scholarly journals Graves’ disease in HIV patient receiving antiretroviral therapy

2020 ◽  
Vol 66 (3) ◽  
pp. 22-26
Author(s):  
Tatyana B. Morgunova ◽  
Anastasia A. Zorina ◽  
Ekaterina S. Maloletkina ◽  
Yulia P. Sytch ◽  
Ariadna V. Vasileva ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Thyroid Hormones ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Clinical Case ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Immune Reconstitution Syndrome ◽  
Highly Active ◽  
The World

The article focuses on the clinical case of Graves disease in a patient with HIV infection who is receiving antiretroviral therapy. The number of HIV-infected patients has increased significantly in recent decades all over the world. The currently used highly active antiretroviral therapy can significantly improve the prognosis for these patients. However, its use is associated with a number of complications, in particular the development of immune reconstitution syndrome, under which the development of such autoimmune diseases as Graves disease, polymyositis and Guillain-Barre syndrome may occur. Therefore, we would like to draw the attention of doctors to the possibility of such a complication in patients receiving antiretroviral therapy. Timely diagnosis and treatment of thyroid disorders will help to avoid the complications associated with an excess or deficit of thyroid hormones.

scholarly journals Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Samad Rasul ◽  
Robert Delapenha ◽  
Faria Farhat ◽  
Jhansi Gajjala ◽  
Syeda Mehreen Zahra
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immunological Response ◽  
Signs And Symptoms ◽  
Graves Disease ◽  
Typically Develop ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Haart Therapy

Graves' disease after the initiation of highly active antiretroviral therapy (HAART) in certain HIV-1-infected individuals has been described as an immune reconstitution inflammatory syndrome (IRIS). This phenomenon should be suspected in individuals who present with clinical deterioration and a presentation suggestive of hyperthyroidism despite good virological and immunological response to HAART. Signs and symptoms of hyperthyroidism may be discrete or overt and typically develop 8–33 months after initiating therapy. One to two percent of HIV-infected patients can present with overt thyroid disease. Relatively few cases of Graves' IRIS have been reported in the literature to date. We describe four cases of Graves' IRIS in HIV-infected patients who were started on HAART therapy.

Paradoxical recurrent meningitis following therapy of cryptococcal meningitis: an immune reconstitution syndrome after initiation of highly active antiretroviral therapy

2002 ◽  
Vol 13 (10) ◽  
pp. 724-726 ◽  
Author(s):  
Mark D King ◽  
Carl A Perlino ◽  
Jay Cinnamon ◽  
John A Jernigan
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cryptococcal Meningitis ◽  
Immune Reconstitution ◽  
Immune Reconstitution Syndrome ◽  
Recurrent Meningitis ◽  
Cryptococcal Infection ◽  
Highly Active ◽  
Previous Diagnosis ◽  
Histopathologic Findings

We report a case of paradoxical recurrent meningitis in response to initiation of highly active antiretroviral therapy in a patient receiving maintenance fluconazole for a previous diagnosis of cryptococcal meningitis. We describe the unusual radiographic and histopathologic findings which are consistent with an immune reconstitution induced paradoxical inflammatory response to residual cryptococcal infection.

scholarly journals CerebralMycobacterium aviumabscesses: Late immune reconstitution syndrome in an HIV-1-infected patient receiving highly active antiretroviral therapy

2005 ◽  
Vol 16 (3) ◽  
pp. 187-189 ◽  
Author(s):  
Claude Fortin ◽  
Danielle Rouleau
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immune Reconstitution Syndrome ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
The Central Nervous System ◽  
Brain Abscesses ◽  
Cd4 Cell ◽  
Suppurative Infection

A patient who developed an atypical manifestation ofMycobacterium aviumcomplex (MAC) infection almost two years after starting effective highly active antiretroviral therapy is described. The recurrence, manifested as brain abscesses in the central nervous system, was an uncommon form of MAC disease usually reported postmortem. An increased CD4 cell count, localized and suppurative infection, and the absence of systemic evidence of infection were consistent with a late immune reconstitution syndrome. The present case report adds to the understanding of MAC disease in HIV-infected patients.

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