scholarly journals Radiation-induced pathomorphism of endemic goiter in children and adolescents in a focus of iodine deficiency (initial manifestations of remore effects of the Chernobyl accident)

1995 ◽  
Vol 41 (3) ◽  
pp. 17-23 ◽  
Author(s):  
E. P. Kasatkina ◽  
D. Ye. Shilin ◽  
A. N. Matkovskaya ◽  
K N. Sokolovskaya ◽  
T. N. Volkova ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Iodine Deficiency ◽  
Chernobyl Accident ◽  
Radiation Effects ◽  
Low Dose ◽  
Endemic Goiter ◽  
Morphological Characteristics ◽  
Increased Risk ◽  
Diffuse Goiter ◽  
Progressive Growth

The formation of remote consequences of radiation effects on the thyroid status of the population exposed to low-dose radiation was studied. The authors analyzed epidemiological, clinical, biochemical, hormonal, ultrasonographic, immunological, and morphological characteristics of the prevalence and intensity of endemic goiter in children and adolescents living in two iodine-deficient districts of the Oryol region observed after contamination of their territory with 137-Cs in a dose of 1 to 5 Ci/km2 and in-corporation of 131-I in a dose of 20-30 rad and in a control district free from radiation contamination. The results indicate that under the effect of low-dose combined irradiation endemic goiter in the observed districts acquired atypical features in the six years that passed since the Chernobyl accident in comparison with that in the control region: 1) thyromegalia prevalence is increased, its level being disproportionate with the degree of the existent iodine deficiency; 2) sex-specific differences are completely absent; 3) the maximal strain is observed in children exposed to radioactive iodine in utero 4) morphologically, variants of diffuse goiter with a high risk of node formation predominate; 5) progressive growth of thyroid parenchyma is associated with increased thyroglobulin elimination, this increasing the strain of the humoral component of antithyroid autoimmunity. These data indicate that the modifying effect of low-dose exposure on endemic goiter resulted in the disease pathomorphism associated with oncological risk and increased risk of autoimmune thyroiditis.

Iodine deficiency diseases in children and adolescents (plenary lecture)

2019 ◽  
Vol 43 (3) ◽  
pp. 3-7 ◽  
Author(s):  
E. P. Kasatkina
Keyword(s):  
Thyroid Gland ◽  
Adverse Effects ◽  
Children And Adolescents ◽  
Human Health ◽  
Iodine Deficiency ◽  
Functional Activity ◽  
Endemic Goiter ◽  
Plenary Lecture ◽  
Long Time ◽  
Deficiency Diseases

The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. It has now been proven that, in addition to goiter, iodine deficiency also has other adverse effects on human health. In 1983, the term "endemic goiter" was replaced by the term  "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency.

Impairment of neuromotor and cognitive development in iodine-deficient schoolchildren with normal physical growth

1993 ◽  
Vol 129 (6) ◽  
pp. 501-504 ◽  
Author(s):  
F Azizi ◽  
A Sarshar ◽  
M Nafarabadi ◽  
A Ghazi ◽  
M Kimiagar ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Children And Adolescents ◽  
Thyroid Function ◽  
Iodine Deficiency ◽  
Endemic Goiter ◽  
Physical Growth ◽  
Psychomotor Development ◽  
Somatic Development ◽  
Intellectual Quotient ◽  
The Mean

In order to detect somatic and psychomotor disturbances in children and adolescents residing in areas of iodine deficiency, schoolchildren from three areas with different degrees of iodine deficiency were studied. In Randan, the prevalence of severe endemic goiter was accompanied by alteration in thyroid function, increased thyrotropin levels and retardation of both bone and psychomotor age and decreased intellectual quotient. In Tehran, where iodine deficiency is mild, visible goiter was present in 1 5% of schoolchildren but no alterations in thyroid function, serum thyrotropin, somatic or psychomotor development could be detected. In Zagoon, where the prevalence and severity of goiter was less than Randan but more than Tehran, thyroid function was normal but slightly decreased as compared to Tehran; somatic development was unaltered, but retardation in psychomotor development was evident and the mean intellectual quotient was less than that of Tehranian schoolchildren. These findings indicate the occurrence of physical and psychomotor disturbances in apparently normal schoolchildren from areas of iodine deficiency. Alteration in psychomotor development may occur in children with normal physical growth, due to iodine deficiency.

