scholarly journals Fate and Function of Human Embryonic Stem Cell-Derived GABAergic Progenitors in a Pilocarpine-Induced Temporal Lobe Epilepsy Mouse Model

2018 ◽  
Author(s):  
Nickesha Camille Anderson
Keyword(s):  
Stem Cell ◽  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Embryonic Stem Cell ◽  
Temporal Lobe ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
And Function

scholarly journals Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy

2009 ◽  
Vol 6 (2) ◽  
pp. 263-277 ◽  
Author(s):  
Xu Maisano ◽  
Joseph Carpentino ◽  
Sandy Becker ◽  
Robert Lanza ◽  
Gloster Aaron ◽  
...  
Keyword(s):  
Stem Cell ◽  
Temporal Lobe Epilepsy ◽  
Embryonic Stem Cell ◽  
Temporal Lobe ◽  
Embryonic Stem ◽  
Neural Precursor

scholarly journals Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Austin Thiel ◽  
Gregory Yavanian ◽  
Maria-Dorothea Nastke ◽  
Peter Morales ◽  
Nicholas A. Kouris ◽  
...  
Keyword(s):  
Stem Cell ◽  
Lupus Nephritis ◽  
Mouse Model ◽  
Embryonic Stem Cell ◽  
Kidney Function ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mesenchymal Cells

scholarly journals Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Ruchi Sharma ◽  
Sebastian Greenhough ◽  
Claire N. Medine ◽  
David C. Hay
Keyword(s):  
Liver Transplantation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Culture Media ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Bioartificial Liver ◽  
Tissue Culture Media ◽  
And Function

The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality. Presently, liver transplantation remains the only effective treatment, but donor availability is a major limitation. Therefore, artificial and bioartificial liver devices have been developed to bridge patients to liver transplantation. Existing support devices improve hepatic encephalopathy to a certain extent; however their usage is associated with side effects. The major hindrance in the development of bioartificial liver devices and cellular therapies is the limited availability of human hepatocytes. Moreover, primary hepatocytes are difficult to maintain and lose hepatic identity and function over time even with sophisticated tissue culture media. To overcome this limitation, renewable cell sources are being explored. Human embryonic stem cells are one such cellular resource and have been shown to generate a reliable and reproducible supply of human hepatic endoderm. Therefore, the use of human embryonic stem cell-derived hepatic endoderm in combination with tissue engineering has the potential to pave the way for the development of novel bioartificial liver devices and predictive drug toxicity assays.

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Diabetologia ◽  
2013 ◽  
Vol 56 (9) ◽  
pp. 1987-1998 ◽  
Author(s):  
Jennifer E. Bruin ◽  
Alireza Rezania ◽  
Jean Xu ◽  
Kavitha Narayan ◽  
Jessica K. Fox ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Pancreatic Progenitors ◽  
And Function
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