scholarly journals Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment

ALTEX ◽  
2011 ◽  
Vol 28 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Gavin Maxwell
Keyword(s):  
Risk Assessment ◽  
Test Methods ◽  
Animal Test ◽  
Skin Sensitisation

scholarly journals Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

2015 ◽  
Vol 29 (1) ◽  
pp. 259-270 ◽  
Author(s):  
Kerstin Reisinger ◽  
Sebastian Hoffmann ◽  
Nathalie Alépée ◽  
Takao Ashikaga ◽  
Joao Barroso ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Test Methods ◽  
Systematic Evaluation ◽  
Animal Test ◽  
Skin Sensitisation

Relevance of Animal Studies in Regulatory Toxicology: Current Approaches and Future Opportunities

1996 ◽  
Vol 24 (2) ◽  
pp. 173-178
Author(s):  
Johannes J.M. van de Sandt ◽  
Victor J. Feron
Keyword(s):  
Risk Assessment ◽  
Risk Evaluation ◽  
Animal Studies ◽  
Regulatory Toxicology ◽  
Animal Test ◽  
Toxicity Studies ◽  
Increasing Knowledge ◽  
Scientific Value

With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach, in order to increase the relevance of each animal test conducted. The development of new types of toxicity studies and their application in risk evaluation are also described.

scholarly journals Safety Evaluation of Absorbent Hygiene Pads: A Review on Assessment Framework and Test Methods

2018 ◽  
Vol 10 (11) ◽  
pp. 4146 ◽  
Author(s):  
Jihyun Bae ◽  
Hoonjeong Kwon ◽  
Jooyoun Kim
Keyword(s):  
Risk Assessment ◽  
Safety Evaluation ◽  
Chemical Exposure ◽  
Test Methods ◽  
Hazard Identification ◽  
Superior Performance ◽  
Assessment Framework ◽  
Potential Health ◽  
Hazard Characterization ◽  
Post Market

Disposable absorbent hygiene products have evolved for superior performance, enhancing the convenience of daily lives. However, the use of disposable hygiene pads has brought safety concerns on chemical exposure, and significant efforts have been made to assess the potential risks associated with use of hygiene pads. This article intends to overview the safety assessment framework of diapers and feminine pads, which includes hazard identification, hazard characterization, exposure assessment, risk characterization, and post-market risk management. Risk assessment of various constituents are reviewed for quantification methods and conservative estimation of exposure parameters. By reviewing the up-to-date considerations in risk assessment, we aim to provide insightful discussion on safety evaluation of current versions of disposable absorbent products. More clinical testing and post-market surveillance are needed for continuous monitoring of potential health impacts of advanced products and constituents.

Correlation of Animal Test Methods with Human Experience for Household Products

1984 ◽  
Vol 3 (1) ◽  
pp. 53-64 ◽  
Author(s):  
F. E. Freeberg ◽  
J. F. Griffith ◽  
R. D. Bruce ◽  
P. H. S. Bay
Keyword(s):  
Human Experience ◽  
Test Methods ◽  
Animal Test ◽  
Household Products

scholarly journals Assessing skin sensitization hazard in mice and men using non-animal test methods

2015 ◽  
Vol 71 (2) ◽  
pp. 337-351 ◽  
Author(s):  
Daniel Urbisch ◽  
Annette Mehling ◽  
Katharina Guth ◽  
Tzutzuy Ramirez ◽  
Naveed Honarvar ◽  
...  
Keyword(s):  
Test Methods ◽  
Skin Sensitization ◽  
Animal Test

scholarly journals A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products

2021 ◽  
pp. 105075
Author(s):  
G. Reynolds ◽  
J. Reynolds ◽  
N. Gilmour ◽  
R. Cubberley ◽  
S. Spriggs ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cosmetic Products ◽  
Next Generation ◽  
Skin Sensitisation

Ocular Safety: A Silent (In Vitro) Success Story

2002 ◽  
Vol 30 (2_suppl) ◽  
pp. 69-74 ◽  
Author(s):  
Rodger D. Curren ◽  
John W. Harbell
Keyword(s):  
Raw Materials ◽  
Test Methods ◽  
In Vitro Tests ◽  
High Dose ◽  
Animal Testing ◽  
Animal Test ◽  
Ocular Irritation ◽  
Irritation Test ◽  
Dose Levels

Ocular irritation testing has been one of the animal test methods most criticised by animal welfare advocates. Additional criticism has arisen from within the scientific community, based on the variability of the animal test results and the questionable relevance of the extremely high dose levels employed. As a result, the Draize eye irritation test has been one of the main targets for in vitro replacement. Despite extensive efforts, however, there is still no in vitro method that is fully validated as a regulatory replacement. In spite of this, many individual companies are using diverse in vitro ocular irritation tests to gain important safety and efficacy information about their products and raw materials, eliminating the need for animal testing in the process. This is done in a safe fashion by applying intelligent testing paradigms. ECVAM has played a major role in this success, through its many programmes that have emphasised the importance of understanding the true toxicological need, and then using in vitro tests to provide that information. Thus, even in the absence of a successfully validated regulatory assay, the desired result of reducing animal testing is being met.

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