scholarly journals New approaches to treating diabetic peripheral polyneuropathy in children and adolescents

2003 ◽  
Vol 49 (5) ◽  
pp. 11-16
Author(s):  
G. I. Sivous
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Lipoic Acid ◽  
Lower Extremities ◽  
Neurological Symptoms ◽  
Good Tolerability ◽  
New Approaches ◽  
Impairment Score ◽  
Peripheral Polyneuropathy ◽  
Daily Dose

А hundred and seven patients (56 males and 51 females) aged 8 to 21 years who had suclinical and mild diabetic peripheral polyneuropathy received pathogenetic treatment. Thirty-nine patients took a combined drug including benfotiamine and pyridoxine in a daily dose of 300 mg for 6 weeks. Twenty-three and 45 patients were given a-lipoic acid in a daily dose of 10-15 mg/kg body weight for 8 and 12 weeks, respectively. The treatment was monitored by using the Total Symptoms Score and the Neuropathy Impairment Score for the Lower Extremities, stimulation electromyography of two nerves of the leg. The therapy showed significant positive changes in subjective and objective neurological symptoms and baseline altered indices, a good tolerability of all the drugs. The findings allow one to consider a-lipoic acid and "millegamma " as tablets to be an agent for the treatment of subclinical and mild forms of diabetic peripheral polyneuropathy.

scholarly journals Diabetic polyneuropathy in children and adolescents: clinical picture and diagnosis

2003 ◽  
Vol 49 (6) ◽  
pp. 3-8
Author(s):  
G. I. Sivous ◽  
I. A. Strokov ◽  
I. V. Galeyev ◽  
E. P. Kasatkina
Keyword(s):  
Children And Adolescents ◽  
Neurological Examination ◽  
Age Groups ◽  
Diabetic Polyneuropathy ◽  
Childhood And Adolescence ◽  
Medical Academy ◽  
Impairment Score ◽  
Peripheral Polyneuropathy ◽  
History Of ◽  
Motor Nerves

The Department of Childhood and Adolescence Endocrinology, Russian Medical Academy of Postgraduate Training, Ministry of Health of the Russian Federation, examined 529 patients with type 1 diabetes mellitus (DM) whose age was 5 to 22 years. The study was undertaken to examine the prevalence and severity of diabetic peripheral polyneuropathy (DPN) in children, adolescents, and young individuals who fell ill with DM in childhood, to characterize the symptoms and neurological manifestations of this complication, and to choose adequate studies for their examination. DPN is most common in adolescents and young individuals having a longer history of the disease and worse values of compensation of carbohydrate metabolism. The specific feature of DPN in these age groups are the absence of severe forms of the disease and the presence of mainly the sensory pattern of disorders. The study defined the required scope of a neurological examination for early diagnosis of DPN in children and adolescents, which should include a thorough analysis of a patient’s complaints and a test by the Total Symptoms Score, a neurological examination by the modified Neuropathy Impairment Score for the Lower Extremities, stimulation electromyography of the sensory and motor nerves of the leg. By taking into account a poor DM compensation in the absolute majority of children and adolescents, the neurological examination should be regular at least once a year.

Effectiveness of a Multidisciplinary Lifestyle Intervention to Reduce Obesity among Children and Adolescents

2020 ◽  
Vol 35 (2) ◽  
pp. 111-118
Author(s):  
Md Rizwanul Ahsan ◽  
Sabrina Makbul ◽  
Probir Kumar Sarkar
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Children And Adolescents ◽  
Physical Performance ◽  
Cardiometabolic Risk ◽  
Dietary Habits ◽  
Obese Children ◽  
Height Ratio ◽  
Waist To Height Ratio ◽  
Family Based

Background: Now a days unhealthy lifestyle primarily responsible for the dramatic increase obesity among children and adolescents. Objective: The purpose of the study is to see the effects of a multidisciplinary lifestyle intervention to reduce obese children and adolescents. The main outcome was cardiometabolic risk based on the waist-to-height ratio (WHTR) measurement. Secondary outcomes were (1) changes in body composition; (2) adherence to a Mediterranean diet; and (3) physical performance. Methods: The study involved 64 overweight/obese children or adolescents conducted at Dhaka Shishu Hospital from October 2017 to September 2018. The intervention was multidisciplinary including nutrition, exercise, and psychological aspects based on a family-based approach; it was delivered for six months for children and three months for adolescents. Before and after the intervention, several anthropometric measures height, body weight, body mass index (BMI), waist circumference, and body composition, cardiometabolic risk index waist-to-height ratio (WHTR), and dietary habits of the participants and their families were evaluated. In addition, a set of functional motor fitness tests was performed to evaluate physical performance measures. Results: After the intervention both children and adolescents showed a significant reduction in body weight, BMI, waist circumference, fat mass, and WHTR index and an improvement of fat-free mass, adherence to the Mediterranean diet, and physical fitness performance. Conclusion: A short term family-based multidisciplinary approach is effective in ameliorating the health status, dietary habits, and physical performance in children and adolescents. DS (Child) H J 2019; 35(2) : 111-118

Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents

2000 ◽  
Vol 37 (2) ◽  
pp. 93-101 ◽  
Author(s):  
F. Oeffner ◽  
D. Bornholdt ◽  
A. Ziegler ◽  
A. Hinney ◽  
T. Görg ◽  
...  
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Neuromedin B ◽  
German Children

scholarly journals Lower-caloric intake but different nutrient profiles in cognition impaired and in frail elderlies

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Y Wu ◽  
W H Pan
Keyword(s):  
Body Weight ◽  
Cognitive Impairment ◽  
Dietary Fiber ◽  
Energy Intake ◽  
Odds Ratio ◽  
Nutrient Intake ◽  
Lower Energy ◽  
Trend Test ◽  
Impairment Score ◽  
Cognition Impairment

Abstract Background Frailty and dementia are two common geriatric syndromes associated with poor nutritional status. The nutritional role in the pathogenesis of frailty and dementia remains unclear. We examined the associations between energy intake and frailty/cognition impairment and also compared the nutrient intake between frail and cognition impaired elderlies by sex. Methods Data of 1,920 elderly adults (≧65y) from the 2014-2017 Nutrition and Health Survey in Taiwan was used. Frailty was defined using modified L. Fried criteria. The Chinese Mini-Mental State Examination score was grouped into tertiles: cognitive impairment (score ≦ 23), mild cognitive impairment (score = 24-27), and the normal (score ≧28). Total energy intake was grouped into tertiles. Logistic regression adjusted for age, sex, and sampling strata was used for association test. The trend test was performed using generalized linear model with age adjustment to examine whether various nutrient intake indicators had an ordered relationship with the severity of frailty and cognitive impairment. Results Lower energy intake (men <1540 Kcal or women<1182 Kcal) was significantly associated with frailty (odds ratio [OR]: 1.97; 95% confidence interval [CI]: 1.45-2.66) and cognition impairment (OR: 1.88; 95%CI: 1.43-2.47), respectively. Larger number of micronutrients and food substances per Kg body weight exhibited decreasing trends with MCI (protein, fat, carbohydrate, vitamins B1, B2, B3, B6, B12, C, E, Ca, P, Fe, Mg, K, Zn, dietary fiber, and cholesterol) than with frailty (protein, vitamin B1, B3, B6, C, P, Mg, K, Zn, polyunsaturated fatty acids, and dietary fiber). Conclusions The lower the energy intake, the higher the odds ratio for frailty and for dementia. Dietary quality expressed by nutrient intake per Kg body weight was poorer in elderlies with cognition impairment than those with frailty. Key messages Lower energy intake is associated with MCI and with frailty, respectively. The MCI elderlies involve more micronutrient deficiencies than the frail counterpart.

scholarly journals Medical and non-medical complications among children and adolescents with excessive body weight

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Albane BR Maggio ◽  
Xavier E Martin ◽  
Catherine Saunders Gasser ◽  
Claudine Gal-Duding ◽  
Maurice Beghetti ◽  
...  
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Medical Complications ◽  
Excessive Body Weight

Abstract P088: Obesity, Hypertension and Insulin Resistance in a Primary Pediatric Setting in Southern Italy

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Giampaolo De Filippo ◽  
Domenico Rendina ◽  
Domenico Viggiano ◽  
Antonio Fasolino ◽  
Paola Sabatini ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Children And Adolescents ◽  
Diagnostic Criteria ◽  
Southern Italy ◽  
Serum Insulin ◽  
High Density Lipoproteins ◽  
Obese Children ◽  
Campania Region

