scholarly journals Epigenetic regulation of telomeres in human cancer

Oncogene ◽  
2008 ◽  
Vol 27 (54) ◽  
pp. 6817-6833 ◽  
Author(s):  
E Vera ◽  
A Canela ◽  
M F Fraga ◽  
M Esteller ◽  
M A Blasco
Keyword(s):  
Epigenetic Regulation ◽  
Human Cancer

scholarly journals Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuanjun Lu ◽  
Yau-Tuen Chan ◽  
Hor-Yue Tan ◽  
Sha Li ◽  
Ning Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Epigenetic Regulation ◽  
Potential Role ◽  
Human Cancer

scholarly journals Epigenetic Regulation of m6A Modifications in Human Cancer

2020 ◽  
Vol 19 ◽  
pp. 405-412 ◽  
Author(s):  
Wei Zhao ◽  
Xiaoqian Qi ◽  
Lina Liu ◽  
Shiqing Ma ◽  
Jingwen Liu ◽  
...  
Keyword(s):  
Epigenetic Regulation ◽  
Human Cancer

scholarly journals Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia

Haematologica ◽  
2007 ◽  
Vol 92 (2) ◽  
pp. 153-162 ◽  
Author(s):  
J. Roman-Gomez ◽  
A. Jimenez-Velasco ◽  
X. Agirre ◽  
J. A. Castillejo ◽  
G. Navarro ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Epigenetic Regulation ◽  
Myeloid Leukemia ◽  
Human Cancer ◽  
Cancer Testis Antigen ◽  
Antigen Gene ◽  
Cancer Testis

scholarly journals Emerging Epigenetic Regulation of Circular RNAs in Human Cancer

2019 ◽  
Vol 16 ◽  
pp. 589-596 ◽  
Author(s):  
Jie Wu ◽  
Xiaoqian Qi ◽  
Lina Liu ◽  
Xin Hu ◽  
Jingwen Liu ◽  
...  
Keyword(s):  
Epigenetic Regulation ◽  
Human Cancer ◽  
Circular Rnas

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Human Cancer ◽  
Glucose Production ◽  
Liver Mitochondria ◽  
New Drugs ◽  
Structural Isomer ◽  
Rat Liver Mitochondria ◽  
Ionization Mass ◽  
Ampk Activation ◽  
Starting Point

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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