A liquid mixed meal or exogenous glucagon-like peptide 1 (GLP-1) do not alter plasma leptin concentrations in healthy volunteers

1997 ◽  
Vol 34 (3) ◽  
pp. 230-234 ◽  
Author(s):  
C. Drewes ◽  
M. A. Nauck ◽  
R. Horn ◽  
J. Holst ◽  
W. Schmiegel ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Mixed Meal ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Plasma Leptin

scholarly journals Effects of meal and incretins in the regulation of splanchnic blood flow

2017 ◽  
Vol 6 (3) ◽  
pp. 179-187 ◽  
Author(s):  
Jukka Koffert ◽  
Henri Honka ◽  
Jarmo Teuho ◽  
Saila Kauhanen ◽  
Saija Hurme ◽  
...  
Keyword(s):  
Blood Flow ◽  
Glucose Disposal ◽  
Mixed Meal ◽  
Organ Specific ◽  
Randomized Intervention ◽  
Glucose Tolerant ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Randomized Intervention Study ◽  
Meal Ingestion

Objective Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. Design A non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation was performed. Methods Effects of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) infusions and mixed-meal were tested in 10 healthy, glucose tolerant subjects using PET-MRI multimodal imaging technology. Intestinal and pancreatic BF and blood volume (BV) were measured with 15O-water and 15O-carbon monoxide, respectively. Results Ingestion of a mixed-meal led to an increase in pancreatic and jejunal BF, whereas duodenal BF was unchanged. Infusion of GIP and GLP-1 reduced BF in the pancreas. However, GIP infusion doubled blood flow in the jejunum with no effect of GLP-1. Conclusion Together, our data suggest that meal ingestion leads to increases in pancreatic BF accompanied by a GIP-mediated increase in jejunal but not duodenal blood flow.

Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release

2001 ◽  
Vol 281 (3) ◽  
pp. G752-G763 ◽  
Author(s):  
Feruze Y. Enç ◽  
Neşe I˙meryüz ◽  
Levent Akin ◽  
Turgut Turoğlu ◽  
Fuat Dede ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Peptide Yy ◽  
Area Under The Curve ◽  
Gut Hormones ◽  
Random Order ◽  
Mixed Meal ◽  
Carbohydrate Absorption ◽  
Plasma Response ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

We investigated the effect of acarbose, an α-glucosidase and pancreatic α-amylase inhibitor, on gastric emptying of solid meals of varying nutrient composition and plasma responses of gut hormones. Gastric emptying was determined with scintigraphy in healthy subjects, and all studies were performed with and without 100 mg of acarbose, in random order, at least 1 wk apart. Acarbose did not alter the emptying of a carbohydrate-free meal, but it delayed emptying of a mixed meal and a carbohydrate-free meal given 2 h after sucrose ingestion. In meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) while augmenting responses of CCK, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY). With mixed meal + acarbose, area under the curve (AUC) of gastric emptying was positively correlated with integrated plasma response of GLP-1 ( r = 0.68 , P < 0.02). With the carbohydrate-free meal after sucrose and acarbose ingestion, AUC of gastric emptying was negatively correlated with integrated plasma response of GIP, implying that prior alteration of carbohydrate absorption modifies gastric emptying of a meal. The results demonstrate that acarbose delays gastric emptying of solid meals and augments release of CCK, GLP-1, and PYY mainly by retarding/inhibiting carbohydrate absorption. Augmented GLP-1 release by acarbose appears to play a major role in the inhibition of gastric emptying of a mixed meal, whereas CCK and PYY may have contributory roles.

scholarly journals Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans

2008 ◽  
Vol 33 (5) ◽  
pp. 929-935 ◽  
Author(s):  
Eric M. Snyder ◽  
Richard D. Carr ◽  
Carolyn F. Deacon ◽  
Bruce D. Johnson
Keyword(s):  
Normobaric Hypoxia ◽  
Hypoxic Exposure ◽  
Healthy Humans ◽  
Endocrine Factors ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Fraction Of Inspired Oxygen ◽  
Loss Of Appetite ◽  
Plasma Leptin ◽  
Inspired Oxygen

Altitude exposure has been associated with loss of appetite and weight loss in healthy humans; however, the endocrine factors that contribute to these changes remain unclear. Leptin and glucagon-like peptide-1 (GLP-1) are peptide hormones that contribute to the regulation of appetite. Leptin increases with hypoxia; however, the influence of hypoxia on GLP-1 has not been studied in animals or humans to date. We sought to determine the influence of normobaric hypoxia on plasma leptin and GLP-1 levels in 25 healthy humans. Subjects ingested a control meal during normoxia and after 17 h of exposure to normobaric hypoxia (fraction of inspired oxygen of 12.5%, simulating approximately 4100 m). Plasma leptin was assessed before the meal, and GLP-1 was assessed premeal, at 20 min postmeal, and at 40 min postmeal. We found that hypoxia caused a significant elevation in plasma leptin levels (normoxia, 4.9 ± 0.8 pg·mL–1; hypoxia, 7.7 ± 1.5 pg·mL–1; p < 0.05; range, –16% to 190%), no change in the average GLP-1 response to hypoxia, and only a small trend toward an increase in GLP-1 levels 40 min postmeal (fasting, 15.7 ± 0.9 vs 15.9 ± 0.7 pmol·L–1; 20 min postmeal, 21.7 ± 0.9 vs 21.8 ± 1.2 pmol·L–1; 40 min postmeal, 19.5 ± 1.2 vs. 21.0 ± 1.2 pmol·L–1 for normoxia and hypoxia, respectively; p > 0.05 normoxia vs hypoxia). There was a correlation between SaO2 and leptin after the 17 h exposure (r = 0.45; p < 0.05), but no relation between SaO2 and GLP-1. These data confirm that leptin increases with hypoxic exposure in humans. Further study is needed to determine the influence of hypoxia and altitude on GLP-1 levels.

Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers

Endocrine ◽  
2020 ◽  
Vol 70 (2) ◽  
pp. 292-298
Author(s):  
Bettina Winzeler ◽  
Ismael da Conceição ◽  
Julie Refardt ◽  
Clara O. Sailer ◽  
Gilles Dutilh ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Fluid Intake ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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