The role and epigenetic regulation of the CDX gene family in human cancer

2015 ◽  
Keyword(s):  
Gene Family ◽  
Epigenetic Regulation ◽  
Human Cancer

scholarly journals Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuanjun Lu ◽  
Yau-Tuen Chan ◽  
Hor-Yue Tan ◽  
Sha Li ◽  
Ning Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Epigenetic Regulation ◽  
Potential Role ◽  
Human Cancer

scholarly journals Epigenetic Regulation of m6A Modifications in Human Cancer

2020 ◽  
Vol 19 ◽  
pp. 405-412 ◽  
Author(s):  
Wei Zhao ◽  
Xiaoqian Qi ◽  
Lina Liu ◽  
Shiqing Ma ◽  
Jingwen Liu ◽  
...  
Keyword(s):  
Epigenetic Regulation ◽  
Human Cancer

scholarly journals Genetic and Epigenetic Regulation of the FLO Gene Family Generates Cell-Surface Variation in Yeast

Cell ◽  
2004 ◽  
Vol 116 (3) ◽  
pp. 405-415 ◽  
Author(s):  
Adrian Halme ◽  
Stacie Bumgarner ◽  
Cora Styles ◽  
Gerald R Fink
Keyword(s):  
Cell Surface ◽  
Gene Family ◽  
Epigenetic Regulation ◽  
Surface Variation

scholarly journals Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia

Haematologica ◽  
2007 ◽  
Vol 92 (2) ◽  
pp. 153-162 ◽  
Author(s):  
J. Roman-Gomez ◽  
A. Jimenez-Velasco ◽  
X. Agirre ◽  
J. A. Castillejo ◽  
G. Navarro ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Epigenetic Regulation ◽  
Myeloid Leukemia ◽  
Human Cancer ◽  
Cancer Testis Antigen ◽  
Antigen Gene ◽  
Cancer Testis

scholarly journals Epigenetic regulation of telomeres in human cancer

Oncogene ◽  
2008 ◽  
Vol 27 (54) ◽  
pp. 6817-6833 ◽  
Author(s):  
E Vera ◽  
A Canela ◽  
M F Fraga ◽  
M Esteller ◽  
M A Blasco
Keyword(s):  
Epigenetic Regulation ◽  
Human Cancer

scholarly journals The whale shark genome reveals patterns of vertebrate gene family evolution

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Milton Tan ◽  
Anthony K Redmond ◽  
Helen Dooley ◽  
Ryo Nozu ◽  
Keiichi Sato ◽  
...  
Keyword(s):  
Gene Family ◽  
Human Cancer ◽  
Gene Families ◽  
Immune Defense ◽  
Gene Family Evolution ◽  
Whale Shark ◽  
Ancestral Gene ◽  
Long Read ◽  
Pathogen Recognition Receptors ◽  
Major Increase

Chondrichthyes (cartilaginous fishes) are fundamental for understanding vertebrate evolution, yet their genomes are understudied. We report long-read sequencing of the whale shark genome to generate the best gapless chondrichthyan genome assembly yet with higher contig contiguity than all other cartilaginous fish genomes, and studied vertebrate genomic evolution of ancestral gene families, immunity, and gigantism. We found a major increase in gene families at the origin of gnathostomes (jawed vertebrates) independent of their genome duplication. We studied vertebrate pathogen recognition receptors (PRRs), which are key in initiating innate immune defense, and found diverse patterns of gene family evolution, demonstrating that adaptive immunity in gnathostomes did not fully displace germline-encoded PRR innovation. We also discovered a new Toll-like receptor (TLR29) and three NOD1 copies in the whale shark. We found chondrichthyan and giant vertebrate genomes had decreased substitution rates compared to other vertebrates, but gene family expansion rates varied among vertebrate giants, suggesting substitution and expansion rates of gene families are decoupled in vertebrate genomes. Finally, we found gene families that shifted in expansion rate in vertebrate giants were enriched for human cancer-related genes, consistent with gigantism requiring adaptations to suppress cancer.

scholarly journals The FAT epidemic: A gene family frequently mutated across multiple human cancer types

Cell Cycle ◽  
2013 ◽  
Vol 12 (7) ◽  
pp. 1011-1012 ◽  
Author(s):  
Luc G.T. Morris ◽  
Deepa Ramaswami ◽  
Timothy A. Chan
Keyword(s):  
Gene Family ◽  
Human Cancer ◽  
Cancer Types
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