Human telomere RNA structure and function

2018 ◽  
Vol 4 ◽  
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
Human Telomere ◽  
And Function

Applications of synthetic oligoribonucleotide analogues in studies of RNA structure and function

1994 ◽  
Vol 106 (5) ◽  
pp. 1003-1022
Author(s):  
Jane A. Grasby ◽  
Clare E. Pritchard ◽  
Michael J. Gait
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
And Function

Insights into RNA structure and function from genome-wide studies

2014 ◽  
Vol 15 (7) ◽  
pp. 469-479 ◽  
Author(s):  
Stefanie A. Mortimer ◽  
Mary Anne Kidwell ◽  
Jennifer A. Doudna
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
Genome Wide ◽  
And Function

scholarly journals Computational design of three-dimensional RNA structure and function

2019 ◽  
Vol 14 (9) ◽  
pp. 866-873 ◽  
Author(s):  
Joseph D. Yesselman ◽  
Daniel Eiler ◽  
Erik D. Carlson ◽  
Michael R. Gotrik ◽  
Anne E. d’Aquino ◽  
...  
Keyword(s):  
Rna Structure ◽  
Three Dimensional ◽  
Computational Design ◽  
Structure And Function ◽  
And Function

scholarly journals Evidence for Hidden Involvement of N3-Protonated Guanine in RNA Structure and Function

ACS Omega ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 699-709 ◽  
Author(s):  
Antarip Halder ◽  
Saurabh Vemuri ◽  
Rohit Roy ◽  
Jayanth Katuri ◽  
Dhananjay Bhattacharyya ◽  
...  
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
And Function

scholarly journals Recent developments in reversible photoregulation of oligonucleotide structure and function

2017 ◽  
Vol 46 (4) ◽  
pp. 1052-1079 ◽  
Author(s):  
Anouk S. Lubbe ◽  
Wiktor Szymanski ◽  
Ben L. Feringa
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
Dna And Rna ◽  
Recent Developments ◽  
And Function ◽  
Critical Overview

A critical overview is given of recent applications of molecular photoswitches to modulate DNA and RNA structure and function.

Graph Applications to RNA Structure and Function

2012 ◽  
pp. 23-51 ◽  
Author(s):  
Namhee Kim ◽  
Katherine Niccole Fuhr ◽  
Tamar Schlick
Keyword(s):  
Rna Structure ◽  
Structure And Function ◽  
And Function

scholarly journals Changed reactivity of secondary hydroxyl groups in C8-modified adenosine – lessons learned from silylation

2020 ◽  
Author(s):  
Jennifer Frommer ◽  
Sabine Müller
Keyword(s):  
Building Block ◽  
Rna Structure ◽  
Building Blocks ◽  
Structure And Function ◽  
Lessons Learned ◽  
Hydroxyl Groups ◽  
Modified Oligonucleotides ◽  
Secondary Hydroxyl ◽  
Protection Scheme ◽  
And Function

Synthesis of site-specifically modified oligonucleotides has become a major tool for RNA structure and function studies. Reporter groups or specific functional entities are required to be attached at a pre-defined site of the oligomer.  An attractive strategy is the incorporation of suitably functionalized building blocks that allow post-synthetic conjugation of the desired moiety. A C8-alkynyl modified adenosine derivative was synthesized, reviving an old synthetic pathway for iodination of purine nucleobases. Silylation of the C8-alkynyl modified adenosine revealed unexpected selectivity of the two secondary sugar hydroxyl groups, with the 3'-O-isomer being preferentially formed. Optimization of the protection scheme lead to a new and economic route to the desired C8-alkynylated building block and its incorporation in RNA.

Sign in / Sign up

Export Citation Format

Share Document