scholarly journals Obesity and reproductive function of women: epigenetic and somato-psychological features

2019 ◽  
Vol 16 (2) ◽  
pp. 9-15
Author(s):  
Elena N. Andreeva ◽  
Yulia S. Absatarova ◽  
Ekaterina V. Sheremetyeva ◽  
Valentina A. Fursenko
Keyword(s):  
Maternal Obesity ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Folic Acid Deficiency ◽  
Female Reproductive System ◽  
Cardiovascular Risks ◽  
Ovary Syndrome ◽  
Acid Deficiency ◽  
Psychological Features ◽  
Overweight Or Obesity

The review article presents data on the effects of obesity on the female reproductive system and offspring of mothers with overweight or obesity, such as infertility, miscarriages, premature birth, stillbirth, congenital anomalies and prematurity, as well as a high risk of cesarean section. Obesity accompanies polycystic ovary syndrome, worsening the metabolic profile and increasing the risk of developing depression and eating disorders. Maternal obesity and hyperglycemia are able to influence the formation of the fetus by epigenetic mechanisms without affecting the nucleotide sequences. Subsequently, the metabolic and cardiovascular risks increase in the descendants of obese or overweight mothers and gestational diabetes. Patients with obesity are characterized by a folic acid deficiency and a deficiency of the luteal phase. Exogenous administration of these substances improves pregnancy outcomes and prevents congenital malformations.

scholarly journals Polycystic ovary syndrome: clinical and pathogenetic aspects of a multidisciplinary problem

2021 ◽  
Vol 2 ◽  
pp. 7-14
Author(s):  
V.G. Syusyuka ◽  
M.Y. Sergienko ◽  
G.I. Makurina ◽  
O.A. Yershova ◽  
A.S. Chornenka
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Disorders ◽  
Polycystic Ovary ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Point Of View ◽  
The Body ◽  
Cardiovascular Risks ◽  
Ovary Syndrome ◽  
The Impact

The article presents data from guidelines, consensus and literature sources on the modern point of view regarding to the pathogenesis, diagnosis and principles of treatment of women with polycystic ovary syndrome. It is a systemic pathology that occurs in women of any age, from puberty to menopause, involving almost all systems of the body in the process. The work focuses on the variability of the clinical manifestations of this syndrome, which is characterized by menstrual irregularities, infertility, polycystic changes in the ovaries according to ultrasound, dermatopathies and metabolic disorders. The main purpose of diagnosing the syndrome is to determine the severity of clinical manifestations, the sources and pathogenesis of androgen hyperproduction, the impact on reproductive function, as well as the assessment of metabolic and cardiovascular risks. Given the multifaceted clinical manifestations, the management of women with polycystic ovary syndrome requires a multidisciplinary approach, and pathogenetic therapy should include normalization of the hormonal profile and menstrual function, treatment of dermatopathies, correction of metabolic disorders, treatment of infertility (if pregnancy is relevant), etc.

Endocan as a novel biomarker to evaluate cardiovascular risks in Polycystic Ovary Syndrome

2016 ◽  
Author(s):  
Mahmut Apaydin ◽  
Selvihan Beysel ◽  
Mustafa Caliskan ◽  
Muhammed Kizilgul ◽  
Ozgur Ozcelik ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cardiovascular Risks ◽  
Ovary Syndrome

scholarly journals Menstrual and reproductive function repair in patients with polycystic ovary syndrome and obesity by correcting of glucose intolerance

2008 ◽  
Vol 5 (2) ◽  
pp. 38-41 ◽  
Author(s):  
O I Lineva ◽  
M V Glukhova
Keyword(s):  
Reproductive System ◽  
Negative Impact ◽  
Positive Impact ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Endocrine Function ◽  
Anthropometric Parameters ◽  
Ovary Syndrome ◽  
High Incidence ◽  
Total Treatment

