scholarly journals The results of the use of argon laser coagulation in the treatment of dibetic retinopathy

1998 ◽  
Vol 44 (4) ◽  
pp. 7-12
Author(s):  
T. M. Milenkaya ◽  
V. S. Terentyev ◽  
E. G. Bessmertnaya ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Argon Laser ◽  
Insulin Dependent Diabetes Mellitus ◽  
Late Results ◽  
Dependent Diabetes Mellitus ◽  
Laser Coagulation ◽  
Retinal Hemorrhages ◽  
Nonproliferative Diabetic Retinopathy ◽  
Insulin Dependent ◽  
Fundus Oculi

A total of 182 patients (95 men and 87 women) aged 15-49 years with insulin-dependent diabetes mellitus were treated using argon laser coagulation. Late results of laser therapy were followed up for 6 months to 3 years. In the patients with nonproliferative diabetic retinopathy (DR) on the fundus oculi the improvement consisted in partial resolution of solid exudative foci and retinal hemorrhages in 20%o of cases. In patients with preproliferative DR, soft exudative foci partially resolved and the number of retinal hemorrhages and microaneurysms decreased in 17%o of cases. In patients with proliferative DR, regressive development of proliferative tissue, desolation of newly formed vessels, and resolution of preretinal hemorrhages were observed in 13.9%o of cases. Stabilization for 3 years was attained in 75%) of patients with nonproliferative and proliferative and in 72.5%o of those with preproliferative DR.

scholarly journals Monitoring diabetic retinopathy in children with insulin-dependent diabetes mellitus

1998 ◽  
Vol 44 (3) ◽  
pp. 3-7
Author(s):  
T. M. Milenkaya ◽  
L. N. Shcherbacheva ◽  
V. A. Peterkova ◽  
V. S. Terentyev ◽  
V. P. Maksimova ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Laser Coagulation ◽  
Pathological Changes ◽  
Nonproliferative Diabetic Retinopathy ◽  
Proliferative Stage ◽  
The Status ◽  
Insulin Dependent

A total of 185 children (93 boys and 92 girls) aged 6 months to 15 years and disease duration of 1 to 13 years, residents of different regions of Russia, were examined. Pathological changes of the retina caused by diabetes were detected on the fundus oculi of 56 (30.3%) children. In 42 (22.7%)) of these, the initial changes (solitary retinal hemorrhages, microaneurysms) and in 14 (7.6%)) more pronounced micro- vascular pathological changes typical of nonproliferative diabetic retinopathy were detected, in 2 patients - the proliferative stage. Later argon coagulation of the retina was carried out in 10 patients with nonproliferative diabetic retinopathy and in 2 with proliferative diabetic retinopathy. The initial stages of nonproliferative and proliferative diabetic retinopathy are an indication for laser coagulation in children. The status of 6 (50%) children improved in remote periods (6-24 months) after laser coagulation: hemorrhages resolved and microaneurysms decreased; in 4 (33.3%) children the process was stabilized. Deterioration was observed in 2 (16. 7%o) children with nonproliferative and proliferative diabetic retinopathy.

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Interquartile Range ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Intergroup Comparison ◽  
Median Plasma ◽  
Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent
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