LIK066, a Dual SGLT1/2 Inhibitor, Reduces Weight and Improves Multiple Incretin Hormones in Clinical Proof-of-Concept Studies in Obese Patients With or Without Diabetes

YANLING HE; WILLIAM G. HAYNES; CHARLES D. MEYERS; AHMED AMER; YIMING ZHANG; PING C. MAHLING; ANISHA E. MENDONZA; SHENGLIN MA; WILLIAM CHUTKOW; ERIC S. BACHMAN

doi:10.2337/db18-114-lb

LIK066, a Dual SGLT1/2 Inhibitor, Reduces Weight and Improves Multiple Incretin Hormones in Clinical Proof-of-Concept Studies in Obese Patients With or Without Diabetes

Diabetes ◽

10.2337/db18-114-lb ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 114-LB ◽

Cited By ~ 1

Author(s):

YANLING HE ◽

WILLIAM G. HAYNES ◽

CHARLES D. MEYERS ◽

AHMED AMER ◽

YIMING ZHANG ◽

...

Keyword(s):

Incretin Hormones ◽

Obese Patients ◽

Proof Of Concept

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A prospective cohort study of laparoscopic sleeve gastrectomy for weight loss in obese patients on haemodialysis: proof of concept

http://isrctn.org/> ◽

10.1186/isrctn24299618 ◽

2013 ◽

Author(s):

Helen MacLaughlin

Keyword(s):

Weight Loss ◽

Cohort Study ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Obese Patients ◽

Proof Of Concept

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First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity

Endoscopy International Open ◽

10.1055/a-1127-2991 ◽

2020 ◽

Vol 08 (05) ◽

pp. E607-E610 ◽

Cited By ~ 1

Author(s):

Hung Leng Kaan ◽

Phuoc Thien Phan ◽

Anthony Meng Huat Tiong ◽

Muneaki Miyasaka ◽

Soo Jay Phee ◽

...

Keyword(s):

Feasibility Study ◽

Animal Studies ◽

Obese Patients ◽

Proof Of Concept ◽

External Magnet ◽

Inflated Balloon ◽

Term Efficacy ◽

Treatment Of Obesity ◽

Established Treatment

AbstractIntragastric balloons (IGBs) are an established treatment option for obesity. Major barriers to dissemination of IGBs include lack of long-term efficacy outcomes, safety concerns, cost, and tolerability. We developed a novel ingestible magnetically inflated balloon capsule (IMI-BC) in hopes of overcoming these challenges. The IMI-BC is significantly cheaper than IGBs currently available on the market. We performed proof-of-concept animal studies and a first-in-human feasibility study to demonstrate the feasibility of inflating the IMI-BC using an external magnet. Further studies are currently being conducted to evaluate the safety, tolerability, and long-term efficacy of the IMI-BC. When fully developed, we anticipate that this device will benefit obese patients.

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Direct measurement of electron-diffraction-pattern intensities using an energy loss spectrometer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100155311 ◽

1989 ◽

Vol 47 ◽

pp. 668-669

Author(s):

A. G. Jackson ◽

M. Rowe

Keyword(s):

Thermal Effects ◽

Dynamic Range ◽

Scattering Amplitude ◽

Dynamical Theory ◽

Site Symmetry ◽

Proof Of Concept ◽

Parallel Acquisition ◽

Kinematic Approximation ◽

Speed Up ◽

Structure Calculations

Diffraction intensities from intermetallic compounds are, in the kinematic approximation, proportional to the scattering amplitude from the element doing the scattering. More detailed calculations have shown that site symmetry and occupation by various atom species also affects the intensity in a diffracted beam. [1] Hence, by measuring the intensities of beams, or their ratios, the occupancy can be estimated. Measurement of the intensity values also allows structure calculations to be made to determine the spatial distribution of the potentials doing the scattering. Thermal effects are also present as a background contribution. Inelastic effects such as loss or absorption/excitation complicate the intensity behavior, and dynamical theory is required to estimate the intensity value.The dynamic range of currents in diffracted beams can be 104or 105:1. Hence, detection of such information requires a means for collecting the intensity over a signal-to-noise range beyond that obtainable with a single film plate, which has a S/N of about 103:1. Although such a collection system is not available currently, a simple system consisting of instrumentation on an existing STEM can be used as a proof of concept which has a S/N of about 255:1, limited by the 8 bit pixel attributes used in the electronics. Use of 24 bit pixel attributes would easily allowthe desired noise range to be attained in the processing instrumentation. The S/N of the scintillator used by the photoelectron sensor is about 106 to 1, well beyond the S/N goal. The trade-off that must be made is the time for acquiring the signal, since the pattern can be obtained in seconds using film plates, compared to 10 to 20 minutes for a pattern to be acquired using the digital scan. Parallel acquisition would, of course, speed up this process immensely.

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