scholarly journals Lower limb conduit artery endothelial responses to acute upper limb exercise in spinal cord injured and able-bodied men

2015 ◽  
Vol 3 (4) ◽  
pp. e12367 ◽  
Author(s):  
Julia O. Totosy de Zepetnek ◽  
Jason S. Au ◽  
David S. Ditor ◽  
Maureen J. MacDonald
Spinal Cord ◽  
2012 ◽  
Vol 50 (11) ◽  
pp. 822-826 ◽  
Author(s):  
A Zafeiridis ◽  
A V Vasiliadis ◽  
A Doumas ◽  
N Galanis ◽  
T Christoforidis ◽  
...  

2015 ◽  
Vol 100 (10) ◽  
pp. 1107-1117 ◽  
Author(s):  
J. O. Totosy de Zepetnek ◽  
D. S. Ditor ◽  
J. S. Au ◽  
M. J. MacDonald

2017 ◽  
Vol 313 (5) ◽  
pp. H861-H870 ◽  
Author(s):  
Kathryn M. DeVeau ◽  
Kathryn A. Harman ◽  
Jordan W. Squair ◽  
Andrei V. Krassioukov ◽  
David S. K. Magnuson ◽  
...  

Active upper-limb and passive lower-limb exercise are two interventions used in the spinal cord injury (SCI) population. Although the global cardiac responses have been previously studied, it is unclear how either exercise influences contractile cardiac function. Here, the cardiac contractile and volumetric responses to upper-limb (swim) and passive lower-limb exercise were investigated in rodents with a severe high-thoracic SCI. Animals were divided into control (CON), SCI no exercise (NO-EX), SCI passive hindlimb cycling (PHLC), or SCI swim (SWIM) groups. Severe contusion SCI was administered at the T2 level. PHLC and SWIM interventions began on day 8 postinjury and lasted 25 days. Echocardiography and dobutamine stress echocardiography were performed before and after injury. Cardiac contractile indexes were assessed in vivo at study termination via a left ventricular pressure-volume conductance catheter. Stroke volume was reduced after SCI (91 µl in the NO-EX group vs. 188 µl in the CON group, P < 0.05) and was reversed at study termination in the PHLC (167 µl) but not SWIM (90 µl) group. Rates of contraction were reduced in NO-EX versus CON groups (6,079 vs. 9,225 mmHg, respectively, P < 0.05) and were unchanged by PHLC and SWIM training. Similarly, end-systolic elastance was reduced in the NO-EX versus CON groups (0.67 vs. 1.37 mmHg/µl, respectively, P < 0.05) and was unchanged by PHLC or SWIM training. Dobutamine infusion normalized all pressure indexes in each SCI group (all P < 0.05). In conclusion, PHLC improves flow-derived cardiac indexes, whereas SWIM training displayed no cardiobeneficial effect. Pressure-derived deficits were corrected only with dobutamine, suggesting that reduced β-adrenergic stimulation is principally responsible for the impaired cardiac contractile function after SCI. NEW & NOTEWORTHY This is the first direct comparison between the cardiac changes elicited by active upper-limb or passive lower-limb exercise after spinal cord injury. Here, we demonstrate that lower-limb exercise positively influences flow-derived cardiac indexes, whereas upper-limb exercise does not. Furthermore, neither intervention corrects the cardiac contractile dysfunction associated with spinal cord injury.


2021 ◽  
Vol 9 (4) ◽  
pp. 3883-3887
Author(s):  
Swati V. Kubal ◽  
◽  
Kshitija S. Ghole ◽  

Introduction: Osteoarthritis of knee is a progressive joint disease which produces pain, inflammation and destruction of joint which in turn leads to range of motion limitation and walking disabilities. Affection in physical functioning is determined not only by just activities involving lower limb capacity but also by the activities which require use of upper extremities. Hence in this study, 6MWD and no. of rings moved in 6 minutes were taken as an outcome measures for determining the exercise capacity. KOOS is a self-administered questionnaire which was used in its cross culturally adapted format for determining the functional disability in patients. Objectives: 1. To study correlation of exercise capacity with functional disability in patients with osteoarthritis of knee. 2. To study correlation of upper limb exercise capacity with lower limb exercise capacity in patients with osteoarthritis of knee. Methods: Cross sectional, observational study including 30 patients of either gender having unilateral osteoarthritis of knee conducted in a tertiary care hospital. Results: No. of rings moved in 6 minutes and global KOOS score showed no statistically significant correlation. 6MWD and global KOOS score showed no statistically significant correlation. 6 minute walk distance and 6 minute peg board ring test showed no statistically significant correlation. Conclusion: The study suggests that there is no correlation of exercise capacity with functional disability in patients with osteoarthritis of knee. Also, there is no correlation found between upper limb exercise capacity and lower limb exercise capacity in patients with osteoarthritis of knee. KEY WORDS: Knee osteoarthritis, Knee pain, squat depth, functional disability, cardiorespiratory endurance, Knee Injury and Osteoarthritis Outcome Score, Quality of life.


Spinal Cord ◽  
1989 ◽  
Vol 27 (2) ◽  
pp. 133-139 ◽  
Author(s):  
R R Ingram ◽  
R K Suman ◽  
P A Freeman

CHEST Journal ◽  
1990 ◽  
Vol 97 (5) ◽  
pp. 1077-1082 ◽  
Author(s):  
Fiona R. Lake ◽  
Kathryn Henderson ◽  
Tom Briffa ◽  
Janet Openshaw ◽  
A. William Musk

1995 ◽  
Vol 44 (4) ◽  
pp. 447-455 ◽  
Author(s):  
KOJIRO ISHII ◽  
MASAHIRO YAMASAKI ◽  
SATOSHI MURAKI ◽  
TAKASHI KOMURA ◽  
KUNIO KIKUCHI ◽  
...  

Author(s):  
Makamas Kumprou ◽  
Pipatana Amatachaya ◽  
Thanat Sooknuan ◽  
Preeda Arayawichanon ◽  
Thiwabhorn Thaweewannakij ◽  
...  

Background: Walking devices are frequently prescribed for many individuals, including those with spinal cord injury (SCI), to promote their independence. However, without proper screening and follow-up care, the individuals may continue using the same device when their conditions have progressed, that may possibly worsen their walking ability. Objective: This study developed an upper limb loading device (ULLD), and assessed the possibility of using the tool to determine the optimal walking ability of ambulatory participants with SCI who used a walking device daily ([Formula: see text]). Methods: All participants were assessed for their optimal walking ability, i.e., the ability of walking with the least support device or no device as they could do safely and confidently. The participants were also assessed for their amount of weight-bearing on the upper limbs or upper limb loading while walking, amount of weight-bearing on the lower limbs or lower limb loading while stepping of the other leg, and walking performance. Results: The findings indicated that approximately one third of the participants (31%) could progress their walking ability from their current ability, whereby four participants could even walk without a walking device. The amount of upper limb loading while walking, lower limb loading ability, and walking performance were significantly different among the groups of optimal walking ability ([Formula: see text]). Furthermore, the amount of upper limb loading showed negative correlation to the amount of lower limb loading and walking performance ([Formula: see text] to [Formula: see text]0.493, [Formula: see text]). Conclusion: The findings suggest the potential benefit of using the upper limb loading device and the amount of upper limb loading for walking device prescription, and monitoring the change of walking ability among ambulatory individuals with SCI.


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