scholarly journals Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Vardan T. Karamyan
Keyword(s):  
Vasoactive Peptides

Pharmacological Potential of Exercise and RAS Vasoactive Peptides for Prevention of Diseases

2013 ◽  
Vol 14 (6) ◽  
pp. 459-471 ◽  
Author(s):  
Bernardo Petriz ◽  
Jeeser Almeida ◽  
Ludovico Migliolo ◽  
Octavio Franco
Keyword(s):  
Vasoactive Peptides ◽  
Pharmacological Potential

Biological Function and Chemistry of Endothelin. A Review

1999 ◽  
Vol 64 (8) ◽  
pp. 1211-1252 ◽  
Author(s):  
Jan Hlaváček ◽  
Renáta Marcová
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Biological Function ◽  
Biological Properties ◽  
Structural Basis ◽  
Amino Acid Residues ◽  
Snake Venoms ◽  
Vasoactive Peptides ◽  
Physico Chemical ◽  
Endothelin A

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references.

INDUCTION OF E-SELECTIN BY VASOACTIVE PEPTIDES ON KERATINOCYTES IN VITRO

2000 ◽  
Vol 28 (5) ◽  
pp. A231-A231
Author(s):  
E. Hagi-Pavli ◽  
PM Farthing ◽  
S. Kapas
Keyword(s):  
Vasoactive Peptides

Extracerebral Levels of Circulating Vasoactive Peptides during Migraine Headache

Cephalalgia ◽  
1989 ◽  
Vol 9 (10_suppl) ◽  
pp. 292-293 ◽  
Author(s):  
Peter J. Goadsby ◽  
Lars Edvinsson ◽  
Rolf Ekman
Keyword(s):  
Migraine Headache ◽  
Vasoactive Peptides

Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1

1996 ◽  
Vol 270 (3) ◽  
pp. H857-H868 ◽  
Author(s):  
R. M. Touyz ◽  
J. Fareh ◽  
G. Thibault ◽  
B. Tolloczko ◽  
R. Lariviere ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Agonist ◽  
Dependent Manner ◽  
Induced Responses ◽  
Ang Ii ◽  
Binding Studies ◽  
Vasoactive Peptides ◽  
Adult Cardiomyocytes ◽  
Etb Receptor ◽  
Dose Dependent

Vasoactive peptides may exert inotropic and chronotropic effects in cardiac muscle by modulating intracellular calcium. This study assesses effects of angiotensin II (ANG II) and endothelin-1 (ET-1) on intracellular free calcium concentration ([Ca2+]i) in cultured cardiomyocytes from neonatal and adult rats. [Ca2+]i was measured microphotometrically and by digital imaging using fura 2 methodology. Receptor subtypes through which these agonists induce responses were determined pharmacologically and by radioligand binding studies. ANG II and ET-1 increased neonatal atrial and ventricular cell [Ca2+]i transients in a dose-dependent manner. ANG II (10(-11) to 10(-7) M) failed to elicit [Ca2+]i responses in adult cardiomyocytes, whereas ET-1 increased [Ca2+]i in a dose-dependent manner. The ETA receptor antagonist BQ-123 significantly reduced (P 7< 0.05) ET-1 induced responses, and the ETB receptor agonist IRL-1620 (10(-7) to 10(-5) M) significantly increased (P < 0.05) [Ca2+]i in neonatal and adult cardiomyocytes. ET-1 binding studies demonstrated 85% displacement by BQ-123 and approximately 15% by the ETB receptor agonist sarafotoxin S6c, suggesting a predominance of ETA receptors. Competition binding studies for ANG II failed to demonstrate significant binding on adult ventricular myocytes, indicating the absence or presence of very few ANG II receptors. These data demonstrate that ANG II and ET-1 have stimulatory [Ca2+]i effects on neonatal cardiomyocytes, whereas in adult cardiomyocytes, ANG II-induced effects are insignificant, and only ET-1-induced responses, which are mediated predominantly via ETA receptors, are preserved. Cardiomyocyte responses to vasoactive peptides may thus vary with cardiac development.

Neurogenic modulation and vasoactive peptides in microvascular biology

2008 ◽  
Vol 13 (9) ◽  
pp. 574-574
Author(s):  
S. D. Brain ◽  
A. D. Grant ◽  
C. Tam ◽  
E. Pintér ◽  
A. Starr ◽  
...  
Keyword(s):  
Vasoactive Peptides

scholarly journals Vasomotor Responses of Rat Intracerebral Arterioles to Vasoactive Intestinal Peptide, Substance P, Neuropeptide Y, and Bradykinin

1988 ◽  
Vol 8 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Ralph G. Dacey ◽  
John E. Bassett ◽  
Masakazu Takayasu
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Vessel Diameter ◽  
Cerebral Microcirculation ◽  
Vasoactive Peptides ◽  
Spontaneous Tone ◽  
Ph Dependent ◽  
Dose Dependent

The effect of vasoactive peptides on vascular smooth muscle in the cerebral microcirculation was examined using an isolated intracerebral arteriole preparation. Extraluminally applied vasoactive intestinal peptide (VIP) dilated the spontaneous tone of intracerebral arterioles to 118.9 ± 3.1% of control diameter at pH 7.30, with an EC50 of 7.27 × 10−8 M. Similar degrees of dilation to VIP were seen in vessels preconstricted by changing bath solution to pH 7.60. Substance P had no effect on vessel diameter at pH 7.30. However, in vessels precontracted by pH 7.60, significant dose-dependent dilation was observed with an EC50 of 2.55 × 10−10 M. Neuropeptide constricted intracerebral arterioles to 8l.22 ± 2.7% of control diameter, with an EC50 of 6.23 × 10−10 M. Bradykinin dilated intracerebral arterioles at pH 7.30 and pH 7.60 to 130 ± 3.0% of control diameter. VIP and bradykinin are potent vasodilators of intracerebral arterioles. Neuropeptide Y is a vasoconstrictor. The effect of substance P appeared to be either pH-dependent or dependent on some degree of precontraction by another agonist, but no effect on vessel diameter was seen at pH 7.30.

scholarly journals Effects of perfusion of hCG, PGF2α and vasoactive peptides into the corpus luteum of mares on progesterone and PGF2α secretion

2008 ◽  
Vol 31 (1) ◽  
pp. 6-11
Author(s):  
T. Tsukada ◽  
A.Y. Kojima ◽  
M. Moriyoshi ◽  
M. Koyago ◽  
K. Sato ◽  
...  
Keyword(s):  
Corpus Luteum ◽  
Vasoactive Peptides
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