Mechanism of ocular barriers modulation by low-intensity low-frequency ultrasound on sclera and retinal pigment epithelium

2016 ◽  
Author(s):  
Langston Wai Leung Suen
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Low Frequency ◽  
Low Intensity ◽  
Low Frequency Ultrasound ◽  
Frequency Ultrasound

scholarly journals Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound

PLoS ONE ◽  
2008 ◽  
Vol 3 (10) ◽  
pp. e3511 ◽  
Author(s):  
William J. Tyler ◽  
Yusuf Tufail ◽  
Michael Finsterwald ◽  
Monica L. Tauchmann ◽  
Emily J. Olson ◽  
...  
Keyword(s):  
Low Frequency ◽  
Neuronal Circuits ◽  
Low Intensity ◽  
Low Frequency Ultrasound ◽  
Frequency Ultrasound

scholarly journals Ultrassom terapêutico para cicatrização de feridas: revisão sistemática

2017 ◽  
Vol 15 (3) ◽  
pp. 518-529
Author(s):  
Raciele Ivandra Guarda Korelo ◽  
Luiz Claudio Fernandes
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
High Frequency Ultrasound ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Low Frequency Ultrasound ◽  
Frequency Ultrasound

Introdução: o uso do ultrassom terapêutico (UST) para cicatrização de feridas ainda é discutido pela comunidade científica. Objetivo: determinar se o UST produz desfechos benéficos na cicatrização de feridas e quais tem sido os parâmetros utilizados para proporcionar melhor dose-resposta. Métodos: Foram pesquisadas as bases de dados PubMEd, SciELO e PEDro. Foram selecionados 19 ensaios clínicos, avaliados pelas escalas PEDro e JADAD. Resultados: dos 19 estudos, 8 relacionaram-se à aplicação do NCLFU (Noncontact Low Frequency Ultrasound) com evidência moderada para sua aplicação, 6 à aplicação do HFU (High Frequency Ultrasound) e 1 à aplicação de LIPUS (Low Intensity Pulsed Ultrasound), ambos com baixa evidência. Quanto a relação dose-resposta, não há concordância entre os estudos desta revisão. Conclusões: existe evidência moderada da NCLFU e limitada da HFU como recurso adjuvante para o tratamento de feridas, não sendo possível responder com clareza a melhor relação dose-resposta.

scholarly journals Efficacy Estimation of Microbubble-Assisted Local Sonothrombolysis Using a Catheter with a Series of Miniature Transducers

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 612
Author(s):  
Peiyang Li ◽  
Wenchang Huang ◽  
Jie Xu ◽  
Weiwei Shao ◽  
Yaoyao Cui
Keyword(s):  
Intravascular Ultrasound ◽  
High Frequency ◽  
Low Frequency ◽  
Clinical Applications ◽  
Clot Lysis ◽  
Low Intensity ◽  
Low Frequency Ultrasound ◽  
Low Intensity Ultrasound ◽  
Ultrasound Energy ◽  
Frequency Ultrasound

Intravascular ultrasound has good prospects for clinical applications in sonothrombolysis. The catheter-based side-looking intravascular ultrasound thrombolysis (e.g., Ekosonic catheters) used in clinical studies has a high frequency (2 MHz). The lower-frequency ultrasound requires a larger-diameter transducer. In our study, we designed and manufactured a small ultrasound-based prototype catheter that can emit a lower frequency ultrasound (1.1 MHz). In order to evaluate the safety and efficacy of local low-frequency ultrasound-enhanced thrombolysis, a microbubble (MB) was introduced to augment thrombolysis effect of locally delivered low-intensity ultrasound. The results demonstrated that combination of ultrasound and MB realized higher clot lysis than urokinase-only treatment (17.0% ± 1.2% vs. 14.9% ± 2.7%) under optimal ultrasound settings of 1.1 MHz, 0.414 MPa, 4.89 W/cm2, 5% duty cycle and MB concentration of 60 μg/mL. When urokinase was added, the fibrinolysis accelerated by MB and ultrasound resulted in a further increased thrombolysis rate that was more than two times than that of urokinase alone (36.7% ± 5.5% vs. 14.9% ± 2.7%). However, a great quantity of ultrasound energy was required to achieve substantial clot lysis without MB, leading to the situation that temperature accumulated inside the clot became harmful. We suggest that MB-assisted local sonothrombolysis be considered as adjuvant therapy of thrombolytic agents.

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