scholarly journals OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes

ALTEX ◽  
2017 ◽  
pp. 311-315 ◽  
Author(s):  
Ellen Fritsche
Keyword(s):  
Test Methods ◽  
Developmental Neurotoxicity ◽  
Animal Test

Correlation of Animal Test Methods with Human Experience for Household Products

1984 ◽  
Vol 3 (1) ◽  
pp. 53-64 ◽  
Author(s):  
F. E. Freeberg ◽  
J. F. Griffith ◽  
R. D. Bruce ◽  
P. H. S. Bay
Keyword(s):  
Human Experience ◽  
Test Methods ◽  
Animal Test ◽  
Household Products

scholarly journals Assessing skin sensitization hazard in mice and men using non-animal test methods

2015 ◽  
Vol 71 (2) ◽  
pp. 337-351 ◽  
Author(s):  
Daniel Urbisch ◽  
Annette Mehling ◽  
Katharina Guth ◽  
Tzutzuy Ramirez ◽  
Naveed Honarvar ◽  
...  
Keyword(s):  
Test Methods ◽  
Skin Sensitization ◽  
Animal Test

Ocular Safety: A Silent (In Vitro) Success Story

2002 ◽  
Vol 30 (2_suppl) ◽  
pp. 69-74 ◽  
Author(s):  
Rodger D. Curren ◽  
John W. Harbell
Keyword(s):  
Raw Materials ◽  
Test Methods ◽  
In Vitro Tests ◽  
High Dose ◽  
Animal Testing ◽  
Animal Test ◽  
Ocular Irritation ◽  
Irritation Test ◽  
Dose Levels

Ocular irritation testing has been one of the animal test methods most criticised by animal welfare advocates. Additional criticism has arisen from within the scientific community, based on the variability of the animal test results and the questionable relevance of the extremely high dose levels employed. As a result, the Draize eye irritation test has been one of the main targets for in vitro replacement. Despite extensive efforts, however, there is still no in vitro method that is fully validated as a regulatory replacement. In spite of this, many individual companies are using diverse in vitro ocular irritation tests to gain important safety and efficacy information about their products and raw materials, eliminating the need for animal testing in the process. This is done in a safe fashion by applying intelligent testing paradigms. ECVAM has played a major role in this success, through its many programmes that have emphasised the importance of understanding the true toxicological need, and then using in vitro tests to provide that information. Thus, even in the absence of a successfully validated regulatory assay, the desired result of reducing animal testing is being met.

Overview of animal test methods for skin irritation

1985 ◽  
Vol 23 (2) ◽  
pp. 165-168 ◽  
Author(s):  
W. Gfeller ◽  
W. Kobel ◽  
G. Seifert
Keyword(s):  
Skin Irritation ◽  
Test Methods ◽  
Animal Test

scholarly journals Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

2015 ◽  
Vol 29 (1) ◽  
pp. 259-270 ◽  
Author(s):  
Kerstin Reisinger ◽  
Sebastian Hoffmann ◽  
Nathalie Alépée ◽  
Takao Ashikaga ◽  
Joao Barroso ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Test Methods ◽  
Systematic Evaluation ◽  
Animal Test ◽  
Skin Sensitisation

Assessing skin sensitization in mice and men using non-animal test methods

2015 ◽  
Vol 238 (2) ◽  
pp. S178
Author(s):  
S. Kolle ◽  
D. Urbisch ◽  
A. Mehling ◽  
N. Honarvar ◽  
T. Ramirez Hernandez ◽  
...  
Keyword(s):  
Test Methods ◽  
Skin Sensitization ◽  
Animal Test
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