scholarly journals Local low‐intensity vibration improves healing of muscle injury in mice

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Thomas F. Corbiere ◽  
Timothy J. Koh
Keyword(s):  
Muscle Injury ◽  
Low Intensity ◽  
Low Intensity Vibration

scholarly journals Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Matthew Thompson ◽  
Kali Woods ◽  
Joshua Newberg ◽  
Julia Thom Oxford ◽  
Gunes Uzer
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Simulated Microgravity ◽  
Mechanical Forces ◽  
Cell Level ◽  
Nuclear Entry ◽  
Low Intensity ◽  
Nuclear Shuttling ◽  
Low Intensity Vibration ◽  
Daily Application

AbstractReducing the musculoskeletal deterioration that astronauts experience in microgravity requires countermeasures that can improve the effectiveness of otherwise rigorous and time-expensive exercise regimens in space. The ability of low-intensity vibrations (LIV) to activate force-responsive signaling pathways in cells suggests LIV as a potential countermeasure to improve cell responsiveness to subsequent mechanical challenge. Mechanoresponse of mesenchymal stem cells (MSC), which maintain bone-making osteoblasts, is in part controlled by the “mechanotransducer” protein YAP (Yes-associated protein), which is shuttled into the nucleus in response to cyto-mechanical forces. Here, using YAP nuclear shuttling as a measurement outcome, we tested the effect of 72 h of clinostat-induced simulated microgravity (SMG) and daily LIV application (LIVDT) on the YAP nuclear entry driven by either acute LIV (LIVAT) or Lysophosphohaditic acid (LPA), applied after the 72 h period. We hypothesized that SMG-induced impairment of acute YAP nuclear entry would be alleviated by the daily application of LIVDT. Results showed that while both acute LIVAT and LPA treatments increased nuclear YAP entry by 50 and 87% over the basal levels in SMG-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls. LIVDT, applied in parallel to SMG, restored the SMG-driven decrease in basal nuclear YAP to control levels as well as increased the LPA-induced but not LIVAT-induced YAP nuclear entry over SMG only, counterparts. These cell-level observations suggest that daily LIV treatments are a feasible countermeasure for restoring basal nuclear YAP levels and increasing the YAP nuclear shuttling in MSCs under SMG.

scholarly journals Adaptations of Mouse Skeletal Muscle to Low-Intensity Vibration Training

2013 ◽  
Vol 45 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
JAMES N. MCKEEHEN ◽  
SUSAN A. NOVOTNY ◽  
KRISTEN A. BALTGALVIS ◽  
JARROD A. CALL ◽  
DAVID J. NUCKLEY ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Skeletal Muscle ◽  
Low Intensity ◽  
Vibration Training ◽  
Low Intensity Vibration

scholarly journals Low-intensity treadmill exercise enhances fast recovery from bupivacaine-induced muscle injury in rats

2013 ◽  
Vol 2 (4) ◽  
pp. 157-165
Author(s):  
Kijeong Kim ◽  
Tae-Won Jun ◽  
Hong Kim ◽  
Chang-Ju Kim ◽  
Wook Song
Keyword(s):  
Muscle Injury ◽  
Treadmill Exercise ◽  
Fast Recovery ◽  
Low Intensity

Repair and remodeling of partial-weightbearing, uninstrumented long bone fracture model in mice treated with low intensity vibration therapy

2021 ◽  
Vol 81 ◽  
pp. 105244
Author(s):  
Karl H. Wenger ◽  
Diana Heringer ◽  
Tammilee Lloyd ◽  
Maria S. Johnson ◽  
John D. DesJardins ◽  
...  
Keyword(s):  
Bone Fracture ◽  
Fracture Model ◽  
Long Bone ◽  
Low Intensity ◽  
Vibration Therapy ◽  
Long Bone Fracture ◽  
Low Intensity Vibration

scholarly journals Low intensity vibration of ankle muscles improves balance in elderly persons at high risk of falling

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194720 ◽  
Author(s):  
Nima Toosizadeh ◽  
Jane Mohler ◽  
Vladimir Marlinski
Keyword(s):  
High Risk ◽  
Elderly Persons ◽  
Risk Of Falling ◽  
Low Intensity ◽  
Ankle Muscles ◽  
Low Intensity Vibration

scholarly journals Low-intensity vibration increases cartilage thickness in obese mice

2017 ◽  
Author(s):  
Tee Pamon ◽  
Vincent Bhandal ◽  
Benjamin J. Adler ◽  
M. Ete Chan ◽  
Clinton T. Rubin
Keyword(s):  
Cartilage Thickness ◽  
Obese Mice ◽  
Low Intensity ◽  
Low Intensity Vibration

scholarly journals Low Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity

2020 ◽  
Author(s):  
M Thompson ◽  
K Woods ◽  
J Newberg ◽  
JT Oxford ◽  
G Uzer
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Simulated Microgravity ◽  
Mechanical Forces ◽  
Cell Level ◽  
Nuclear Entry ◽  
Low Intensity ◽  
Nuclear Shuttling ◽  
Low Intensity Vibration ◽  
Daily Application

AbstractReducing the bone deterioration that astronauts experience in microgravity requires countermeasures that can improve the effectiveness of rigorous and time-expensive exercise regimens under microgravity. The ability of low intensity vibrations (LIV) to activate force-responsive signaling pathways in cells suggests LIV as a potential countermeasure to improve cell responsiveness to subsequent mechanical challenge. Mechanoresponse of mesenchymal stem cells (MSC) which maintain bone-making osteoblasts is in part controlled by the “mechanotransducer” protein YAP (Yes-associated protein) which is shuttled into the nucleus in response cyto-mechanical forces. Here, using YAP nuclear shuttling as a measure of MSC mechanoresponse, we tested the effect of 72 hours of simulated microgravity (SMG) and daily LIV application (LIVDT) on the YAP nuclear entry driven by either acute LIV (LIVAT) or Lysophosphohaditic acid (LPA), applied at the end of the 72h period. We hypothesized that SMG-induced impairment of acute YAP nuclear entry will be alleviated by daily application of LIVDT. Results showed that while both acute LIVAT and LPA treatments increased nuclear YAP entry by 50% and 87% over the basal levels in SMG-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls. Daily dosing of LIVDT, applied in parallel to SMG, restored the SMG-driven decrease in basal nuclear YAP to control levels as well as increased the LPA-induced but not LIVAT-induced YAP nuclear entry over the non-LIVDT treated, SMG only, counterparts. These cell level observations suggest that utilizing daily LIV treatments is a feasible countermeasure for increasing the YAP-mediated anabolic responsiveness of MSCs to subsequent mechanical challenge under SMG.

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