scholarly journals Activities of the anterior hypothalamus neurosecretory nuclear enzymes in exposure to organophosphorus compounds

1993 ◽  
Vol 39 (2) ◽  
pp. 49-51
Author(s):  
N. К. Shamsiyeva ◽  
A. A. Khusinov
Keyword(s):  
Organophosphorus Compounds ◽  
White Male ◽  
Hydrolytic Enzymes ◽  
Neurosecretory Cells ◽  
Neurosecretory Material ◽  
Alkaline Phosphatases ◽  
Enzymes Activities ◽  
Cell Dysfunction ◽  
Neurosecretory Nuclei ◽  
Almost All

Under study were activities of glycolysis enzymes: LDH, Crebs cycle SDH, those of electron transport system NAD and NADP-diaphorase, and of the hydrolytic enzymes, acid and alkaline phosphatases in the hypothalamus, as were morphofunctional shifts in these enzymes activities in poisoning with organophosphorus compounds. The experiments were carried out in 72 white male outbread rats weighing 180-200 g, that were administered PHOS antio (an organophosphorus compound) in a daily dose of 0.1 LD50 for 30 days. Early dates of poisoning were associated with an essential rise of the redox enzymes and a lowering of the hydrolytic enzymes levels, this being parallelled by morphologic signs of activation of the neurosecretory cells. Later high levels of neurosecretory material in the neurosecretory nuclei and reduced counts of neurosecretory cells were coupled with almost all the enzymes activities lowering. This permits a conclusion that changed activities of the enzymic systems may be one of the pathogenetic mechanisms and possible causes of neurosecretory cell dysfunction in pesticide poisonings

scholarly journals ‘Ruined’ lives: Mediated white male victimhood

2021 ◽  
Vol 24 (1) ◽  
pp. 60-80
Author(s):  
Sarah Banet-Weiser
Keyword(s):  
Social Media ◽  
Sexual Harassment ◽  
Sexual Violence ◽  
Public Perception ◽  
White Male ◽  
The Public ◽  
Multi Media ◽  
Patriarchal Power ◽  
Almost All ◽  
False Accusations

When the hashtag #metoo began to circulate in digital and social media, it challenged a familiar interpretation of those who are raped or sexually harassed as victims, positioning women as embodied agents. Yet, almost exactly a year after the #metoo movement shot to visible prominence, a different, though eerily similar, story began to circulate on the same multi-media platforms as #metoo: a story about white male victimhood. Powerful men in positions of privilege (almost always white) began to take up the mantle of victimhood as their own, often claiming to be victims of false accusations of sexual harassment and assault by women. Through the analysis of five public statements by highly visible, powerful men who have been accused of sexual violence, I argue that the discourse of victimhood is appropriated not by those who have historically suffered but by those in positions of patriarchal power. Almost all of the statements contain some sentiment about how the accusation (occasionally acknowledging the actual violence) ‘ruined their life’, and all of the statements analyzed here center the author, the accused white man, as the key subject in peril and the authors position themselves as truth-tellers about the incidents. These statements underscore certain shifts in the public perception of sexual violence; the very success of the #metoo movement in shifting the narrative has meant that men have had to defend themselves more explicitly in public. In order to wrestle back a hegemonic gender stability, these men take on the mantle of victimhood themselves.

Enzymes and Their Forms Used in Detection of Organophosphorus Compounds

2021 ◽  
pp. 22-41
Keyword(s):  
Organophosphorus Compounds ◽  
Degradation Products ◽  
Rapid Development ◽  
Hydrolytic Enzymes ◽  
Immobilized Enzymes ◽  
Amino Acid Sequences ◽  
Practical Implementation ◽  
Scientific Results ◽  
Physical And Chemical

Еnzymes are able to effectively interact with various organophosphorus compounds (OPC), entering into (bio)chemical reactions with them. Changes in the initial activity of enzymes as a result of their inhibition by OPC, the formation of OPC degradation products under the action of hydrolytic enzymes, etc. can be determined using different physical and chemical methods and used in bioanalytic systems to determine the concentrations of OPC. The purpose of the review is to analyze the main scientific results achieved over the past 10 years in the development of analytical systems based on enzymes intended for the determination of OPC. It is shown in the article, that the requirements for the sensitivity of biosensors are based on the norms of the content of the analyzed substances detected in/at the objects of mandatory control. The cholinesterases compose a basis for the development of the largest number of ultra-sensitive biosensors, although other enzymes can be successfully used as a biosensitive element. The most technologically advanced solution that is close to the practical implementation seems to be bioanalytical systems using immobilized enzymes. Improving the detection limits of the OPC can be achieved by using nanoobjects together with modern methods of signal transducers, for example, with nanomechanical detectors and signal converters. This combination of technical solutions ensures the sensitivity of the OPC analysis up to pg/l. At present, «reagentless» systems have received significant development, which have become the basis for the production of a large number of commercially available strips for the express determination of OPC. Modern demands stimulate the rapid development of portable and, especially, wearable biosensors that can be attached to various surfaces, including a clothing. The progress in the development of affine amino acid sequences, in the future, will allow the creation of enzyme biosensors on any surface.

