scholarly journals Involvement of PAR2 in platelet‐derived growth factor receptor‐α‐positive cell proliferation in the colon of diabetic mice

2021 ◽  
Vol 9 (21) ◽  
Author(s):  
Yu‐Jia Li ◽  
Jun‐Ping Ao ◽  
Xu Huang ◽  
Hong‐Li Lu ◽  
Han‐Yue Fu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Diabetic Mice

scholarly journals PAR2 Involved in Colonic Platelet-Derived Growth Factor Receptor-Α-Positive Cell Proliferation in Diabetic Mice

2021 ◽  
Vol 06 (02) ◽  
Author(s):  
Yu-Jia L ◽  
Jun-Ping A ◽  
Huang X ◽  
Hong-Li L ◽  
Han-Yue F ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Diabetic Mice

scholarly journals Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation

1999 ◽  
Vol 274 (23) ◽  
pp. 16619-16628 ◽  
Author(s):  
Sachiko Miyake ◽  
Karen P. Mullane-Robinson ◽  
Nancy L. Lill ◽  
Patrice Douillard ◽  
Hamid Band
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Negative Regulation ◽  
Platelet Derived Growth Factor ◽  
Dependent Cell

scholarly journals Evidence for glutathione involvement in platelet-derived growth-factor-mediated signal transduction

1997 ◽  
Vol 324 (3) ◽  
pp. 791-796 ◽  
Author(s):  
Stefania RIGACCI ◽  
Teresa IANTOMASI ◽  
Patrizia MARRACCINI ◽  
Andrea BERTI ◽  
Maria Teresa VINCENZINI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Receptor Activation ◽  
Platelet Derived Growth Factor ◽  
Glutathione Depletion ◽  
Physiological Processes ◽  
Buthionine Sulphoximine ◽  
Precise Relationship

Recent studies show that glutathione, while being involved in the well-known physiological processes of amino acid transport and detoxification, can also play a part in cell proliferation events. Cell treatment with l-buthionine sulphoximine, which causes glutathione depletion, is accompanied by a decrease in cell proliferation. At present no precise relationship between this thiol and any critical intermediate of the mitogenic cascade has been proved. In this study, conducted on NIH/3T3 murine fibroblasts, we demonstrate a strict correlation between glutathione levels and platelet-derived growth-factor-receptor activation in response to stimulation and cell proliferation. The receptor autophosphorylation is severely impaired at low glutathione cellular levels. The interaction of glutathione with this growth-factor receptor in vivo, while being rather specific, is complex and may involve both cytosolic and extracellular receptor domains.

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