scholarly journals Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding

2016 ◽  
Vol 4 (23) ◽  
pp. e13044 ◽  
Author(s):  
Amalie Ribel-Madsen ◽  
Lars I. Hellgren ◽  
Charlotte Brøns ◽  
Rasmus Ribel-Madsen ◽  
Christopher B. Newgard ◽  
...  
1975 ◽  
Vol 86 (5) ◽  
pp. 766-772 ◽  
Author(s):  
Carolyn L. Abitbol ◽  
Donita B. Feldman ◽  
Peter Ahmann ◽  
Daniel Rudman

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4315
Author(s):  
Kristyn Dunlop ◽  
Ousseynou Sarr ◽  
Nicole Stachura ◽  
Lin Zhao ◽  
Karen Nygard ◽  
...  

Low birth weight (LBW) offspring are at increased risk for developing insulin resistance, a key precursor in metabolic syndrome and type 2 diabetes mellitus. Altered skeletal muscle vasculature, extracellular matrix, amino acid and mitochondrial lipid metabolism, and insulin signaling are implicated in this pathogenesis. Using uteroplacental insufficiency (UPI) to induce intrauterine growth restriction (IUGR) and LBW in the guinea pig, we investigated the relationship between UPI-induced IUGR/LBW and later life skeletal muscle arteriole density, fibrosis, amino acid and mitochondrial lipid metabolism, markers of insulin signaling and glucose uptake, and how a postnatal high-fat, high-sugar “Western” diet (WD) modulates these changes. Muscle of 145-day-old male LBW glucose-tolerant offspring displayed diminished vessel density and altered acylcarnitine levels. Disrupted muscle insulin signaling despite maintained whole-body glucose homeostasis also occurred in both LBW and WD-fed male “lean” offspring. Additionally, postnatal WD unmasked LBW-induced impairment of mitochondrial lipid metabolism, as reflected by increased acylcarnitine accumulation. This study provides evidence that early markers of skeletal muscle metabolic dysfunction appear to be influenced by the in utero environment and interact with a high-fat/high-sugar postnatal environment to exacerbate altered mitochondrial lipid metabolism, promoting mitochondrial overload.


2011 ◽  
Vol 158 (4) ◽  
pp. 543-548.e1 ◽  
Author(s):  
Cynthia Liudmilla Blanco ◽  
Alice Kim Gong ◽  
Belinda Kay Green ◽  
Alison Falck ◽  
John Schoolfield ◽  
...  

1990 ◽  
Vol 57 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Gopal Srinivasan ◽  
Abbasian Amin ◽  
Rosita S. Pildes ◽  
Lawrence D. Lilien ◽  
Reuben Matalon

2003 ◽  
Vol 77 (3) ◽  
pp. 737-743 ◽  
Author(s):  
Brenda B Poindexter ◽  
Richard A Ehrenkranz ◽  
Barbara J Stoll ◽  
Matthew A Koch ◽  
Linda L Wright ◽  
...  

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