scholarly journals ALMOST OPEN AND ALMOST HOMEOMORPHISMS

2016 ◽  
Vol 29 (3) ◽  
pp. 397-416
Author(s):  
Gui Seok Kim ◽  
Kyung Bok Lee
Keyword(s):  
2021 ◽  
pp. 107823
Author(s):  
Alvaro Andrade ◽  
Javier Camargo
Keyword(s):  

2011 ◽  
Vol 17 (2) ◽  
pp. 87-108 ◽  
Author(s):  
Alexander Ullrich ◽  
Markus Rohrschneider ◽  
Gerik Scheuermann ◽  
Peter F. Stadler ◽  
Christoph Flamm

We developed a simulation tool for investigating the evolution of early metabolism, allowing us to speculate on the formation of metabolic pathways from catalyzed chemical reactions and on the development of their characteristic properties. Our model consists of a protocellular entity with a simple RNA-based genetic system and an evolving metabolism of catalytically active ribozymes that manipulate a rich underlying chemistry. Ensuring an almost open-ended and fairly realistic simulation is crucial for understanding the first steps in metabolic evolution. We show here how our simulation tool can be helpful in arguing for or against hypotheses on the evolution of metabolic pathways. We demonstrate that seemingly mutually exclusive hypotheses may well be compatible when we take into account that different processes dominate different phases in the evolution of a metabolic system. Our results suggest that forward evolution shapes metabolic network in the very early steps of evolution. In later and more complex stages, enzyme recruitment supersedes forward evolution, keeping a core set of pathways from the early phase.


2013 ◽  
Vol 6 (280) ◽  
pp. ec141-ec141
Author(s):  
N. R. Gough
Keyword(s):  

1998 ◽  
Vol 81 (6) ◽  
pp. 1286-1289 ◽  
Author(s):  
I. L. Aleiner ◽  
A. V. Andreev
Keyword(s):  

1986 ◽  
Vol 96 (2) ◽  
pp. 247-247
Author(s):  
Robin Harte ◽  
Martin Mathieu
Keyword(s):  

Subject Economic stimulus schemes and gaps. Significance The recent flow of economic data is putting numbers to the real-life experiences of a sudden stop in economic activity, a collapse in demand and soaring unemployment and corporate and consumer delinquencies. Countries have responded with monetary and fiscal stimulus packages, cushioning the worst damage of the crisis and stabilising financial markets somewhat. However, many gaps have appeared even though the 8 trillion dollars of fiscal stimulus programmes is larger than the 5 trillion dollars mobilised in 2008-09 and monetary accommodation by the US Federal Reserve (Fed) and ECB has become almost open-ended. Impacts Many emerging and developing countries will need more support, especially those unable to access the Fed's currency swap or repo facilities. Changes in consumer behaviour -- less eating out, travelling, gathering at events -- could persist longer than the pandemic. A battle over budgetary priorities between social groups and generations during the recovery could heighten social tension and discord.


Author(s):  
H. B. Moore

The Clyde Sea Area is in many ways an ideal ground for the investigation of the nutrient salts in the bottom deposits. The different lochs present a range of depth of water of from 0 to 200 metres: some parts have strong tidal currents up to five knots, while others are practically unaffected by the tide: some lochs have also been affected by the dumping of sewage and harbour sludge, and the effect of these can be examined. Conditions may also be compared in muds ranging from the loch heads to the almost open sea conditions at Ailsa Craig.


1989 ◽  
Vol 20 (3) ◽  
pp. 134-143
Author(s):  
P. Claassen ◽  
W. Backer

The rationalization of companies: Renewer or destroyer of the work-force. The rationalization of companies in the Western world has become almost an integrated part of modern management strategies. The downsizing syndrome has proven to be the favourite choice of many. Change, so many studies have proven, enhances resistance among employees. Change as experienced during the downsizing process, where retrenchment forms an inherent part of the strategy creates its own range of fears and expectations amongst employees. This study analyses the experiences of employees during the phases of destructive change. The hypothesis the study tested was that significantly more employees will rate the experience as extremely negative and that the main issue at stake is job security. It was found that although a significant proportion of the employees thought that drastic change was necessary, they were bitterly unhappy with the way management introduced the change. It was also found that at the centre of unhappiness, threats to job security caused the most damage. Furthermore, it was proven that during change, a well-planned, pre-programmed exercise, with a definite beginning and end time creates significantly lesser stress and fear amongst employees than during a unstructured almost open ended process.Die rasionalisering van ondernemings in die Westerse wereld het amper 'n geintegreerde deel van moderne bestuurstrategie geword. Die verskralingsindroom, so blyk dit, is die gewildste keuse onder bestuur. Dit is deur baie studies bewys, dat verandering een of ander vorm van weerstand onder werknemers kweek. Verandering, soos dit deurleef word tydens verskraling en waar personeelvermindering inherent aan die proses is, skep sy eie unieke reeks vrese en verwagtings onder werknemers. Hierdie studie analiseer die ondervindinge van werknemers tydens fases van destruktiewe verandering. Die hipotese wat getoets is, is dat beduidend meer werknemers die proses as uiters negatief sal ervaar en dat die grootste faktor wat negatiwiteit beinvloed werksekuriteitbedreiging sal wees. Daar is bevind dat alhoewel 'n beduidende aantal van die werknemers aangedui het dat verandering in hul organisasies noodsaaklik was, was hulle terselfdertyd bitter ongelukkig oor die wyse waarop verandering in die organisasie toegepas is. Daar is ook bevind dat die hoofoorsaak vir ongelukkigheid werksekuriteitbedreiging was. Vervolgens is daar statisties beduidende bewys dat goedbeplande, goedgestruktureerde veranderingspogings met 'n duidelike begin en 'n einde baie minder stress en ongelukkigheid veroorsaak as pogings wat onbeplan, ad hoc en amper tydloos van aard is.


2020 ◽  
Vol 35 (2) ◽  
Author(s):  
Morten Bøås ◽  
Mats Utas

The areas south of Libya have experienced more than their fair share of conflict and rapid social change. In earlier times, the main routes of trade, commerce and pilgrimage between West African and the Arab Peninsula passed through this region, also once inhabited by mighty warrior empires (see for example Bawuro 1972). However, as the empires along these routes faded away, and international ocean shipping opened up this part of Africa to the forces of global trade and capitalism, the centres of authority that once controlled this region also vanished. What remained was an almost open territory: unwelcoming and hard, but also a place of possibilities and the freedom to roam for those who had mastered the art of survival under such difficult conditions. This was the land of the Tuareg and other semi-nomadic groups who controlled cities and important trading posts such as Timbuktu, Gao and Kidal in contemporary Mali. This is the world of the Sahel and the parts of Western Africa that straddles Libya, and a region that currently includes Southern Algeria, Northern Mali, Niger, Chad, Mauritania and parts of Northern Nigeria. These are therefore also the countries and areas that have come to experience the full effect of what we define as post-Gaddafi repercussions.


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