The Stomodaeal Nervous System, Neurosecretion, and Related Endocrine and Nervous Structures in Aedes aegypti (L.) (Diptera: Culicidae)

1964 ◽  
Vol 96 (1-2) ◽  
pp. 105-106 ◽  
Author(s):  
L. Burgess ◽  
J. G. Rempel
Keyword(s):  
Nervous System ◽  
Aedes Aegypti ◽  
Common Property ◽  
Neurosecretory Cells ◽  
Corpora Allata ◽  
Prothoracic Gland ◽  
Neurosecretory Material ◽  
Purple Colour ◽  
Aldehyde Fuchsin ◽  
The Common

This exhibit represents some portions of a study of the stomodaeal nervous system, neurosecretory cells, corpora allata, corpora cardiaca, and prothoracic gland cells in post-embryonic stages of Aedes aegypti (L.), the yellow fever mosquito. Some of these structures share the common property of being involved in the production of hormones.Mosquitoes were reared under standard conditions. Larvae, pupae and adults were fixed at timed intervals in histological fixatives. Sectioned specimens were stained in Gomori's aldehyde-fuchsin, Gomori's chrome-haematoxyh-phloxin and other stains. The aldehyde-fuchsin technique, which imparted a bright purple colour to neurosecretory material, was particularly useful. Vita1 staining with methylene blue was used to trace the stomodaeal nervous system

The effect of feeding on the cerebral neurosecretory system of the adult male tsetse, Glossina austeni Newst

1978 ◽  
Vol 56 (9) ◽  
pp. 1988-1992 ◽  
Author(s):  
M. Grossman ◽  
K. G. Davey
Keyword(s):  
Adult Male ◽  
Neurosecretory Cells ◽  
Neurosecretory System ◽  
Neurosecretory Material ◽  
Corpus Cardiacum ◽  
Pars Intercerebralis ◽  
Corpora Cardiaca ◽  
Glossina Austeni ◽  
Effect Of Feeding

An analysis of the intensity of staining of the corpus cardiacum and of the neurosecretorty cells of the pars intercerebralis in 3-day-old fed or fasting adult male tsetse has revealed two periods of apparent release of neurosecretion. In fed males, stainable neurosecretion disappears from 14 of the 20 recognizable neurosecretory cells within 10 min of the termination of feeding. There is always less neurosecretory material in the corpora cardiaca of fed males. Secondly, there is an indication of a depletion of material from the cardiaca of both fed and fasted males at about 1700 hours EST.

scholarly journals Exosome microRNAs in Metabolic Syndrome as Tools for the Early Monitoring of Diabetes and Possible Therapeutic Options

2021 ◽  
Vol 14 (12) ◽  
pp. 1257
Author(s):  
Erika Cione ◽  
Roberto Cannataro ◽  
Luca Gallelli ◽  
Giovambattista De Sarro ◽  
Maria Cristina Caroleo
Keyword(s):  
Essential Role ◽  
Cell Injury ◽  
Cell Types ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Dysfunction ◽  
Pathological Conditions ◽  
Novel Approach ◽  
Almost All

Exosomes are nano-sized extracellular vesicles produced and released by almost all cell types. They play an essential role in cell–cell communications by delivering cellular bioactive compounds such as functional proteins, metabolites, and nucleic acids, including microRNA, to recipient cells. Thus, they are involved in various physio-pathological conditions. Exosome-miRNAs are associated with numerous diseases, including type 2 diabetes, a complex multifactorial metabolic disorder linked to obesity. In addition, exosome-miRNAs are emerging as essential regulators in the progression of diabetes, principally for pancreatic β-cell injury and insulin resistance. Here, we have clustered the recent findings concerning exosome-miRNAs associated with β-cell dysfunction to provide a novel approach for the early diagnosis and therapy of diabetes.

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