scholarly journals Pituitary adenomas in the framework of hereditary syndromes

2014 ◽  
Vol 60 (4) ◽  
pp. 51-59 ◽  
Author(s):  
E O Mamedova ◽  
E G Przhiyalkovskaya ◽  
E A Pigarova ◽  
N G Mokrysheva ◽  
L K Dzeranova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Special Reference ◽  
Pituitary Adenomas ◽  
Present Review ◽  
Genetic Defects ◽  
Pituitary Neoplasms ◽  
Pituitary Tumours ◽  
Genetic Studies ◽  
Hereditary Syndromes

The overwhelming majority of the pituitary tumours are benign adenomas that remain a serious challenge to endocrinologists and neurosurgeons by virtue of great variety of their early manifestations, the impossibility to predict the neoplastic growth, and the influence exerted on the patients' quality of life. Most pituitary adenomas are sporadic tumours and only few of them develop in the framework of hereditary syndromes. The present review is focused on the variants of hereditary syndromes with special reference to various pituitary neoplasms. The molecular and genetic studies revealed several genetic defects that are believed to contribute to the formation of pituitary adenomas. Moreover, a few genes were identified responsible for the development of hereditary forms of pituitary tumours. Identification of such genes and pathogenetic mechanisms underlying the development of pituitary microadenomas is of paramount importance for the improvement of their diagnostics and treatment that in its turn may promote the understanding of pathogenesis of sporadic adenomas and improve their prognosis.

Nanotechnology: its application in treating Neurodegenerative diseases

2020 ◽  
Vol 19 ◽  
Author(s):  
Falaq Naz ◽  
Yasir Hasan Siddique
Keyword(s):  
Quality Of Life ◽  
Neurodegenerative Diseases ◽  
Blood Brain Barrier ◽  
Huntington Disease ◽  
Treatment Strategies ◽  
Present Review ◽  
Brain Barrier ◽  
Treatment Level ◽  
Blood Brain

: Neurodegenerative diseases including Alzheimer’s, Parkinson’s and Huntington disease are have serious concern due to its effect on the quality of life of affected persons. Neurodegenerative diseases have some limitations for both diagnostic as well as at treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly in solving the problem. There are several treatment strategies for the neurodegenerative diseases, but their limitations are the entry into the due to the presence of the blood-brain barrier (BBB). The present review highlights the application of nanotechnology during last 20 years for the treatment of neurodegenerative diseases.

Quality of life in terminal care—with special reference to age, gender and marital status

2005 ◽  
Vol 14 (4) ◽  
pp. 320-328 ◽  
Author(s):  
C. Lundh Hagelin ◽  
Åke Seiger ◽  
C. J. Fürst
Keyword(s):  
Quality Of Life ◽  
Marital Status ◽  
Special Reference ◽  
Terminal Care

Outcomes and quality of life assessment in patients undergoing endoscopic surgery for pituitary adenomas

2008 ◽  
Vol 22 (5) ◽  
pp. 630-635 ◽  
Author(s):  
K. Karabatsou ◽  
C. O'Kelly ◽  
A. Ganna ◽  
A. R. Dehdashti ◽  
F. Gentili
Keyword(s):  
Quality Of Life ◽  
Endoscopic Surgery ◽  
Pituitary Adenomas ◽  
Life Assessment ◽  
Quality Of Life Assessment

The Krüppel-like transcription factor 6 gene in sporadic pituitary tumours.

2003 ◽  
pp. 397-402 ◽  
Author(s):  
V V Vax ◽  
M Gueorguiev ◽  
I I Dedov ◽  
A B Grossman ◽  
M Korbonits
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Pituitary Adenomas ◽  
Small Subset ◽  
Tumour Suppressor Genes ◽  
Pituitary Neoplasms ◽  
Pituitary Tumours ◽  
Cell Cycle Protein ◽  
Exon 2 ◽  
Silent Substitution

The oncogenes and/or tumour suppressor genes which may be involved in the transformation process for the vast majority of pituitary tumours remain unknown. There is substantial evidence for derangement of cell cycle control in such tumours, but cell cycle protein mutations identified in other human malignancies are restricted to only a very small subset of sporadic pituitary neoplasms. Krüppel-like factors are DNA-binding transcriptional regulators with diverse effects including the upregulation of the cell cycle protein p21(WAF1/CIP1). It has been reported that the Krüppel-like transcription factor 6 (KLF6) gene is mutated in a proportion (15-55%) of human prostate cancers, and more recent data are emerging regarding mutated KLF6 in nasopharyngeal carcinomas, astrocytoid gliomas and colorectal cancer. We therefore speculated that other tumours such as pituitary adenomas might also harbour such mutations that may be involved in the control of cell proliferation in the pituitary. The aim of the current study was thus to analyse the KLF6 gene for mutations in sporadic pituitary tumours. We analysed 60 pituitary adenomas (15 GH-, four ACTH-, two PRL-secreting and 39 non-functioning) with direct sequence analysis of exons 2 and 3 of the KLF6 gene, the region where most of the previously described mutations are located. Three non-functioning pituitary adenomas of the 60 pituitary tumours (5%) had two identical sequence changes in exon 2 (missense mutation Val165Met, 523G-->A and a silent substitution in Ser77Ser codon 261C-->T). Analysis of genomic DNA extracted from peripheral lymphocytes in one patient confirmed these changes to be present in the germline and they therefore probably represent polymorphisms, although we cannot exclude the possibility that these are predisposing germline mutations. We conclude that mutations of the KLF6 gene are unlikely to play an important role in sporadic pituitary tumorigenesis.

An account of the quality of life of patients after treatment for non-functioning pituitary tumours

1997 ◽  
Vol 46 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Renee C. L. Page ◽  
Margaret S. Hammersley ◽  
Chris W. Burke ◽  
John A. H. Wass
Keyword(s):  
Quality Of Life ◽  
Pituitary Tumours

scholarly journals Challenges of Care giving Alzheimer’s Patients

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Vijayalakshmi, K ◽  
C. G. Venkatesha Murthy
Keyword(s):  
Quality Of Life ◽  
Quality Of Care ◽  
Review Paper ◽  
Present Review ◽  
Economic Problems ◽  
Care Giving ◽  
Increased Risk ◽  
Disease Condition ◽  
Successful Execution

The present review paper attempts to present the challenges faced by the caregivers when they assume care giving responsibilities for person/s affected with Alzheimer’s. The experiences in the context of care are not limited with physical and psychological domains alone. Rather care giving for Alzheimer’s involves increased risk of mental, emotional and economic problems as well as due to consequences of care giving that accompanies due to handling such a role. Ultimately the quality of care received by the person with Alzheimer’s and the quality of life of the caregiver becomes imbalance/impaired. Successful execution of the role in care giving brings harmony/balance in life between them in all dimensions of health which is highly essential. Therefore it demands the professionals to help the caregivers to understand about Alzheimer’s disease condition and to handle them based on felt- need to render the best care.

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