scholarly journals Endogenous hypercortisolism in the patient with obesity: the cause or a competing disorder

2016 ◽  
Vol 13 (1) ◽  
pp. 57-61
Author(s):  
Zhanna E. Belaya ◽  
Aleksandr V. Vorontsov ◽  
Aleksandr V. Il'in ◽  
Andrey Y. Grigor'ev ◽  
Lyudmila Y. Rozhinskaya
Keyword(s):  
Metabolic Syndrome ◽  
Weight Gain ◽  
Clinical Manifestations ◽  
Uncontrolled Hypertension ◽  
Adrenal Tumors ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Neurosurgical Treatment

Endogenous hypercortisolism (EH) is a rare endocrine disorder, one of the most frequent manifestations of which is obesity. Due to the high prevalence of the metabolic syndrome and the similarity of the clinical manifestations, EH may remain undiagnosed. However, prompt diagnosis and treatment can effectively promote complete cure of the patient. We describe the clinical case of a patient К., 58 years old, who suffered from morbid obesity, diabetes, uncontrolled hypertension and dyslipidemia. The CT examination revealed bilateral adrenal incidentalomas. The further follow-up let us to establish Cushing's disease. The adrenal tumors in this case may be the results of a long-term stimulation of the adrenal glands by ACTH. There is a possibility that the first manifestation of the disease began at the age of 30 years after the second pregnancy, when she observed weight gain and poorly controlled hypertension. When remission was achieved after neurosurgical treatment, we could observe significant improvements (reduction in body weight of 10 kg, improved glucose levels), but without the full normalization of all complications and symptoms.Conclusion: EH may cause the development of obesity and metabolic syndrome or significantly exacerbate its course. In cases of doubt, weight gain and poorly controlled manifestations of metabolic syndrome screening is justified to exclude EH.

The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis

2020 ◽  
pp. 48-56
Author(s):  
Vadim Dmitruk ◽  
Svetlana Khardikova ◽  
Marina Gerasimenko ◽  
Inna Evstigneeva ◽  
Tatiana Zaitseva
Keyword(s):  
Metabolic Syndrome ◽  
Psoriasis Vulgaris ◽  
Narrow Band ◽  
The Metabolic Syndrome ◽  
Pathological Conditions ◽  
Tnf Α ◽  
High Prevalence ◽  
Before And After ◽  
Ammatory Cytokine

Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.

scholarly journals Adolescent Metabolic Syndrome Risk Is Increased with Higher Infancy Weight Gain and Decreased with Longer Breast Feeding

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kim Khuc ◽  
Estela Blanco ◽  
Raquel Burrows ◽  
Marcela Reyes ◽  
Marcela Castillo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Gain ◽  
Current Knowledge ◽  
Age Groups ◽  
Sole Source ◽  
The Metabolic Syndrome ◽  
Early Infant ◽  
Increased Risk ◽  
Infant Weight Gain

Background. Prevalence of the metabolic syndrome is increasing in pediatric age groups worldwide. Meeting the criteria for the metabolic syndrome puts children at risk for later cardiovascular and metabolic disease.Methods. Using linear regression, we examined the association between infant weight gain from birth to 3 months and risk for the metabolic syndrome among 16- to 17-year-old Chilean adolescents (n=357), accounting for the extent of breastfeeding in infancy and known covariates including gender, birth weight, and socioeconomic status.Results. Participants were approximately half male (51%), born at 40 weeks of gestation weighing 3.5 kg, and 48% were exclusively breastfed for≥90days. Factors independently associated with increased risk of metabolic syndrome in adolescence were faster weight gain in the first 3 months of life (B=0.16,P<0.05) and male gender (B=0.24,P<0.05). Breastfeeding as the sole source of milk for≥90days was associated with significantly decreased risk of metabolic syndrome (B=−0.16).Conclusion. This study adds to current knowledge about early infant growth and breastfeeding and their long-term health effects.