The aim of the study was to investigate the effect of sibutramine on metabolic and hormonal parameters in women with PCOS and obesity. Materials and methods. The study included 53 women aged 18 to 35 years (mean age 31,3 ± 1,1 years) with PCOS and obesity. All patients received therapy with sibutramine. The total treatment duration was 6 months. The treatment was evaluated monthly nature of the menstrual cycle, anthropometric parameters (body weight, BMI, ON, ON, ON / OF). The Results. The studies found that after 3 months of treatment with weight loss was 8,1 ± 0,31 kg, after 6 months - 13,1 ± 0,78 kg (p 0,05). Results of the survey of women included in this study strongly support the negative impact of obesity on the functional state of the reproductive system, evidenced by the high incidence of anovulation, rhythm disturbances of menstruation (amenorrhea up to), infertility. Conclusions. The obtained results once again confirm the high efficacy and safety of sibutramine to reduce body mass, suggest correction of metabolic, hormonal disorders and positive impact on women's reproductive health. This allows us to consider the use of sibutramine in women with PCOS and obesity as a way to restore the endocrine function of the reproductive system.

scholarly journals Inflammation and reproductive function in women with polycystic ovary syndrome

2021 ◽  
Author(s):  
Leandro M Velez ◽  
Marcus Seldin ◽  
Alicia B Motta
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chronic Inflammation ◽  
Polycystic Ovary ◽  
Essential Feature ◽  
Reproductive Function ◽  
Cardiovascular Complications ◽  
Reproductive Age ◽  
Metabolic Abnormalities ◽  
Ovary Syndrome ◽  
Inflammatory State

Abstract Polycystic Ovary Syndrome (PCOS) is one of the most frequent endocrinopathies, affecting 5–10% of women of reproductive age, and is characterized by the presence of ovarian cysts, oligo, or anovulation, and clinical or biochemical hyperandrogenism [1]. Metabolic abnormalities such as hyperinsulinemia, insulin resistance, cardiovascular complications, dyslipidemia, and obesity are frequently present in PCOS women [1]. Several key pathogenic pathways overlap between these metabolic abnormalities, notably chronic inflammation. The observation that this mechanism was shared led to the hypothesis that a chronic inflammatory state could contribute to the pathogenesis of PCOS [2]. Moreover, while physiological inflammation is an essential feature of reproductive events such as ovulation, menstruation, implantation, and labour at term [3], the establishment of chronic inflammation may be a pivotal feature of the observed reproductive dysfunctions in PCOS women [2]. Taken together, the present work aims to review the available evidence about inflammatory mediators and related mechanisms in women with PCOS, with an emphasis on reproductive function.

scholarly journals Pregnancy-related outcomes for women with polycystic ovary syndrome

2017 ◽  
Vol 13 (3) ◽  
pp. 89-97 ◽  
Author(s):  
Rose McDonnell ◽  
Roger J Hart
Keyword(s):  
Health Care ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Congenital Anomalies ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Short Term ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Hypertensive Disorders

The polycystic ovary syndrome is a common endocrine disorder that has profound implications for women throughout their reproductive years. A diagnosis of polycystic ovary syndrome is associated with reproductive challenges including a difficulty in conceiving as well as the pregnancy-related complications of miscarriage, hypertensive disorders, gestational diabetes and prematurity. Consequently, polycystic ovary syndrome has profound implications for women and their offspring with regard to reproductive function in the short term and in the longer term the risk of chronic illness and congenital anomalies, and health care resources should be directed accordingly to mitigate against these risks.

scholarly journals Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

2019 ◽  
Vol 7 (8) ◽  
pp. 86 ◽  
Author(s):  
Elisabet Stener-Victorin ◽  
Maria Manti ◽  
Romina Fornes ◽  
Sanjiv Risal ◽  
Haojiang Lu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Anxiety Disorders ◽  
Maternal Obesity ◽  
Steroid Receptors ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Psychological Traits ◽  
Androgen Exposure ◽  
Prenatal Androgen Exposure ◽  
Prenatal Androgen

Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring’s susceptibility to develop psychiatric ill-health will be discussed.

scholarly journals Exercise and reproductive function in polycystic ovary syndrome: protocol of a systematic review