Contraception and thrombophilia

2009 ◽  
Vol 29 (02) ◽  
pp. 193-196 ◽  
Author(s):  
H. Rott ◽  
A. Kruempel ◽  
G. Kappert ◽  
U. Nowak-Göttl ◽  
S. Halimeh
Keyword(s):  
Chronic Illness ◽  
High Risk ◽  
Children And Adolescents ◽  
Hormonal Contraception ◽  
Hormonal Contraceptives ◽  
Thromboembolic Events ◽  
Contraceptive Methods ◽  
Secondary Complications ◽  
Increased Risk ◽  
Coagulation Proteins

SummaryThe risk of thromboembolic events (TE) is increased by acquired or inherited thrombo -philias (IT). We know that some hormonal contraceptives also increase the risk of thrombosis, thus, the use of such contraceptives are discussed as contraindications in women with IT. TEs are infrequent events in children and adolescents and in the majority of cases are associated with secondary complications from underlying chronic illness. Although adolescents are not typically considered to be at high-risk for TE, this cohort is frequently using hormonal contraception, leading to an increased risk in cases with unknown IT. The risk of TE with pregnancy alone is higher than associated with combined hormonal contra -ception. Progestin-only methods have not been found to increase the risk of TE with only moderate changes of coagulation proteins compared to normal reference values. Conclusion: Thrombophilic women are good candidates for progestin-only contraceptive methods.

scholarly journals Free Sugars Consumption in Canada

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1471
Author(s):  
Huma Rana ◽  
Marie-Claude Mallet ◽  
Alejandro Gonzalez ◽  
Marie-France Verreault ◽  
Sylvie St-Pierre
Keyword(s):  
Type 2 Diabetes ◽  
Weight Gain ◽  
Total Energy ◽  
Children And Adolescents ◽  
Overweight And Obesity ◽  
Free Sugars ◽  
Added Sugars ◽  
Increased Risk ◽  
Baked Products

Free sugars (FS) are associated with a higher risk of dental decay in children and an increased risk of weight gain, overweight and obesity and type 2 diabetes. For this reason, Canada’s Food Guide recommends limiting foods and beverages that contribute to excess free sugars consumption. Estimating FS intakes is needed to inform policies and interventions aimed at reducing Canadians’ consumption of FS. The objective of this study was to estimate FS intake of Canadians using a new method that estimated the free sugars content of foods in the Canadian Nutrient File, the database used in national nutrition surveys. We define FS as sugars present in food products in which the structure has been broken down. We found that 12% of total energy (about 56 g) comes from FS in the diet of Canadians 1 year of age and older (≥1 year). The top four sources were: (1) sugars, syrups, preserves, confectionary, desserts; (2) soft drinks; (3) baked products and (4) juice (without added sugars), and accounted for 60% of total free sugars intake. The results show that efforts need to be sustained to help Canadians, particularly children and adolescents, to reduce their FS intake.

scholarly journals Perceived Social Status and Suicidal Ideation in Maltreated Children and Adolescents

2021 ◽  
Author(s):  
Kelli L. Dickerson ◽  
Helen M. Milojevich ◽  
Jodi A. Quas
Keyword(s):  
Risk Factor ◽  
Suicidal Ideation ◽  
Children And Adolescents ◽  
Social Status ◽  
Lower Risk ◽  
Developmental Patterns ◽  
Factors Associated ◽  
Established Risk Factor ◽  
Increased Risk ◽  
Perceived Social Status

AbstractRecent decades have seen an alarming increase in rates of suicide among young people, including children and adolescents (“youth”). Although child maltreatment constitutes a well-established risk factor for suicidal ideation in youth, few efforts have focused on identifying factors associated with maltreated youths’ increased risk for suicidal ideation, especially across development. The present study examined the relations between maltreated youths' (N = 279, M = 12.06 years, 52% female, 53% Latinx) perceptions of their social status and suicidal ideation and compared those relations between pre-adolescents and adolescents. Findings revealed unique developmental patterns: Perceived social status was associated with suicidal ideation, but only in adolescents, who showed greater risk for suicidal ideation if they viewed themselves as lower ranked in society and lower risk for suicidal ideation if they viewed themselves as higher ranked in society. Findings have implications for scientific and practical efforts aimed at better understanding and preventing suicide in a high-risk developmental population.

scholarly journals Congenital Malformations and Perinatal Deaths among the Children of Atomic Bomb Survivors: A Reappraisal

2021 ◽  
Author(s):  
Michiko Yamada ◽  
Kyoji Furukawa ◽  
Yoshimi Tatsukawa ◽  
Keiko Marumo ◽  
Sachiyo Funamoto ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Radiation Effects ◽  
Atomic Bomb ◽  
Perinatal Deaths ◽  
Neonatal Deaths ◽  
Atomic Bomb Survivors ◽  
Parental Exposure ◽  
Increased Risk ◽  
Major Congenital Malformations

