Novel attempts to optimize vagus nerve stimulation parameters on serotonin neuronal firing activity in the rat brain

2012 ◽  
Vol 5 (3) ◽  
pp. 422-429 ◽  
Author(s):  
Stella Manta ◽  
Mostafa El Mansari ◽  
Pierre Blier
Keyword(s):  
Vagus Nerve ◽  
Rat Brain ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Neuronal Firing ◽  
Firing Activity ◽  
Stimulation Parameters

scholarly journals Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems

2012 ◽  
Vol 16 (2) ◽  
pp. 459-470 ◽  
Author(s):  
Stella Manta ◽  
Mostafa El Mansari ◽  
Guy Debonnel ◽  
Pierre Blier
Keyword(s):  
Prefrontal Cortex ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Neuronal Firing ◽  
Adjunctive Treatment ◽  
Firing Activity ◽  
Tonic Activation ◽  
Resistant Depression

Abstract Vagus nerve stimulation (VNS) is an adjunctive treatment for resistant epilepsy and depression. Electrophysiological recordings in the rat brain have already shown that chronic VNS increases norepinephrine (NE) neuronal firing activity and, subsequently, that of serotonin (5-HT) neurons through an activation of their excitatory α1-adrenoceptors. Long-term VNS was shown to increase the tonic activation of post-synaptic 5-HT1A receptors in the hippocampus. This study was aimed at examining the effect of VNS on extracellular 5-HT, NE and dopamine (DA) levels in different brain areas using in vivo microdialysis, on NE transmission in the hippocampus, and DA neuronal firing activity using electrophysiology. Rats were implanted with a VNS device and stimulated for 14 d with standard parameters used in treatment-resistant depression (0.25 mA, 20 Hz, 500 µs, 30 s on–5 min off). The results of the present study revealed that 2-wk VNS significantly increased extracellular NE levels in the prefrontal cortex and the hippocampus and enhanced the tonic activation of post-synaptic α2-adrenoceptors on pyramidal neurons. The electrophysiological experiments revealed a significant decrease in ventral tegmental area DA neuronal firing rate after long-term VNS; extracellular DA levels were nevertheless increased in the prefrontal cortex and nucleus accumbens. Chronic VNS significantly increased extracellular 5-HT levels in the dorsal raphe but not in the hippocampus and prefrontal cortex. In conclusion, the effect of VNS in increasing the transmission of monoaminergic systems targeted in the treatment of resistant depression should be involved, at least in part, in its antidepressant properties observed in patients not responding to many antidepressant strategies.

scholarly journals Non-invasive vagus nerve stimulation reduced neuron-derived IL-1β and neuroinflammation in acute ischemic rat brain

2021 ◽  
Author(s):  
Lisa Y Yang ◽  
Kiran Bhaskar ◽  
Jeffrey Thompson ◽  
Kelsey Duval ◽  
Michel Torbey ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Rat Brain ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Non Invasive

scholarly journals Sensitivity Analysis of Vagus Nerve Stimulation Parameters on Acute Cardiac Autonomic Responses: Chronotropic, Inotropic and Dromotropic Effects

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163734 ◽  
Author(s):  
David Ojeda ◽  
Virginie Le Rolle ◽  
Hector M. Romero-Ugalde ◽  
Clément Gallet ◽  
Jean-Luc Bonnet ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Autonomic Responses ◽  
Stimulation Parameters

SPARC: Biophysical Modeling of Vagus Nerve Stimulation for Translational Scaling of Stimulation Parameters Across Species

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Eric David Musselman ◽  
Nicole A. Pelot ◽  
Jake E. Cariello ◽  
Gabriel B. Goldhagen ◽  
Warren M. Grill
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Biophysical Modeling ◽  
Stimulation Parameters
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