alexander Raven ◽  
Nur Izzah Farhana Mohamad Azhar ◽  
Olivier Lefebvre ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Basal Lamina ◽  
Stem Cell Niche ◽  
Self Renewal ◽  
Muscle Stem Cell ◽  
Cell Niche
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