Renal Transport of Amino Acids: Membrane Mechanisms1

2015 ◽  
pp. 14-28 ◽  
Author(s):  
H. Murer
Keyword(s):  
Amino Acids ◽  
Renal Transport

THE RENAL TRANSPORT OF AMINO ACIDS IN UNTREATED INFANTS WITH PHENYLKETONURIA

1970 ◽  
Vol 59 (3) ◽  
pp. 241-248 ◽  
Author(s):  
J. BRODEHL ◽  
K. GELLISSEN ◽  
W. P. KAAS
Keyword(s):  
Amino Acids ◽  
Renal Transport

scholarly journals Influence of parathormone on renal transport of amino acids in children

1974 ◽  
Vol 8 (11) ◽  
pp. 894-894
Author(s):  
M Brandis ◽  
J Brodehl ◽  
A Jäkel ◽  
N Liappis
Keyword(s):  
Amino Acids ◽  
Renal Transport

A quantitative histochemical approach to renal transport. I. Aspartate and glutamate

1975 ◽  
Vol 229 (4) ◽  
pp. 1034-1044 ◽  
Author(s):  
AW Chan ◽  
HB Burch ◽  
TR Alvey ◽  
OH Lowry
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Proximal Tubule ◽  
Direct Analysis ◽  
Renal Transport ◽  
Precise Localization ◽  
Transport Activity ◽  
General Applicability ◽  
Freeze Dried ◽  
Thin Limb

Renal transport was studied by direct analysis of specific segments of the nephron for the substance transported. Rats were given inulin plus loads of glutamate or aspartate. Glomeruli, six different identified segments, and patches from thin-limb and papillary areas were dissected from individual nephrons in freeze-dried sections. Large amounts of the amino acid (up to 35 mmol/kg) accumulated in segments in which transport is believed to occur. With subthreshold loads, large amino acid increments were confined to earlier proximal segments. With loads above threshold, increases occurred throughout the proximal tubule. The early convoluted tubule probably has less transport activity than the rest of the proximal tubule. Both dicarboxylic amino acids accumulate in large amount when one is given. Aspartate is probably formed within the tubule after a glutamate load. This new histochemical approach may have general applicability for more precise localization of transport cells, for assessing changes in those cells during transport, and for study of structures inaccessible to micropuncture.

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