Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease

2016 ◽  
Vol 38 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Aluísio H. R. A. Lima ◽  
Marilia A. Correia ◽  
Antônio H. G. Soares ◽  
Breno Q. Farah ◽  
Cláudia L. M. Forjaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Acute Effects ◽  
Peripheral Artery ◽  
Combined Exercise ◽  
Artery Disease

Abstract 11: Effects of Canakinumab in Patients With Peripheral Artery Disease

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Kerry S Russell ◽  
Denise Yates ◽  
Andrea Feller ◽  
Tianke Wang ◽  
Ping Chen ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Cardiovascular Events ◽  
Ankle Brachial Index ◽  
Unmet Need ◽  
Walking Distance ◽  
Plaque Progression ◽  
Peripheral Artery ◽  
Plaque Volume ◽  
Artery Disease

Background: Peripheral artery disease (PAD) affects 8.5 million people in the US. PAD patients are at high risk for cardiovascular events, and their quality of life is often significantly impaired by decreased mobility. Interleukin-1β (IL-1β) may play an important role in this disease by promoting inflammatory responses that drive atherosclerotic plaque progression and impair vascular function. We sought to test whether interruption of IL-1β signaling would improve patient mobility and decrease plaque progression in the lower extremities. Methods: 38 patients (mean age 65; 71% male) with symptomatic PAD (confirmed by ankle-brachial index) were randomized 1:1 to receive Canakinumab (150 mg subcutaneously) or placebo monthly for up to 12 months. Plaque volume in the superficial femoral artery (SFA) was assessed serially using 3.0T MRI. Mobility was assessed serially using the 6-minute walk test (maximum and pain-free walking distance). Results: Canakinumab was safe and well-tolerated. 12 patients discontinued (8 placebo, 4 Canakinumab). MRI data (from 31 patients at 3 months; 21 patients at 12 months) showed no evidence of plaque progression in the SFA at either time point in placebo-treated patients; nor was there a change in plaque volume in the Canakinumab-treated group. There was a serial and significant improvement in placebo-adjusted maximum and pain-free walking distance observed as early as 3 months after treatment with Canakinumab (58-meter improvement over placebo in pain-free distance at 3 months, P=0.01). Two placebo-treated patients required peripheral vascular interventions due to progression of disease; however, no Canakinumab-treated patients required revascularization during the study. Canakinumab decreased markers of systemic inflammation (IL-6 and hsCRP). Conclusions: Treatment with Canakinumab may improve maximum and pain-free walk distance in patients with symptomatic PAD. In conjunction with results soon to be reported for the CANTOS trial of Canakinumab for secondary prevention of cardiovascular events, additional studies may provide support that inhibition of IL-1β signaling can improve symptoms and function in this patient population with high unmet need.

scholarly journals Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease

2020 ◽  
Vol 129 (6) ◽  
pp. 1279-1289
Author(s):  
Jacob C. Monroe ◽  
Chen Lin ◽  
Susan M. Perkins ◽  
Yan Han ◽  
Brett J. Wong ◽  
...  
Keyword(s):  
Physical Function ◽  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Controlled Study ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Heat Therapy ◽  
Walking Performance ◽  
Artery Disease ◽  
Potent Vasoconstrictor

This is the first sham-controlled study to investigate the effects of leg heat therapy (HT) on walking performance, vascular function, and quality of life in patients with peripheral artery disease (PAD). Adherence to HT was high, and the treatment was well tolerated. Our findings revealed that HT applied with water-circulating trousers evokes a clinically meaningful increase in perceived physical function and reduces the serum concentration of the potent vasoconstrictor endothelin-1 in patients with PAD.

Local and Systemic Inflammation and Oxidative Stress After a Single Bout of Maximal Walking in Patients With Symptomatic Peripheral Artery Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Aluisio Andrade-Lima ◽  
Natan da Silva Junior ◽  
Marcel Chehuen ◽  
Roberto Miyasato ◽  
Rodrigo W.A. Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Systemic Inflammation ◽  
Peripheral Artery ◽  
Single Bout ◽  
Artery Disease ◽  
And Oxidative Stress

scholarly journals Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

2015 ◽  
Vol 61 (5) ◽  
pp. 1249-1257 ◽  
Author(s):  
Andrew W. Gardner ◽  
Donald E. Parker ◽  
Polly S. Montgomery ◽  
Danuta Sosnowska ◽  
Ana I. Casanegra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Racial Differences ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease

2017 ◽  
Vol 595 (13) ◽  
pp. 4365-4378 ◽  
Author(s):  
Jonathan E. Harms ◽  
J. Matthew Kuczmarski ◽  
Joyce S. Kim ◽  
Gail D. Thomas ◽  
Marc P. Kaufman
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Exercise Pressor Reflex ◽  
Pressor Reflex ◽  
Artery Disease

scholarly journals Oxidative stress and antioxidant treatment in patients with peripheral artery disease

2018 ◽  
Vol 6 (7) ◽  
pp. e13650 ◽  
Author(s):  
Panagiotis Koutakis ◽  
Ahmed Ismaeel ◽  
Patrick Farmer ◽  
Seth Purcell ◽  
Robert S. Smith ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Antioxidant Treatment ◽  
Artery Disease

MARKERS OF OXIDATIVE STRESS AND PERIPHERAL ARTERY DISEASE

2018 ◽  
Vol 71 (11) ◽  
pp. A2076 ◽  
Author(s):  
Jamal Hajjari ◽  
Ayman S. Tahhan ◽  
Ayman Alkhoder ◽  
Belal Kaseer ◽  
Abdelhadi Naser ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Markers Of Oxidative Stress ◽  
Artery Disease
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