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Isis Kelly dos Santos ◽  
Romilson de Lima Nunes ◽  
Gustavo Mafaldo Soares ◽  
Tecia Maria de Oliveira Maranhão ◽  
Paulo Moreira Silva Dantas
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Ovary Syndrome

Effect of metformin on the reproductive function of women with different phenotypes of polycystic ovary syndrome

2017 ◽  
Vol 10_2017 ◽  
pp. 55-61 ◽  
Author(s):  
Naidukova A.A. Naidukova ◽  
Ananyev E.V. Ananyev ◽  
Chernukha G.E. Chernukha ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Ovary Syndrome

scholarly journals Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10245
Author(s):  
Xueying Wang ◽  
Xiaofei Liu ◽  
Zifan Song ◽  
Xin Shen ◽  
Siying Lu ◽  
...  
Keyword(s):  
Reproductive System ◽  
Polycystic Ovary ◽  
Reproductive Organs ◽  
Diagnostic Biomarker ◽  
Female Reproductive System ◽  
Ovary Syndrome ◽  
Body Distribution ◽  
Common Receptor ◽  
Extensive Body ◽  
Intracellular Cascades

APLN, APELA and their common receptor APLNR (composing the apelinergic axis) have been described in various species with extensive body distribution and multiple physiological functions. Recent studies have witnessed emerging intracellular cascades triggered by APLN and APELA which play crucial roles in female reproductive organs, including hypothalamus-pituitary-gonadal axis, ovary, oviduct, uterus and placenta. However, a comprehensive summary of APLN and APELA roles in physiology and pathology of female reproductive system has not been reported to date. In this review, we aim to concentrate on the general characteristics of APLN and APELA, as well as their specific physiological roles in female reproductive system. Meanwhile, the pathological contexts of apelinergic axis dysregulation in the obstetrics and gynecology are also summarized here, suggesting its potential prospect as a diagnostic biomarker and/or therapeutic intervention in the polycystic ovary syndrome, ovarian cancer, preeclampsia and gestational diabetes mellitus.

Discussion of new approach to the management of polycystic ovary syndrome

2017 ◽  
pp. 45-48
Author(s):  
Z.M. Doubossarskaya ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Critical Evaluation ◽  
Life Quality ◽  
Reproductive Function ◽  
Ovary Syndrome ◽  
Therapy Program ◽  
Life Style Changes ◽  
Complex Therapy

The objective: Critical evaluation of modern therapeutic methods for polycystic ovary syndrome (POS); depending of reproductive plans for infertility therapy needed or removing of cosmetic issues by including Protalis to complex therapy program. Patients and methods. 40 women in the age from 27 to 37; with confirmed diagnosis of POS according to criteria of Rotterdam consensus were examined. They were divided to 2 subgroups; first (30) got traditional therapy with individual variations: laparoscopic drilling of ovaries, Metphormin, lifestyle modification and Protalis. Second group got their therapy without Protalis. Every 3, 6, 9, 12 months clinical, hormonal manifestations of POS were controlled. Results. Usage of complex therapy of POS with Protalis facilitated statistically unreliable lowering of BMI; but number of women with irregular menstrual periods increased in 3.4 times; restoration of reproductive function were happened in 26.6 % cases (10% without Protalis). This therapy facilitated diminishing of cosmetic issues, better skin conditions. Diminishing of acne, lowering of hirsute number and with complex approach to reproductive health they got better life quality. Conclusions. Practicing gynecologists after the studies of several etiological hypotheses about POS, realized that syndrome is a defect of not only one gene but it is polygenic and it is explain phenotype of patients and all variations depending of a type of metabolic disorders. Life style changes (diet and exercises) are cornerstone of management of patients with POS with high body mass and obesity (particularly abdominal) and they can lower many symptoms of POS? considering effectiveness of usage of Protalis in the complex therapy of POS in our study and in documented foreign studies it can be recommended in usage in clinical practice. Key words: polycystic ovary syndrome, chronic anovulation, hyperandrogeny, Protalis.

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