scholarly journals The Effect of Long-Term Second-Generation Antipsychotics Use on the Metabolic Syndrome Parameters in Jordanian Population

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 320
Author(s):  
Abo Alrob ◽  
Alazzam ◽  
Alzoubi ◽  
Nusair ◽  
Amawi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Second Generation ◽  
Systolic Pressure ◽  
Clinical Information ◽  
P Value ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
Second Generation Antipsychotics ◽  
Continuous Use

Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs). Methods: In this retrospective study, we reviewed patients’ electronic medical records (EMRs) of all patients who received one SGA for at least six months, excluding patients who were taking other medications that are associated with significant effect on metabolic syndrome. Relevant clinical information was collected prior to starting the SGA and after six months of continuous use of the same SGA. Results: A total of 91 patients were included in the study. The majority of patients (72%) were diagnosed with schizophrenia. After six months of taking the SGA, 44% of patients experienced elevated systolic pressure, 54.9% had elevated triglyceride, and 31.9% had impaired glucose levels (p value < 0.05). Prior to initiating SGA therapy, 14.3% of patients had metabolic syndrome, while 37.4% had metabolic syndrome after six months of therapy, and it was more prominent in males compared to female patients (p value < 0.05). Conclusion: This study found a strong correlation between SGA use and the appearance of metabolic alterations, such as weight gain, glucose intolerance, and increased triglyceride levels. These findings highlight the importance of assessing metabolic deregulations to minimize SGA associated metabolic abnormalities.

High prevalence of the metabolic syndrome in hypertensive rural Chinese women

2008 ◽  
Vol 63 (5) ◽  
pp. 591-598 ◽  
Author(s):  
X. Zhang ◽  
Z. Sun ◽  
D. Zhang ◽  
L. Zheng ◽  
S. Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chinese Women ◽  
The Metabolic Syndrome ◽  
High Prevalence

scholarly journals The Prevalence and Predictors of Hypertension and the Metabolic Syndrome in Police Personnel

2021 ◽  
Vol 18 (13) ◽  
pp. 6728
Author(s):  
James D. Yates ◽  
Jeffrey W. F. Aldous ◽  
Daniel P. Bailey ◽  
Angel M. Chater ◽  
Andrew C. S. Mitchell ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Job Type ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Police Personnel ◽  
Behavioural Factors ◽  
Cardiometabolic Risk Markers ◽  
Police Forces

Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in ‘operational’ and ‘non-operational’ job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.

Prevalence of the metabolic syndrome in women with a previous diagnosis of polycystic ovary syndrome: long-term follow-up

2011 ◽  
Vol 96 (5) ◽  
pp. 1271-1274 ◽  
Author(s):  
Miriam Hudecova ◽  
Jan Holte ◽  
Matts Olovsson ◽  
Anders Larsson ◽  
Christian Berne ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
The Metabolic Syndrome ◽  
Previous Diagnosis ◽  
Long Term Follow Up

The metabolic syndrome in long-term cancer survivors, and important target for secondary preventive measures

2002 ◽  
Vol 28 (4) ◽  
pp. 195-214 ◽  
Author(s):  
Janine Nuver ◽  
Andries J Smit ◽  
Aleida Postma ◽  
Dirk Th Sleijfer ◽  
Jourik A Gietema
Keyword(s):  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Preventive Measures ◽  
The Metabolic Syndrome ◽  
Important Target

scholarly journals An Exploratory Analysis of Criteria for the Metabolic Syndrome and Its Prediction of Long-term Cardiovascular Outcomes

2005 ◽  
Vol 162 (5) ◽  
pp. 438-447 ◽  
Author(s):  
Cynthia J. Girman ◽  
Jacqueline M. Dekker ◽  
Thomas Rhodes ◽  
Giel Nijpels ◽  
Coen D. A. Stehouwer ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Outcomes ◽  
Exploratory Analysis ◽  
The Metabolic Syndrome
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