scholarly journals Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

ALTEX ◽  
2018 ◽  
pp. 51-64 ◽  
Author(s):  
Weihsueh Chiu
Keyword(s):  
High Throughput ◽  
In Vitro Toxicity ◽  
Toxicity Screening ◽  
Iarc Monograph ◽  
Working Groups

In vitro toxicity screening tests: A comparison of activation systems and treatment protocols among different laboratories

1983 ◽  
Vol 8 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Sabine H. H. Swierenga ◽  
David E. Amacher ◽  
Robert T. Christian ◽  
Joanne T. Emerman ◽  
Linda B. Jacobsen ◽  
...  
Keyword(s):  
Screening Tests ◽  
In Vitro Toxicity ◽  
Toxicity Screening ◽  
Treatment Protocols

Some experimental aspects of an in vitro toxicity screening in developing new pharmaceuticals

2017 ◽  
Vol 280 ◽  
pp. S267
Author(s):  
Alla Voronina ◽  
Zinaida Klestova ◽  
Viktor Tashuta
Keyword(s):  
In Vitro Toxicity ◽  
Toxicity Screening

In Vitro Screening for Hepatotoxicity of Xenobiotics using Isolated Hepatocytes

1988 ◽  
Vol 15 (3) ◽  
pp. 201-207
Author(s):  
Karel Lavrijsen ◽  
Derk Van Dijck ◽  
Jos Van Houdt ◽  
Ingrid Van Pelt ◽  
Willem Meuldermans ◽  
...  
Keyword(s):  
Culture Medium ◽  
Isolated Hepatocytes ◽  
Cell Number ◽  
Culture Conditions ◽  
Male Rats ◽  
In Vitro Toxicity ◽  
Toxicity Screening ◽  
Ldh Release

Isolated hepatocytes from male rats were cultured in primary cell culture in 24-well dishes for 20–24 hours in the presence of the various test compounds. Cytotoxicity at the end of the culture period was evaluated by the determination of LDH-release into the culture medium or by quantification of DNA content as a measure of the cell number in each well. Toxic xenobiotics, such as chlorpromazine, were able to induce LDH-release at up to 5 times the background levels at concentrations of 10-4–10-5 M. For most compounds, the increase in LDH-release was closely related to a decrease in cell number, as measured by the DNA method. Two culture conditions which might influence the cytotoxic response were investigated. Prolongation of the culture time increased the toxicity of some compounds, e.g. sodium dodecylsulphate, whereas for other compounds, e.g. amitriptyline, no change was noted. Addition of serum albumin and α1-acid glycoprotein decreased the toxicity of chlorpromazine to isolated hepatocytes. These results indicate that isolated hepatocytes might represent a useful in vitro toxicity screening system, and that careful standardisation of the culture conditions is necessary.

Human iPSC-derived retinal organoid model for in vitro toxicity screening

2021 ◽  
Vol 350 ◽  
pp. S45
Author(s):  
V. Chichagova ◽  
B. Dorgau ◽  
C. de Santis ◽  
M. Georgiou ◽  
M Carter ◽  
...  
Keyword(s):  
In Vitro Toxicity ◽  
Toxicity Screening ◽  
Human Ipsc

Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential

2001 ◽  
Vol 15 (4-5) ◽  
pp. 579-584 ◽  
Author(s):  
S.M Evans ◽  
A Casartelli ◽  
E Herreros ◽  
D.T Minnick ◽  
C Day ◽  
...  
Keyword(s):  
High Throughput ◽  
In Vitro Toxicity ◽  
Toxic Potential
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