scholarly journals Oxidative stress and antioxidant treatment in patients with peripheral artery disease

2018 ◽  
Vol 6 (7) ◽  
pp. e13650 ◽  
Author(s):  
Panagiotis Koutakis ◽  
Ahmed Ismaeel ◽  
Patrick Farmer ◽  
Seth Purcell ◽  
Robert S. Smith ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Antioxidant Treatment ◽  
Artery Disease

Local and Systemic Inflammation and Oxidative Stress After a Single Bout of Maximal Walking in Patients With Symptomatic Peripheral Artery Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Aluisio Andrade-Lima ◽  
Natan da Silva Junior ◽  
Marcel Chehuen ◽  
Roberto Miyasato ◽  
Rodrigo W.A. Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Systemic Inflammation ◽  
Peripheral Artery ◽  
Single Bout ◽  
Artery Disease ◽  
And Oxidative Stress

scholarly journals Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

2015 ◽  
Vol 61 (5) ◽  
pp. 1249-1257 ◽  
Author(s):  
Andrew W. Gardner ◽  
Donald E. Parker ◽  
Polly S. Montgomery ◽  
Danuta Sosnowska ◽  
Ana I. Casanegra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Racial Differences ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease

2017 ◽  
Vol 595 (13) ◽  
pp. 4365-4378 ◽  
Author(s):  
Jonathan E. Harms ◽  
J. Matthew Kuczmarski ◽  
Joyce S. Kim ◽  
Gail D. Thomas ◽  
Marc P. Kaufman
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Exercise Pressor Reflex ◽  
Pressor Reflex ◽  
Artery Disease

MARKERS OF OXIDATIVE STRESS AND PERIPHERAL ARTERY DISEASE

2018 ◽  
Vol 71 (11) ◽  
pp. A2076 ◽  
Author(s):  
Jamal Hajjari ◽  
Ayman S. Tahhan ◽  
Ayman Alkhoder ◽  
Belal Kaseer ◽  
Abdelhadi Naser ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Markers Of Oxidative Stress ◽  
Artery Disease

scholarly journals Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

AGE ◽  
2016 ◽  
Vol 38 (3) ◽  
Author(s):  
Andrew W. Gardner ◽  
Polly S. Montgomery ◽  
Ana I. Casanegra ◽  
Federico Silva-Palacios ◽  
Zoltan Ungvari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Gait Characteristics ◽  
Artery Disease

scholarly journals IMPACT OF ENDOVASCULAR THERAPY ON OXIDATIVE STRESS IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

2014 ◽  
Vol 63 (12) ◽  
pp. A2142
Author(s):  
Soichiro Ebisawa ◽  
Yusuke Miyashita ◽  
Hioki Hirofumi ◽  
Masatoshi Minamisawa ◽  
Naoto Hashidume ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Endovascular Therapy ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Greater Endothelial Apoptosis and Oxidative Stress in Patients with Peripheral Artery Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Andrew W. Gardner ◽  
Donald E. Parker ◽  
Polly S. Montgomery ◽  
Danuta Sosnowska ◽  
Ana I. Casanegra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Antioxidant Capacity ◽  
Peripheral Artery Disease ◽  
Control Group ◽  
Peripheral Artery ◽  
Endothelial Apoptosis ◽  
Control Subjects ◽  
Artery Disease ◽  
And Oxidative Stress

We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 156 subjects with peripheral artery disease (PAD) and 16 healthy control subjects. Furthermore, we compared circulating inflammatory, antioxidant capacity, and vascular biomarkers between the two groups. The PAD group had a 164% higher value for endothelial cell apoptosis (P<0.001) and a 62% higher value for endothelial cellular reactive oxygen species production (P<0.001) than the control group. Furthermore, the PAD group had lower systemic antioxidant capacity measured by hydroxyl radical antioxidant capacity activity (P<0.001), higher inflammatory and vascular measures of high-sensitivity C-reactive protein (P<0.001), interleukin-8 (P<0.001), serum amyloid A (P<0.001), vascular cell adhesion molecule-1 (P<0.001), adiponectin (P<0.001), apolipoprotein B (P=0.013), apolipoprotein CIII (P=0.035), lower vascular endothelial growth factor-A (P<0.001), and hepatocyte growth factor (P<0.001) than the control group. Subjects with PAD have greater endothelial apoptosis and oxidative stress than control subjects with low burden of comorbid conditions and cardiovascular risk factors. Furthermore, subjects with PAD have lower systemic antioxidant capacity and angiogenic measures and higher circulating inflammatory parameters.

scholarly journals Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease

Antioxidants ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 145 ◽  
Author(s):  
Ahmed Ismaeel ◽  
Robert Brumberg ◽  
Jeffrey Kirk ◽  
Evlampia Papoutsi ◽  
Patrick Farmer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Arterial Stiffness ◽  
Peripheral Artery Disease ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Current Evidence ◽  
Peripheral Artery ◽  
Potential Therapeutic Role ◽  
Artery Disease ◽  
And Oxidative Stress

Peripheral artery disease (PAD) is an atherosclerotic disease characterized by a narrowing of the arteries in the lower extremities. Disease manifestations are the result of more than just reduced blood flow, and include endothelial dysfunction, arterial stiffness, and inflammation. Growing evidence suggests that these factors lead to functional impairment and decline in PAD patients. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in the pathophysiology of PAD. We also discuss the links between these factors and oxidative stress, with a focus on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2)-derived reactive oxygen species (ROS) and decreased nitric oxide (NO) bioavailability. Finally, the potential therapeutic role of NOX2 antioxidants for improving arterial function and functional status in PAD patients is explored.

Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease

2016 ◽  
Vol 38 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Aluísio H. R. A. Lima ◽  
Marilia A. Correia ◽  
Antônio H. G. Soares ◽  
Breno Q. Farah ◽  
Cláudia L. M. Forjaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Acute Effects ◽  
Peripheral Artery ◽  
Combined Exercise ◽  
Artery Disease
Sign in / Sign up

Export Citation Format

Share Document