Comment on “Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy” by Intalapaporn et al.

2007 ◽  
Vol 55 (1) ◽  
pp. 90-91
Author(s):  
Prasad R. Koduri
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Parvovirus B19 ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Immune Reconstitution Syndrome ◽  
Red Cell Aplasia ◽  
Highly Active

Paradoxical recurrent meningitis following therapy of cryptococcal meningitis: an immune reconstitution syndrome after initiation of highly active antiretroviral therapy

2002 ◽  
Vol 13 (10) ◽  
pp. 724-726 ◽  
Author(s):  
Mark D King ◽  
Carl A Perlino ◽  
Jay Cinnamon ◽  
John A Jernigan
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cryptococcal Meningitis ◽  
Immune Reconstitution ◽  
Immune Reconstitution Syndrome ◽  
Recurrent Meningitis ◽  
Cryptococcal Infection ◽  
Highly Active ◽  
Previous Diagnosis ◽  
Histopathologic Findings

We report a case of paradoxical recurrent meningitis in response to initiation of highly active antiretroviral therapy in a patient receiving maintenance fluconazole for a previous diagnosis of cryptococcal meningitis. We describe the unusual radiographic and histopathologic findings which are consistent with an immune reconstitution induced paradoxical inflammatory response to residual cryptococcal infection.

scholarly journals CerebralMycobacterium aviumabscesses: Late immune reconstitution syndrome in an HIV-1-infected patient receiving highly active antiretroviral therapy

2005 ◽  
Vol 16 (3) ◽  
pp. 187-189 ◽  
Author(s):  
Claude Fortin ◽  
Danielle Rouleau
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immune Reconstitution Syndrome ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
The Central Nervous System ◽  
Brain Abscesses ◽  
Cd4 Cell ◽  
Suppurative Infection

A patient who developed an atypical manifestation ofMycobacterium aviumcomplex (MAC) infection almost two years after starting effective highly active antiretroviral therapy is described. The recurrence, manifested as brain abscesses in the central nervous system, was an uncommon form of MAC disease usually reported postmortem. An increased CD4 cell count, localized and suppurative infection, and the absence of systemic evidence of infection were consistent with a late immune reconstitution syndrome. The present case report adds to the understanding of MAC disease in HIV-infected patients.

scholarly journals Graves’ disease in HIV patient receiving antiretroviral therapy

2020 ◽  
Vol 66 (3) ◽  
pp. 22-26
Author(s):  
Tatyana B. Morgunova ◽  
Anastasia A. Zorina ◽  
Ekaterina S. Maloletkina ◽  
Yulia P. Sytch ◽  
Ariadna V. Vasileva ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Thyroid Hormones ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Clinical Case ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Immune Reconstitution Syndrome ◽  
Highly Active ◽  
The World

The article focuses on the clinical case of Graves disease in a patient with HIV infection who is receiving antiretroviral therapy. The number of HIV-infected patients has increased significantly in recent decades all over the world. The currently used highly active antiretroviral therapy can significantly improve the prognosis for these patients. However, its use is associated with a number of complications, in particular the development of immune reconstitution syndrome, under which the development of such autoimmune diseases as Graves disease, polymyositis and Guillain-Barre syndrome may occur. Therefore, we would like to draw the attention of doctors to the possibility of such a complication in patients receiving antiretroviral therapy. Timely diagnosis and treatment of thyroid disorders will help to avoid the complications associated with an excess or deficit of thyroid hormones.

scholarly journals Parvovirus B19 infection in HIV-infected patients

2020 ◽  
Vol 92 (7) ◽  
pp. 100-103
Author(s):  
A. A. Petrenko ◽  
G. A. Dudina ◽  
N. V. Kremneva ◽  
A. V. Pivnik
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Parvovirus B19 ◽  
Pure Red Cell Aplasia ◽  
Intravenous Immunoglobulins ◽  
Normocytic Anemia ◽  
Red Cell ◽  
Test Results ◽  
Red Cell Aplasia ◽  
Laboratory Test Results

Here we provide a review of the literature and a description of our own clinical case. The patient was a 32-year-old woman who had been infected with HIV for 6 years without antiretroviral therapy. The test results showed CD4 87 cells/l, viral load 3750 copies/ml. Normochromic normocytic anemia and reticulocytopenia developed soon. In the myelogram, all erythroblasts were 0.5%. The viral load of parvovirus B19 DNA according to PCR was more than 9 million IU/ml. Pure red cell aplasia associated with parvovirus B19 was diagnosed. We started antiretroviral therapy with efavirenz, lamevudine and tenofovir. In addition to blood transfusions, we administered intravenous donor immunoglobulin with a dose increase from 5000 mg to 20 000 mg per day. After discontinuing of intravenous immunoglobulins, the laboratory test results were stable over the next 5 months: hemoglobin was more than 115 g/L, reticulocytes more than 3%, in the myelogram all erythroblasts were 21%. However, the elimination of parvovirus B19 wasnt achieved. The maximum decrease in viral load for parvovirus B19 was down to 720 IU/ml. A typical feature of the case was the lack of pure red cell aplasia of the bone marrow with the existing viral load of parvovirus B19. HIV infection progressed: 44 cells/l, viral load not determined. The case ended lethally.

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