scholarly journals Extrapancreatic effects of incretin hormones: evidence for weight-independent changes in morphological aspects and oxidative status in insulin-sensitive organs of the obese nondiabetic Zucker rat (ZFR)

2016 ◽  
Vol 4 (15) ◽  
pp. e12886 ◽  
Author(s):  
Ides M. Colin ◽  
Henri Colin ◽  
Ines Dufour ◽  
Charles-Edouard Gielen ◽  
Marie-Christine Many ◽  
...  
Keyword(s):  
Oxidative Status ◽  
Incretin Hormones ◽  
Zucker Rat ◽  
Morphological Aspects ◽  
Extrapancreatic Effects

scholarly journals Incretin Hormones: The Link between Glycemic Index and Cardiometabolic Diseases

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1878 ◽  
Author(s):  
Teresa Salvatore ◽  
Riccardo Nevola ◽  
Pia Clara Pafundi ◽  
Lucio Monaco ◽  
Carmen Ricozzi ◽  
...  
Keyword(s):  
Glycemic Index ◽  
Extensive Literature ◽  
Incretin Hormones ◽  
Cardiometabolic Diseases ◽  
Incretin Secretion ◽  
Extrapancreatic Effects ◽  
Hormonal Milieu ◽  
The Relationship ◽  
Kinetics Of

This review aimed to describe the potential mechanisms by which incretin hormones could mediate the relationship between glycemic index and cardiometabolic diseases. A body of evidence from many studies suggests that low glycemic index (GI) diets reduces the risk for type 2 diabetes and coronary heart disease. In fact, despite the extensive literature on this topic, the mechanisms underlying unfavorable effects of high GI foods on health remain not well defined. The postprandial and hormonal milieu could play a key role in the relationship between GI and cardiovascular risk. Incretin hormones, glucagon-like peptide1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are important regulators of postprandial homeostasis by amplifying insulin secretory responses. Response of GIP and GLP-1 to GI have been studied more in depth, also by several studies on isomaltulose, which have been taken as an ideal model to investigate the kinetics of incretin secretion in response to foods’ GI. In addition, extrapancreatic effects of these incretin hormones were also recently observed. Emerging from this have been exciting effects on several targets, such as body weight regulation, lipid metabolism, white adipose tissue, cardiovascular system, kidney, and liver, which may importantly affect the health status.

Electron Microscopy of Mycoplasma Pneumoniae

1971 ◽  
Vol 29 ◽  
pp. 258-259 ◽  
Author(s):  
E. S. Boatman ◽  
G. E. Kenny
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Growth Phase ◽  
Hela Cells ◽  
Sulfonic Acid ◽  
Gamma Globulin ◽  
Horse Serum ◽  
Morphological Aspects ◽  
The Family

Information concerning the morphology and replication of organism of the family Mycoplasmataceae remains, despite over 70 years of study, highly controversial. Due to their small size observations by light microscopy have not been rewarding. Furthermore, not only are these organisms extremely pleomorphic but their morphology also changes according to growth phase. This study deals with the morphological aspects of M. pneumoniae strain 3546 in relation to growth, interaction with HeLa cells and possible mechanisms of replication.The organisms were grown aerobically at 37°C in a soy peptone yeast dialysate medium supplemented with 12% gamma-globulin free horse serum. The medium was buffered at pH 7.3 with TES [N-tris (hyroxymethyl) methyl-2-aminoethane sulfonic acid] at 10mM concentration. The inoculum, an actively growing culture, was filtered through a 0.5 μm polycarbonate “nuclepore” filter to prevent transfer of all but the smallest aggregates. Growth was assessed at specific periods by colony counts and 800 ml samples of organisms were fixed in situ with 2.5% glutaraldehyde for 3 hrs. at 4°C. Washed cells for sectioning were post-fixed in 0.8% OSO4 in veronal-acetate buffer pH 6.1 for 1 hr. at 21°C. HeLa cells were infected with a filtered inoculum of M. pneumoniae and incubated for 9 days in Leighton tubes with coverslips. The cells were then removed and processed for electron microscopy.

Characterization of hepatobiliary organic anion transporter regulation in the Zucker rat

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
A Geier ◽  
CG Dietrich ◽  
C Gartung ◽  
F Lammert ◽  
HE Wasmuth ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Zucker Rat ◽  
Anion Transporter

Incretin hormones in pathogenesis of secondary hyperglycaemia in patients with Cushing's disease and acromegaly

2018 ◽  
Author(s):  
Lubov Machekhina ◽  
Ekaterina Shestakova ◽  
Lyudmila Astafieva ◽  
Marina Shestakova
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Incretin Hormones

LIK066, a Dual SGLT1/2 Inhibitor, Reduces Weight and Improves Multiple Incretin Hormones in Clinical Proof-of-Concept Studies in Obese Patients With or Without Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 114-LB ◽  
Author(s):  
YANLING HE ◽  
WILLIAM G. HAYNES ◽  
CHARLES D. MEYERS ◽  
AHMED AMER ◽  
YIMING ZHANG ◽  
...  
Keyword(s):  
Incretin Hormones ◽  
Obese Patients ◽  
Proof Of Concept

78-OR: Glycaemia, Beta-Cell Function, and Incretin Hormones Post-OGTT One Year after Gastric Bypass and Sleeve Gastrectomy in Patients with Morbid Obesity and Type 2 Diabetes: An RCT (Oseberg Study)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 78-OR
Author(s):  
FARHAT FATIMA ◽  
JØRAN HJELMESÆTH ◽  
KARE I. BIRKELAND ◽  
HANNE L. GULSETH ◽  
JENS K. HERTEL ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Morbid Obesity ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Incretin Hormones ◽  
One Year

Different oxidative status and expression of calcium channel components in stress-induced dysfunctional chicken muscle

2017 ◽  
Vol 95 (4) ◽  
pp. 1565
Author(s):  
T. Xing ◽  
X. Zhao ◽  
P. Wang ◽  
H. Chen ◽  
X. Xu ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Oxidative Status ◽  
Chicken Muscle
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