Autoimmune process markers in insulin-dependent diabetes mellitus

2019 ◽  
Vol 43 (3) ◽  
pp. 13-16
Author(s):  
F. A. Galenok ◽  
Ye. A. Zhuk
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Manifestations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Autoimmune Process ◽  
Course Of Disease ◽  
Cell Immunity ◽  
Insulin Dependent ◽  
Nbt Reduction

Quantitative and functional parameters of the monocyte and В-cell immunity were assessed in patients with insulin-dependent diabetes over the course of disease. Studies of the monocyte component in subjects predisposed to disease and of the humoral one in those with clinical manifestations are valuable for predicting the autoimmune process. Signs predicting a poor outcome are increase of the count of Fc-positive cells, decrease of NBT reduction of monocytes in subjects without signs of the disease, high levels of immunoglobulin G in manifest disease, and increase of IgM and B-lymphopcyte count and decrease of IgA over the course of the disease.

scholarly journals Contribution of parotitis virus to the development of insulin-dependent diabetes mellitus

1993 ◽  
Vol 39 (5) ◽  
pp. 14-16
Author(s):  
T. I. Severina ◽  
V. Ye. Kolpakova ◽  
N. Ya. Venediktova ◽  
O. N. Ilyasova ◽  
L. G. Akhmedyanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Autoimmune Process ◽  
Antibody Titers ◽  
Insulin Dependent ◽  
Epidemic Parotitis ◽  
The Relationship ◽  
P Cells

Viral infection is one of the factors provoking the development of insulin-dependent diabetes mellitus (IDDM). Epidemic parotitis more frequently than other infections is connected with IDDM manifestations, but the results of examinations of convalescents after epidemic parotitis and of patients with newly diagnosed IDDM are contradictory. Parotitis viruses are believed to injure pancreatic p-cells and trigger on the autoimmune process in carriers of certain antigens. In none of the 200 cases of IDDM manifestation a relationship with epidemic parotitis was established and none of the 268 convalescents after epidemic parotitis developed IDDM. Screening for antibodies to epidemic parotitis virus carried out in 61 patients with newly detected IDDM revealed low antibody titers in the majority (83.3 %); HLA-B8 antigen was detected in 23 % of these examinees. In the group of subjects with persistent high antibody titers and their diagnostic increment or reduction HLA-BS antigen was found in only 12.5 %. These results do not permit a conclusion on the relationship between IDDM manifestation and parotitis infection.

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Interquartile Range ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Intergroup Comparison ◽  
Median Plasma ◽  
Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent
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