scholarly journals Evaluation of the Relationship between Antioxidant Gene Polymorphisms (Endothelial Nitric Oxide Synthase, Myeloperoxidase, Uncoupling Protein 2) and Breast Cancer

2020 ◽  
Author(s):  
Dilek Erdem
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Antioxidant Gene ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
The Relationship

scholarly journals Analysis of Human Bradykinin Receptor Gene and Endothelial Nitric Oxide Synthase Gene Polymorphisms in End-Stage Renal Disease Among Malaysians

2014 ◽  
Vol 17 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Vasudevan R. ◽  
Ismail P. ◽  
Jaafar N.I. ◽  
Mohamad N.A. ◽  
Etemad E. ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
End Stage Renal Disease ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Enos Gene ◽  
Stage Renal Disease ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Abstract The aim of this study was to determine the association of the c.894G>T; p.Glu298Asp polymorphism and the variable number tandem repeat (VNTR) polymorphism of the endothelial nitric oxide synthase (eNOS) gene and c.181C>T polymorphism of the bradykinin type 2 receptor gene (B2R) in Malaysian end-stage renal disease (ESRD) subjects. A total of 150 ESRD patients were recruited from the National Kidney Foundation’s (NKF)dialysis centers in Malaysia and compared with 150 normal healthy individuals. Genomic DNA was extracted from buccal cells of all the subjects. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was carried out to amplify the products and the restricted fragments were separated by agarose gel electrophoresis. Statistical analyses were carried out using software where a level of p <0.05 was considered to be statistically significant. The genotypic and allelic frequencies of the B2R gene (c.181C>T, 4b/a) and eNOS gene (c.894G>T) polymorphisms were not statistically significant (p >0.05) when compared to the control subjects. The B2R and eNOS gene polymorphisms may not be considered as genetic susceptibility markers for Malaysian ESRD subjects.

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