scholarly journals Contribution of parotitis virus to the development of insulin-dependent diabetes mellitus

1993 ◽  
Vol 39 (5) ◽  
pp. 14-16
Author(s):  
T. I. Severina ◽  
V. Ye. Kolpakova ◽  
N. Ya. Venediktova ◽  
O. N. Ilyasova ◽  
L. G. Akhmedyanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Autoimmune Process ◽  
Antibody Titers ◽  
Insulin Dependent ◽  
Epidemic Parotitis ◽  
The Relationship ◽  
P Cells

Viral infection is one of the factors provoking the development of insulin-dependent diabetes mellitus (IDDM). Epidemic parotitis more frequently than other infections is connected with IDDM manifestations, but the results of examinations of convalescents after epidemic parotitis and of patients with newly diagnosed IDDM are contradictory. Parotitis viruses are believed to injure pancreatic p-cells and trigger on the autoimmune process in carriers of certain antigens. In none of the 200 cases of IDDM manifestation a relationship with epidemic parotitis was established and none of the 268 convalescents after epidemic parotitis developed IDDM. Screening for antibodies to epidemic parotitis virus carried out in 61 patients with newly detected IDDM revealed low antibody titers in the majority (83.3 %); HLA-B8 antigen was detected in 23 % of these examinees. In the group of subjects with persistent high antibody titers and their diagnostic increment or reduction HLA-BS antigen was found in only 12.5 %. These results do not permit a conclusion on the relationship between IDDM manifestation and parotitis infection.

Autoimmune process markers in insulin-dependent diabetes mellitus

2019 ◽  
Vol 43 (3) ◽  
pp. 13-16
Author(s):  
F. A. Galenok ◽  
Ye. A. Zhuk
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Manifestations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Autoimmune Process ◽  
Course Of Disease ◽  
Cell Immunity ◽  
Insulin Dependent ◽  
Nbt Reduction

Quantitative and functional parameters of the monocyte and В-cell immunity were assessed in patients with insulin-dependent diabetes over the course of disease. Studies of the monocyte component in subjects predisposed to disease and of the humoral one in those with clinical manifestations are valuable for predicting the autoimmune process. Signs predicting a poor outcome are increase of the count of Fc-positive cells, decrease of NBT reduction of monocytes in subjects without signs of the disease, high levels of immunoglobulin G in manifest disease, and increase of IgM and B-lymphopcyte count and decrease of IgA over the course of the disease.

Cardiosympathetic Neuropathy is Independent of Cardioparasympathetic Neuropathy in Patients with Non-Insulin-Dependent Diabetes Mellitus

1995 ◽  
Vol 23 (5) ◽  
pp. 364-368
Author(s):  
S Okada ◽  
S Tanokuchi ◽  
T Higuchi ◽  
Y Ogino ◽  
K Ichiki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Nerve Function ◽  
Deep Breathing ◽  
Coefficients Of Variation ◽  
Insulin Dependent ◽  
The Relationship

The relationship between cardiosympathetic neuropathy and cardioparasympathetic neuropathy was investigated in 103 patients with non-insulin-dependent diabetes mellitus. Cardioparasympathetic nerve function was assessed by comparing electrocardiographically the expiratory and inspiratory R-R interval ratios, during a period of deep breathing, and the coefficients of variation of the R-R intervals. Cardiosympathetic nerve function was assessed by determining the uptake of [123I]metaiodobenzyl guanidine into the myocardium. The results indicate that there is no significant correlation between cardioparasympathetic and cardiosympathetic nerve function.

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