Background: Obesity is the main risk factor for essential hypertension (EH) in childhood. The O.Si.Me. study (Obesity and Metabolic Syndrome in children and adolescents) evaluated the prevalence of metabolic syndrome (MetS) and its constitutive traits in a sample of obese children and adolescents living in Campania, southern Italy. Patients and methods: Four hundred and fifteen children and adolescents consecutively referred to the National Health Service participating Outpatient Clinics for minor health problems and found to have a Body Mass Index (BMI) Z-score > 2.0 were enrolled in the study. The entire sample was screened for MetS, which was defined as the presence of at least 2 of the following alterations in addition to obesity: fasting hyperglycemia, low levels of high-density lipoproteins cholesterol, hypertriglyceridemia, and EH. The present analysis evaluated the clinical characteristics of the O.Si.Me subgroup of EH participants (systolic and/or diastolic BP ≥ 95 th percentile for age, gender and height) as compared with normotensive participants. Results: The prevalence of EH in the O.Si.Me population was 23.6 % (98/415, 48M and 50F.) and two-thirds of the EH participants met the MetS diagnostic criteria. The EH participants featured serum insulin and HOMA-IR levels significantly higher compared with normotensive ones (11.6±0.6 vs. 9.5±0.4 μIU/ml, p = 0.014; 2.6±0.1 vs. 2.2±0.1, p = 0.028 for insulin and HOMA-IR, respectively). These differences were common to boys and girls and remained significant after correction for age, pubertal stage, body weight, length, BMI, gestational age at birth, duration of breastfeeding and anthropometric parental parameters. Accordingly, children and adolescents with EH had a a relative risk of being insulin resistant (defined as a HOMA-IR ≥2.5) significantly greater compared to those without. Moreover, they exhibited higher serum creatinine levels (53.8±7.1 vs. 35.4±6.8 μmol/l, p=0.025) accounting for gender and body weight. Conclusions: More than a quarter of obese children and adolescents meet the diagnostic criteria for EH in the Campania region in southern Italy. These obese boys and girls have an increased prevalence of insulin resistance and apparently an initial reduction in renal function compared with obese children and adolescents with normal BP.

scholarly journals Low body weight/thinness, overweight and obesity of children and adolescents from a Brazilian region of low economic status

2013 ◽  
Vol 31 (4) ◽  
pp. 437-443 ◽  
Author(s):  
Dartagnan Pinto Guedes ◽  
Francisléia Nascimento Almeida ◽  
Jaime Tolentino M. Neto ◽  
Maria de Fátima de M. Maia ◽  
Thatiana Maia Tolentino
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Task Force ◽  
Economic Status ◽  
Age Groups ◽  
Overweight And Obesity ◽  
The Body ◽  
Obesity Prevalence ◽  
Chi Square ◽  
Weight Excess

OBJECTIVE: To assess the prevalence of low body weight/thinness, overweight and obesity in a representative sample of children and adolescents from a Brazilian region with low economic development. METHODS: A total of 982 girls and 986 boys, aged seven to 17 years old and assisted by Segundo Tempo Program, from Montes Claros, Minas Gerais, Brazil, were included in the study. Low body weight/thinness, overweight and obesity were defined based on body mass cut-off indexes recommended by the International Obesity Task Force. The prevalence of the nutritional status according to sex and age was compared by chi-square test. RESULTS: In girls, the frequency of low body weight/thinness, overweight and obesity was 4.1, 18.4 and 3.8%, respectively; in boys, these percentages were 6.3, 13.2 and 2.9%, respectively. The low body weight/thinness for girls raised from 2.7% (7-10 years old) to 5.5% (15-17 years old); the body weight excess (overweight and obesity) decreased from 30.1 to 16.2% for the same age groups. In boys, the corresponding trends were from 3.2 to 9.4% for low body weight/thinness, and from 23.4 to 9.2%, for body weight excess. CONCLUSIONS: The data indicate that, even in a region with low economic status, the body weight excess was the main problem associated with nutritional health. The high overweight and obesity prevalence rates indicate the need of public policies for promoting healthy feeding behaviors and physical activity.

Long-term changes in body weight, BMI, and adiposity rebound among children and adolescents in the Czech republic

2007 ◽  
Vol 5 (3) ◽  
pp. 409-425 ◽  
Author(s):  
J. Vignerová ◽  
L. Humeníkova ◽  
M. Brabec ◽  
J. Riedlová ◽  
P. Bláha
Keyword(s):  
Body Weight ◽  
Czech Republic ◽  
Children And Adolescents ◽  
The Czech Republic ◽  
Adiposity Rebound ◽  
Long Term Changes
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