scholarly journals Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster

2015 ◽  
Vol 16 ◽  
pp. 83-98 ◽  
Author(s):  
Liang Chen ◽  
Liisa Heikkinen ◽  
K. Emily Knott ◽  
Yanchun Liang ◽  
Garry Wong
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Evolutionary Conservation ◽  
And Function

scholarly journals Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Ruchi Sharma ◽  
Sebastian Greenhough ◽  
Claire N. Medine ◽  
David C. Hay
Keyword(s):  
Liver Transplantation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Culture Media ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Bioartificial Liver ◽  
Tissue Culture Media ◽  
And Function

The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality. Presently, liver transplantation remains the only effective treatment, but donor availability is a major limitation. Therefore, artificial and bioartificial liver devices have been developed to bridge patients to liver transplantation. Existing support devices improve hepatic encephalopathy to a certain extent; however their usage is associated with side effects. The major hindrance in the development of bioartificial liver devices and cellular therapies is the limited availability of human hepatocytes. Moreover, primary hepatocytes are difficult to maintain and lose hepatic identity and function over time even with sophisticated tissue culture media. To overcome this limitation, renewable cell sources are being explored. Human embryonic stem cells are one such cellular resource and have been shown to generate a reliable and reproducible supply of human hepatic endoderm. Therefore, the use of human embryonic stem cell-derived hepatic endoderm in combination with tissue engineering has the potential to pave the way for the development of novel bioartificial liver devices and predictive drug toxicity assays.

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Diabetologia ◽  
2013 ◽  
Vol 56 (9) ◽  
pp. 1987-1998 ◽  
Author(s):  
Jennifer E. Bruin ◽  
Alireza Rezania ◽  
Jean Xu ◽  
Kavitha Narayan ◽  
Jessica K. Fox ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Pancreatic Progenitors ◽  
And Function

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

2020 ◽  
Author(s):  
Wamaitha SE ◽  
Grybel KJ ◽  
Alanis-Lobato G ◽  
Gerri C ◽  
Ogushi S ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Self Renewal
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