scholarly journals A case of combination of two autoimmune diseases: type 1 diabetes mellitus and systemic scleroderma in a 13-year-old girl

2018 ◽  
Vol 64 (4) ◽  
pp. 231-234
Author(s):  
Elena V. Titovich ◽  
Ekaterina A. Andrianova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Single Case ◽  
Case Reports ◽  
Systemic Scleroderma ◽  
Unknown Etiology ◽  
Wall Thickening

Systemic scleroderma is an autoimmune disease of the connective tissue of unknown etiology. It is characterized by skin induration, lesions in the musculoskeletal system and the internal organs, and the Raynaud syndrome. An important component in pathogenesis of systemic scleroderma is disturbance of microcirculation involving endothelial proliferation and destruction, wall thickening and narrowing of the microvessel lumen, vasospasm, hemocyte aggregation, stasis, deformation and reduction of the capillary network (obliterating microangiopathy). Two main forms of the disease are distinguished: the diffuse and localized ones. The systemic nature of the diffuse form of systemic scleroderma is most obvious in the skin, but the digestive tract, respiratory organs, kidneys and the cardiovascular, endocrine, musculoskeletal and genitourinary systems are also affected. The incidence rate of systemic scleroderma is 6.3—12 cases per million population. Single case reports on scleroderma combined with other autoimmune diseases, including type 1 diabetes mellitus, in children and adolescents are available in literature. A rare case of a combination of two autoimmune diseases, type 1 diabetes mellitus and systemic scleroderma, in a 13-year-old girl is reported in this paper.

scholarly journals Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

2020 ◽  
Vol 11 ◽  
pp. 204201882095832
Author(s):  
Liyan Li ◽  
Shudong Liu ◽  
Junxia Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Autoimmune Thyroid

Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

Simultaneous peripubertal onset of multireactive autoimmune diseases with an unusual long-lasting remission of type 1 diabetes mellitus

2000 ◽  
Vol 53 (5) ◽  
pp. 649-653 ◽  
Author(s):  
Giuliana Valerio ◽  
Adriana Franzesé Andrea Iovino ◽  
Michela Tanga ◽  
Maria Alessio ◽  
Claudio Pignata
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus

scholarly journals Type 1 diabetes mellitus presenting as distal renal tubular acidosis (type 1)

2021 ◽  
Vol 8 (2) ◽  
pp. 283
Author(s):  
Ravi Kant ◽  
Mohit Garg ◽  
Mahendra Kumar Meena
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Renal Tubular Acidosis ◽  
Case Reports ◽  
Distal Renal Tubular Acidosis ◽  
Urinary Ph ◽  
Bilateral Lower Limb ◽  
Renal Tubular

A 42 year-old male patient known case of type 1 diabetes mellitus for last 15 years got admitted with bilateral lower limb swelling and poorly controlled diabetes. He was found to have alkaline urinary pH, persistent metabolic acidosis even after the correction of blood sugars without ketonuria or diabetic ketoacidosis and nephrocalcinosis thus he was diagnosed as distal renal tubular acidosis (RTA Type 1) and managed by alkali replacement with blood sugar control. The association of type-1 diabetes mellitus with type-1 RTA has been rarely reported in the literature, but there are various case reports which had linked with distal RTA with autoimmunity and destruction of DCT. As our case which was unusual as every type-1 diabetes doesn’t have acidosis due to DKA focused research is required in this field.  

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