Type 1 Diabetes Mellitus in Monogenic Autoimmune Diseases

2017 ◽  
pp. 78-90 ◽  
Author(s):  
Rosa Bacchetta ◽  
Maria Elena Maccari
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus

scholarly journals Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

2020 ◽  
Vol 11 ◽  
pp. 204201882095832
Author(s):  
Liyan Li ◽  
Shudong Liu ◽  
Junxia Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Autoimmune Thyroid

Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

Simultaneous peripubertal onset of multireactive autoimmune diseases with an unusual long-lasting remission of type 1 diabetes mellitus

2000 ◽  
Vol 53 (5) ◽  
pp. 649-653 ◽  
Author(s):  
Giuliana Valerio ◽  
Adriana Franzesé Andrea Iovino ◽  
Michela Tanga ◽  
Maria Alessio ◽  
Claudio Pignata
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus

scholarly journals Autoimmune diseases associated with type 1 diabetes mellitus: possible interplay

2013 ◽  
Vol 59 (1) ◽  
pp. 35-43 ◽  
Author(s):  
A A Larina ◽  
E A Troshina
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Metabolic Control ◽  
Early Diagnostics ◽  
Autoimmune Thyroid ◽  
Endocrine Diseases ◽  
Autoimmune Polyglandular Syndrome

Type 1 diabetes mellitus is not infrequently associated with other autoimmune endocrine and non-endocrine diseases included in the notion of "autoimmune polyglandular syndrome" (APS). Their incidence in the patients presenting with this syndrome is significantly higher than that of isolated autoimmune pathologies. The enhanced risk of the development of these diseases is associated with the presence of genetic markers, such as HLAII-complex haplotypes, CTLA-4, PTPN22, FOXP2, and certain other genes. Decompensation of autoimmune thyroid disorders and adrenal insufficiency, as well as the presence of celiac disease, autoimmune gastritis and pernicious anemia in the patients with type 1 diabetes mellitus may be responsible for the impairment of metabolic control. It is recommended that the patients with DM1 be regularly examined for the early diagnostics of autoimmune diseases including components of APS and the associated subclinical functional disturbances with a view to preventing deterioration of metabolic control.

scholarly journals A case of combination of two autoimmune diseases: type 1 diabetes mellitus and systemic scleroderma in a 13-year-old girl

2018 ◽  
Vol 64 (4) ◽  
pp. 231-234
Author(s):  
Elena V. Titovich ◽  
Ekaterina A. Andrianova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Single Case ◽  
Case Reports ◽  
Systemic Scleroderma ◽  
Unknown Etiology ◽  
Wall Thickening

Systemic scleroderma is an autoimmune disease of the connective tissue of unknown etiology. It is characterized by skin induration, lesions in the musculoskeletal system and the internal organs, and the Raynaud syndrome. An important component in pathogenesis of systemic scleroderma is disturbance of microcirculation involving endothelial proliferation and destruction, wall thickening and narrowing of the microvessel lumen, vasospasm, hemocyte aggregation, stasis, deformation and reduction of the capillary network (obliterating microangiopathy). Two main forms of the disease are distinguished: the diffuse and localized ones. The systemic nature of the diffuse form of systemic scleroderma is most obvious in the skin, but the digestive tract, respiratory organs, kidneys and the cardiovascular, endocrine, musculoskeletal and genitourinary systems are also affected. The incidence rate of systemic scleroderma is 6.3—12 cases per million population. Single case reports on scleroderma combined with other autoimmune diseases, including type 1 diabetes mellitus, in children and adolescents are available in literature. A rare case of a combination of two autoimmune diseases, type 1 diabetes mellitus and systemic scleroderma, in a 13-year-old girl is reported in this paper.

scholarly journals A case report of a boy suffering from type 1 diabetes mellitus and familial Mediterranean fever

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Maria Francesca Gicchino ◽  
Dario Iafusco ◽  
Angela Zanfardino ◽  
Emanuele Miraglia del Giudice ◽  
Alma Nunzia Olivieri
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Familial Mediterranean Fever ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Medical Literature ◽  
Periodic Fever ◽  
Mefv Gene ◽  
Mediterranean Fever

Abstract Background Type 1 diabetes mellitus could be associated with other autoimmune diseases, such as autoimmune thyroid disease, celiac disease, but the association with Familial Mediterranean Fever is rare, we describe a case of a boy with type 1 Diabetes Mellitus associated with Familial Mediterranean Fever (FMF). Case presentation A 13 year old boy already suffering from Diabetes Mellitus type 1 since the age of 4 years, came to our attention because of periodic fever associated with abdominal pain, chest pain and arthralgia. The fever appeared every 15–30 days with peaks that reached 40 °C and lasted 24–48 h. Laboratory investigation, were normal between febrile episodes, but during the attacks revealed an increase in inflammatory markers. Suspecting Familial Mediterranean Fever molecular analysis of MEFV gene, was performed. The genetic analysis showed homozygous E148Q mutation. So Familial Mediterranean Fever was diagnosed and colchicine treatment was started with good response. Conclusion Familial Mediterranean Fever could be associated with other autoimmune diseases such as Ankylosing Spondylitis, Rheumatoid Arthritis, Polyarteritis Nodosa, Behcet disease, Systemic Lupus, Henoch-Schönlein Purpura, and Hashimoto’s Thyroiditis. Association of type 1 Diabetes Mellitus and Familial Mediterranean Fever has been newly reported in the medical literature, this is the third association of these two diseases described in the medical literature so far.

Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

2015 ◽  
Vol 14 (9) ◽  
pp. 781-797 ◽  
Author(s):  
Kostas Kakleas ◽  
Alexandra Soldatou ◽  
Feneli Karachaliou ◽  
Kyriaki Karavanaki
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents
Sign in / Sign up

Export Citation Format

Share Document