scholarly journals Low-intensity vibration increases cartilage thickness in obese mice

2017 ◽  
Author(s):  
Tee Pamon ◽  
Vincent Bhandal ◽  
Benjamin J. Adler ◽  
M. Ete Chan ◽  
Clinton T. Rubin
Keyword(s):  
Cartilage Thickness ◽  
Obese Mice ◽  
Low Intensity ◽  
Low Intensity Vibration

scholarly journals Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Matthew Thompson ◽  
Kali Woods ◽  
Joshua Newberg ◽  
Julia Thom Oxford ◽  
Gunes Uzer
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Simulated Microgravity ◽  
Mechanical Forces ◽  
Cell Level ◽  
Nuclear Entry ◽  
Low Intensity ◽  
Nuclear Shuttling ◽  
Low Intensity Vibration ◽  
Daily Application

AbstractReducing the musculoskeletal deterioration that astronauts experience in microgravity requires countermeasures that can improve the effectiveness of otherwise rigorous and time-expensive exercise regimens in space. The ability of low-intensity vibrations (LIV) to activate force-responsive signaling pathways in cells suggests LIV as a potential countermeasure to improve cell responsiveness to subsequent mechanical challenge. Mechanoresponse of mesenchymal stem cells (MSC), which maintain bone-making osteoblasts, is in part controlled by the “mechanotransducer” protein YAP (Yes-associated protein), which is shuttled into the nucleus in response to cyto-mechanical forces. Here, using YAP nuclear shuttling as a measurement outcome, we tested the effect of 72 h of clinostat-induced simulated microgravity (SMG) and daily LIV application (LIVDT) on the YAP nuclear entry driven by either acute LIV (LIVAT) or Lysophosphohaditic acid (LPA), applied after the 72 h period. We hypothesized that SMG-induced impairment of acute YAP nuclear entry would be alleviated by the daily application of LIVDT. Results showed that while both acute LIVAT and LPA treatments increased nuclear YAP entry by 50 and 87% over the basal levels in SMG-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls. LIVDT, applied in parallel to SMG, restored the SMG-driven decrease in basal nuclear YAP to control levels as well as increased the LPA-induced but not LIVAT-induced YAP nuclear entry over SMG only, counterparts. These cell-level observations suggest that daily LIV treatments are a feasible countermeasure for restoring basal nuclear YAP levels and increasing the YAP nuclear shuttling in MSCs under SMG.

scholarly journals Adaptations of Mouse Skeletal Muscle to Low-Intensity Vibration Training

2013 ◽  
Vol 45 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
JAMES N. MCKEEHEN ◽  
SUSAN A. NOVOTNY ◽  
KRISTEN A. BALTGALVIS ◽  
JARROD A. CALL ◽  
DAVID J. NUCKLEY ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Skeletal Muscle ◽  
Low Intensity ◽  
Vibration Training ◽  
Low Intensity Vibration

scholarly journals PO-034 Effect of Voluntary Exercise on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wenhao Zong ◽  
Yang Liu ◽  
Lulu Dai ◽  
Guijun Dong
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
High Fat Diet ◽  
Wheel Running ◽  
Cartilage Thickness ◽  
Obese Mice ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

Objective To examine the effect of voluntary wheel-running exercise on cartilage morphology of knee osteoarthritis(KOA) in obese mice induced by high-fat diet,and explore the protective role of 4 weeks voluntary wheel-running exercise on KOA,finally providing effective experimental evidence for clinical treatment of knee osteoarthritis. Methods C57BL/6J mice were randomly assigned to the C-Sed group,C-Ex group,HF-Sed group and HF-Ex group.The control groups were fed a control diet(13.5% kcal from fat),and the high-fat groups were fed a high-fat diet(60% kcal from fat).After feeding 8 weeks different diets,the exercise groups were starting running.In order to examine the effect of voluntary wheel-running exercise on cartilage morphology of KOA,the joint of knee were harvested to be fixed,decalcified and embedded in paraffin,and the four-micrometer-thick sections were stained with both HE and toluidine blue . Results After feeding twelve weeks different diets,the body mass of the high-fat diet group mice has a significant increase,which demonstrates that high-fat diet could successfully induce the mice obese.From the results of HE and toluidine blue,in comparison to the C-Sed group,the surface of the knee articular cartilage in the HF-Sed group was not intact and smooth,and the thickness of articular cartilage has a significant decrease（p<0.001）;contrary to the HF-Sed group,the surface of the knee articular cartilage in HF-Ex group was slightly smooth,and there was significant increase in cartilage thickness. Conclusions Four weeks voluntary wheel-running exercise can increase cartilage thickness ,decrease the Mankin’s score and delay the degeneration of knee cartilage in obese mice.To conclude,the short-term wheel-running exercise protects against obesity-induced KOA.

Repair and remodeling of partial-weightbearing, uninstrumented long bone fracture model in mice treated with low intensity vibration therapy

2021 ◽  
Vol 81 ◽  
pp. 105244
Author(s):  
Karl H. Wenger ◽  
Diana Heringer ◽  
Tammilee Lloyd ◽  
Maria S. Johnson ◽  
John D. DesJardins ◽  
...  
Keyword(s):  
Bone Fracture ◽  
Fracture Model ◽  
Long Bone ◽  
Low Intensity ◽  
Vibration Therapy ◽  
Long Bone Fracture ◽  
Low Intensity Vibration

scholarly journals Low intensity vibration of ankle muscles improves balance in elderly persons at high risk of falling

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194720 ◽  
Author(s):  
Nima Toosizadeh ◽  
Jane Mohler ◽  
Vladimir Marlinski
Keyword(s):  
High Risk ◽  
Elderly Persons ◽  
Risk Of Falling ◽  
Low Intensity ◽  
Ankle Muscles ◽  
Low Intensity Vibration

Low-Intensity Swimming Training after Weaning Improves Glucose and Lipid Homeostasis in MSG Hypothalamic Obese Mice

2011 ◽  
Vol 36 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Dionízia Xavier Scomparin ◽  
Sabrina Grassiolli ◽  
Rodrigo Mello Gomes ◽  
Rosana Torrezan ◽  
Júlio Cezar de Oliveira ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Obese Mice ◽  
Swimming Training ◽  
Low Intensity ◽  
Glucose And Lipid Homeostasis
Sign in / Sign up

Export Citation Format

Share Document