scholarly journals Time‐restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Christopher J. Kotarsky ◽  
Nathaniel R. Johnson ◽  
Sean J. Mahoney ◽  
Steven L. Mitchell ◽  
Regina L. Schimek ◽  
...  
2020 ◽  
Vol 9 (2) ◽  
pp. 522
Author(s):  
Ulrike H. Mitchell ◽  
Bruce Bailey ◽  
Patrick J. Owen

Aerobic exercise training has many known cardiovascular benefits that may promote healthy aging. It is not known if long-term aerobic exercise training is also associated with structural benefits (e.g., lower fat mass, higher areal bone mineral density (BMD) and greater muscle mass). We evaluated these parameters in middle-aged long-term endurance runners compared to sex-, age-, height-, and weight-matched non-running controls. Total and regional lean and fat mass and areal BMD were assessed by dual-energy X-ray absorptiometry. Sagittal magnetic resonance images captured the cross-sectional area and thickness of the lumbar multifidus. Runners (n = 10; all male) had a mean (standard deviation; SD) age of 49 (4) years, height of 178.9 (4.9) cm, weight of 67.8 (5.8) kg, body mass index (BMI) of 21.4 (1.4) kg/m2 and had been running 82.6 (27.9) km/week for 23 (13) years. Controls (n = 9) had a mean (SD) age of 51 (5) years, height of 176.0 (5.1) cm, weight of 72.8 (7.1) kg, and BMI of 23.7 (2.1) kg/m2. BMI was greater in controls (p = 0.010). When compared to controls on average, runners had a 10 percentage-point greater total body lean mass than controls (p = 0.001) and 14% greater trunk lean mass (p = 0.010), as well as less total body (8.6 kg; p < 0.001), arm (58%; p = 0.002), leg (52%; p < 0.001), trunk (73%; p < 0.001), android (91%; p < 0.001), and gynoid fat mass (64%; p < 0.001). No differences were observed between groups for BMD outcomes or multifidus size. These results underscore the benefits of endurance running to body composition that carry over to middle-age.


Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Julie Holden ◽  
Damon Swift ◽  
Neil Johannsen ◽  
Conrad Earnest ◽  
Timothy Church

Hypothesis: Weight gained in response to aerobic exercise represents an increase in lean mass. Methods: Participants from the exercise group (n=68) of the Inflammation and Exercise (INFLAME) study had fat mass, lean mass, and weight measured at baseline and at follow-up. Fat mass and lean mass were measured using DXA. Changes in lean mass and fat mass were quantified across tertiles of weight change in the exercise training group and were analyzed using generalized linear models with adjustment for baseline value. Results: are presented as least squares means with 95% confidence intervals. Results: Overall, participants exhibited a mean (range) weight change of –0.73 kg (–9.00, 7.00; n=68) following exercise training. Tertiles of mean (range) weight change were: tertile 1 (most weight loss) –3.40 kg (–9.00,–1.50; n=23), tertile 2 (some weight loss) –0.70 kg (–1.30, –0.10; n=22), and tertile 3 (weight gain) 1.93 kg (0, 7.00; n=23). For those in tertile 3, we observed a significant increase (p<0.0001) in lean mass of 0.91 kg (95% CI, 0.48, 1.34) compared to those who lost weight −0.85 kg (−1.28,−0.42) in tertile 1 and −0.52 kg (−0.97,−0.08) in tertile 2. However, no significant difference in lean mass change was seen between the two weight loss tertiles. We also observed a significant increase in fat mass in participants who gained weight (tertile 3) 1.07 kg (0.41, 1.73) while those who lost the most weight (tertile 1) −2.55 kg (−3.21,−1.89) had a significant decrease in fat mass. Participants who experienced some weight loss (tertile 2) showed no significant change in fat mass, −0.24 kg (−0.91, 0.44). Conclusion: Weight gained with aerobic exercise training cannot be attributed to increased lean mass only. Our findings suggest that adults who gained weight with exercise showed significant increases in both fat and lean mass.