Abstract From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes of children of atomic bomb survivors who had received radiation doses from zero to near-lethal levels. Past reports (1956, 1981, and 1990) on the cohort did not identify significant associations of radiation exposure with untoward pregnancy outcomes such as major congenital malformations, stillbirths, or neonatal deaths, individually or in aggregate. We have re-examined the risk of major congenital malformations and perinatal deaths in the children of the atomic bomb survivors (N=71,603) using fully reconstructed data to minimize the potential for bias, with refined estimates of the gonadal dose from the Dosimetry System 2002 and refined analytical methods for characterizing dose-response relationships. The analyses show that parental exposure is associated with increased risk for major congenital malformations and perinatal deaths, but the estimates are imprecise for direct radiation effects and most are not statistically significant. Nonetheless, the uniformly positive estimates for untoward pregnancy outcomes among children of both maternal and paternal survivors are useful for risk assessment purposes, although extending them to circumstances other than atomic bomb survivors comes with uncertainty as to the generalizability of the Hiroshima and Nagasaki populations.

scholarly journals Family violence against children in the wake of COVID-19 pandemic: a review of current perspectives and risk factors

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Noemí Pereda ◽  
Diego A. Díaz-Faes
Keyword(s):  
Children And Adolescents ◽  
Family Violence ◽  
Violence Against Children ◽  
The People ◽  
Increased Risk ◽  
Vulnerable Families ◽  
The Social ◽  
Restrictive Measures ◽  
Criminological Theories ◽  
The Impact

Abstract The situation of crisis produced by the Coronavirus (COVID-19) pandemic poses major challenges to societies all over the world. While efforts to contain the virus are vital to protect global health, these same efforts are exposing children and adolescents to an increased risk of family violence. Various criminological theories explain the causes of this new danger. The social isolation required by the measures taken in the different countries, the impact on jobs, the economic instability, high levels of tension and fear of the virus, and new forms of relationships have all increased levels of stress in the most vulnerable families and, therefore, the risk of violence. In addition, mandatory lockdowns imposed to curb the spread of the disease have trapped children in their homes, isolating them from the people and the resources that could help them. In general, the restrictive measures imposed in many countries have not been accompanied by an analysis of the access to the resources needed to reduce this risk. It is necessary to take urgent measures to intervene in these high-risk contexts so that children and adolescents can develop and prosper in a society which is likely to undergo profound changes, but in which the defense of their rights and protection must remain a major priority.

scholarly journals P125: Low dose intravenous ketorolac in renal colic, a pilot randomized controlled trial

CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S109-S110
Author(s):  
J. Chao ◽  
P. Brasher ◽  
K. Cheung ◽  
R. Sharma ◽  
K. Badke ◽  
...  
Keyword(s):  
Dose Group ◽  
Low Dose ◽  
Renal Colic ◽  
Standard Dose ◽  
Controlled Trial ◽  
Pain Reduction ◽  
Primary Objective ◽  
Recruitment Rate ◽  
Convenience Sample ◽  
Increased Risk

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are first-line analgesics for emergency department (ED) patients with renal colic. Lower doses of intravenous (IV) ketorolac may provide similar pain relief to standard dosing in patients with acute pain. Patients with renal colic may be at increased risk of acute kidney injury; exposing them to lower doses of NSAIDs may put them at lower risk while providing equally effective analgesia. We conducted a pilot study to determine the feasibility of a randomized trial comparing the effectiveness and safety of low with standard ketorolac dosing in ED patients with suspected renal colic. The primary objective was to demonstrate the ability to achieve an enrolment target of 2 patients per week. Methods: We enrolled a convenience sample of adults presenting to an academic urban ED with unilateral flank pain suspected to be renal colic. We randomized patients to 10 mg (low dose, intervention) or 30 mg (standard dose, control). Participants, treating physicians and nurses, and researchers were blinded to treatment allocation. Our main feasibility outcome was the recruitment rate. Secondary outcomes were changes in pain scores (0-10) at 30 and 120 minutes post-ketorolac administration, vital signs, adverse events and ED length of stay. Results: We approached 82 patients, of whom 47 (57.3%) were eligible. Of these, 36 consented to participating and 30 were randomized. The proportion of screened patients who were enrolled was 36.6% (30/82). We completed enrolment over a 21-week period, with an average recruitment rate of 1.5 patients/week (range 0-4). The average baseline pain score for all participants was 6.9 (SD = 2.1). At 30 minutes post-ketorolac administration, the low dose group had a mean pain reduction of 2.0 points compared to a pain reduction of 1.7 in standard dose group (difference = 0.3, 90% CI: -0.7 to 1.4). Conclusion: These preliminary results support the possibility that low dose ketorolac may be efficacious in this patient population. We did not meet our target recruitment of 2 patients per week as this was primarily due to restricted recruitment hours. To successfully conduct a larger trial, we would need to expand both recruitment hours and the number of sites.

Using a Temperature-Switching Approach to Evaluate Low-Dose-Rate Ionizing Radiation Effects on SET in Linear Bipolar Circuits

2019 ◽  
Vol 66 (7) ◽  
pp. 1557-1565 ◽  
Author(s):  
Shuai Yao ◽  
Wu Lu ◽  
Xin Yu ◽  
Qi Guo ◽  
Chengfa He ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Radiation Effects ◽  
Low Dose ◽  
Low Dose Rate
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