scholarly journals Acute effects of glucagon-like peptide-1, GLP-19-36 amide , and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers

2017 ◽  
Vol 5 (4) ◽  
pp. e13102 ◽  
Author(s):  
Lasse Bremholm ◽  
Ulrik B. Andersen ◽  
Mads Hornum ◽  
Linda Hilsted ◽  
Simon Veedfald ◽  
...  
Keyword(s):  
Blood Flow ◽  
Healthy Volunteers ◽  
Acute Effects ◽  
Mesenteric Blood Flow ◽  
Cardiovascular Parameters ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Effects of meal and incretins in the regulation of splanchnic blood flow

2017 ◽  
Vol 6 (3) ◽  
pp. 179-187 ◽  
Author(s):  
Jukka Koffert ◽  
Henri Honka ◽  
Jarmo Teuho ◽  
Saila Kauhanen ◽  
Saija Hurme ◽  
...  
Keyword(s):  
Blood Flow ◽  
Glucose Disposal ◽  
Mixed Meal ◽  
Organ Specific ◽  
Randomized Intervention ◽  
Glucose Tolerant ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Randomized Intervention Study ◽  
Meal Ingestion

Objective Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. Design A non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation was performed. Methods Effects of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) infusions and mixed-meal were tested in 10 healthy, glucose tolerant subjects using PET-MRI multimodal imaging technology. Intestinal and pancreatic BF and blood volume (BV) were measured with 15O-water and 15O-carbon monoxide, respectively. Results Ingestion of a mixed-meal led to an increase in pancreatic and jejunal BF, whereas duodenal BF was unchanged. Infusion of GIP and GLP-1 reduced BF in the pancreas. However, GIP infusion doubled blood flow in the jejunum with no effect of GLP-1. Conclusion Together, our data suggest that meal ingestion leads to increases in pancreatic BF accompanied by a GIP-mediated increase in jejunal but not duodenal blood flow.

A liquid mixed meal or exogenous glucagon-like peptide 1 (GLP-1) do not alter plasma leptin concentrations in healthy volunteers

1997 ◽  
Vol 34 (3) ◽  
pp. 230-234 ◽  
Author(s):  
C. Drewes ◽  
M. A. Nauck ◽  
R. Horn ◽  
J. Holst ◽  
W. Schmiegel ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Mixed Meal ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Plasma Leptin

scholarly journals Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

2008 ◽  
Vol 55 (5) ◽  
pp. 867-874 ◽  
Author(s):  
Sanghee SEO ◽  
Sunghee JU ◽  
Hyunju CHUNG ◽  
Dahm LEE ◽  
Seungjoon PARK
Keyword(s):  
Acute Effects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Kinase Expression ◽  
Fasted Rats

Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers

Endocrine ◽  
2020 ◽  
Vol 70 (2) ◽  
pp. 292-298
Author(s):  
Bettina Winzeler ◽  
Ismael da Conceição ◽  
Julie Refardt ◽  
Clara O. Sailer ◽  
Gilles Dutilh ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Fluid Intake ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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