2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Shenghui Wu ◽  
Kyung-Shin Park ◽  
Joseph B. McCormick

We investigated the effect of exercise training on body composition change in women. Nineteen Mexican-American and 18 Korean premenopausal overweight/obese women were randomized into one of the following groups: control, low-intensity training group (LI), and high-intensity training group (HI). Subjects completed 12 weeks of training at 50–56% maximal oxygen consumption (LI) or 65–70% maximal oxygen consumption (HI). Body composition components were measured at baseline and after training using dual-energy X-ray absorptiometry for Mexican-Americans, while whole-body composition was measured by the direct segmental multifrequency bioelectrical impedance analysis and abdominal fat was measured by single-slice computed tomography for Koreans. Data were analyzed using mixed-model repeated measures independent of age, ethnicity, and body mass index (BMI). Exercise training showed a significant effect on BMI, fat percentage, fat mass, lean mass, and visceral adipose tissue area. HI significantly decreased fat mass and fat percentage but increased lean mass (all P<0.05). LI significantly reduced BMI, fat mass, fat percentage, and visceral adipose tissue area but increased lean mass (all P<0.05). Exercise training had a beneficial effect on reducing BMI, fat percentage, fat mass, and visceral adipose tissue area but had no effect on increasing lean mass for Mexican-American and Korean premenopausal overweight/obese women.


Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2512
Author(s):  
Mariangela Rondanelli ◽  
Niccolò Miraglia ◽  
Pietro Putignano ◽  
Ignazio Castagliuolo ◽  
Paola Brun ◽  
...  

In animals it has been demonstrated that Saccharomyces boulardii and Superoxide Dismutase (SOD) decrease low-grade inflammation and that S. boulardii can also decrease adiposity. The purpose of this study was to evaluate the effect of a 60-day S. boulardii and SOD supplementation on circulating markers of inflammation, body composition, hunger sensation, pro/antioxidant ratio, hormonal, lipid profile, glucose, insulin and HOMA-IR, in obese adults (BMI 30–35 kg/m2). Twenty-five obese adults were randomly assigned to intervention (8/4 women/men, 57 ± 8 years) or Placebo (9/4 women/men, 50 ± 9 years). Intervention group showed a statistically significant (p < 0.05) decrease of body weight, BMI, fat mass, insulin, HOMA Index and uric acid. Patients in intervention and control groups showed a significant decrease (p < 0.05) of GLP-1. Intervention group showed an increase (p < 0.05) of Vitamin D as well. In conclusion, the 60-day S. boulardii-SOD supplementation in obese subjects determined a significant weight loss with consequent decrease on fat mass, with preservation of fat free mass. The decrease of HOMA index and uric acid, produced additional benefits in obesity management. The observed increase in vitamin D levels in treated group requires further investigation.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 529-529
Author(s):  
Amanda Randolph ◽  
Tatiana Moro ◽  
Adetutu Odejimi ◽  
Blake Rasmussen ◽  
Elena Volpi

Abstract Type 2 Diabetes Mellitus (T2DM) accelerates the incidence and increases the prevalence of sarcopenia in older adults. This suggests an urgent need for identifying effective sarcopenia treatments for older adults with T2DM. It is unknown whether traditional approaches, such as progressive resistance exercise training (PRET), can effectively counteract sarcopenia in older patients with T2DM. To test the efficacy of PRET for the treatment of sarcopenia in older adults with T2DM, 30 subjects (15 T2DM and 15 age- and sex- matched controls) underwent metabolic testing with muscle biopsies before and after a 13-week full-body PRET program. Primary outcome measures included changes in appendicular lean mass, muscle strength, and mixed muscle fractional synthesis rate (FSR). Before PRET, BMI-adjusted appendicular lean mass was significantly lower in the T2DM group (0.7095±0.0381 versus 0.8151±0.0439, p&lt;0.0001). As a result of PRET, appendicular lean mass adjusted for BMI and muscle strength increased significantly in both groups, but to a lesser extent for the T2DM group (p=0.0009) . Preliminary results for FSR (n=25) indicate that subjects with T2DM had lower basal FSR prior to PRET (p=0.0197) . Basal FSR increased significantly in the control group after PRET (p=0.0196), while it did not change in the T2DM group (p=0.3537). These results suggest that in older adults the positive effect of PRET on muscle anabolism and strength is reduced by T2DM . Thus, older adults with T2DM may require more intensive, multimodal and targeted sarcopenia treatment. Funded by NIH R01AG049611 and P30AG024832.


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