scholarly journals The renal transport of hippurate and protein‐bound solutes

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Rohit Kumar ◽  
Avinash Adiga ◽  
Joshua Novack ◽  
Alex Etinger ◽  
Lawrence Chinitz ◽  
...  
Keyword(s):  
Renal Transport

Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats

2021 ◽  
pp. 100406
Author(s):  
Yuichi Ichimura ◽  
Natsumi Kudoh ◽  
Takashi Murabe ◽  
Takumi Akao ◽  
Sho Watanuki ◽  
...  
Keyword(s):  
Indoxyl Sulfate ◽  
Renal Transport ◽  
Inhibitory Effects

scholarly journals Population pharmacokinetic modeling of cefadroxil renal transport in wild-type andPept2knockout mice

Xenobiotica ◽  
2015 ◽  
Vol 46 (4) ◽  
pp. 342-349 ◽  
Author(s):  
Yehua Xie ◽  
Hong Shen ◽  
Yongjun Hu ◽  
Meihua Rose Feng ◽  
David E. Smith
Keyword(s):  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Renal Transport ◽  
Wild Type ◽  
Population Pharmacokinetic Modeling

Effect of Lactate Infusion on Renal Transport of Purine Bases and Oxypurinol

Nephron ◽  
1993 ◽  
Vol 65 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Yumiko Nasako ◽  
Kazuya Higashino
Keyword(s):  
Renal Transport ◽  
Purine Bases ◽  
Lactate Infusion

scholarly journals RENAL TRANSPORT OF PAH AND GLOMERULO-TUBULAR(GT) RETIONSHIPS DURING DEVELOPMENT IN PUPPIES UNINE-PHRECTOMIZED AT BIRTH

1977 ◽  
Vol 11 (4) ◽  
pp. 554-554 ◽  
Author(s):  
Teresa M Mantaring ◽  
Billy S Arant ◽  
J N Etteldorf
Keyword(s):  
Renal Transport

Role of Sodium Ion in Renal Transport of p-Aminohippuratein vitro

1980 ◽  
Vol 21 (2) ◽  
pp. 123
Author(s):  
Yang Saeng Park ◽  
Seung Mook Lee
Keyword(s):  
Sodium Ion ◽  
Renal Transport

Transport of L-proline by luminal membrane vesicles from pars recta of rabbit proximal tubule

1988 ◽  
Vol 254 (5) ◽  
pp. F628-F633
Author(s):  
H. Roigaard-Petersen ◽  
C. Jacobsen ◽  
M. I. Sheikh
Keyword(s):  
Active Site ◽  
Membrane Vesicles ◽  
Rabbit Kidney ◽  
Renal Transport ◽  
High Affinity ◽  
Luminal Membrane ◽  
Transport Studies ◽  
Straight Tubules ◽  
Pars Recta ◽  
Maximal Capacity

The mechanism of renal transport of L-proline by luminal membrane vesicles prepared from proximal straight tubules (pars recta) of rabbit kidney was investigated. The following picture emerges from transport studies: an electrogenic and Na+-requiring system confined to this region of nephron exists for transport of L-proline with a high affinity (Km = 0.16 mM) and low capacity (Vmax = 3.5 nmol.mg protein-1.15 S-1). Lowering the pH from 7.5 to 5.5 increased the affinity (Km lowered from 0.16 mM at pH 7.5 to 0.08 mM at pH 5.5) without changing the maximal capacity of this system. Modification of histidyl residues of the intact luminal membrane vesicles by diethyl-pyrocarbonate (DEP) completely abolished the transient renal accumulation of L-proline. Simultaneous presence of Na+ and L-proline (10 mM) protects against DEP inactivation of renal transport of radioactive L-proline. We propose that a histidyl residue may be at or close to the active site of L-proline transporter in vesicles from the pars recta.

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