scholarly journals Effect of vagus nerve stimulation on blood glucose concentration in epilepsy patients – Importance of stimulation parameters

2019 ◽  
Vol 7 (14) ◽  
Author(s):  
Harald M. Stauss ◽  
Lucienne M. Daman ◽  
Megan M. Rohlf ◽  
Rup K. Sainju
Keyword(s):  
Blood Glucose ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Glucose Concentration ◽  
Vagus Nerve Stimulation ◽  
Blood Glucose Concentration ◽  
Stimulation Parameters

scholarly journals Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion

2020 ◽  
Author(s):  
Elliott W Dirr ◽  
Morgan E Urdaneta ◽  
Yogi Patel ◽  
Richard D Johnson ◽  
Martha Campbell-Thompson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Blood Glucose Concentration ◽  
Electrode Placement ◽  
Visceral Organ ◽  
Organ Systems

The pancreas is a visceral organ with exocrine functions for digestion and endocrine functions for maintenance of blood glucose homeostasis. In pancreatic diseases such as Type 1 diabetes, islets of the endocrine pancreas become dysfunctional and normal regulation of blood glucose concentration ceases. In healthy individuals, parasympathetic signaling to islets via the vagus nerve, triggers release of insulin from pancreatic β-cells and glucagon from α-cells. Using electrical stimulation to augment parasympathetic signaling may provide a way to control pancreatic endocrine functions and ultimately control blood glucose. Historical data suggest that cervical vagus nerve stimulation recruits many visceral organ systems. Simultaneous modulation of liver and digestive function along with pancreatic function provides differential signals that work to both raise and lower blood glucose. Targeted pancreatic vagus nerve stimulation may provide a solution to minimizing off-target effects through careful electrode placement just prior to pancreatic insertion.

scholarly journals Sensitivity Analysis of Vagus Nerve Stimulation Parameters on Acute Cardiac Autonomic Responses: Chronotropic, Inotropic and Dromotropic Effects

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163734 ◽  
Author(s):  
David Ojeda ◽  
Virginie Le Rolle ◽  
Hector M. Romero-Ugalde ◽  
Clément Gallet ◽  
Jean-Luc Bonnet ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Autonomic Responses ◽  
Stimulation Parameters

SPARC: Biophysical Modeling of Vagus Nerve Stimulation for Translational Scaling of Stimulation Parameters Across Species

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Eric David Musselman ◽  
Nicole A. Pelot ◽  
Jake E. Cariello ◽  
Gabriel B. Goldhagen ◽  
Warren M. Grill
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Biophysical Modeling ◽  
Stimulation Parameters
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