scholarly journals Spontaneous and induced secretion of the pro-inflammatory and anti-inflammatory cytokines in patients with type 2 diabetes mellitus and diabetic foot syndrome

2020 ◽  
Vol 23 (3) ◽  
pp. 210-222
Author(s):  
E. V. Shikh ◽  
N. A. Petunina ◽  
L. V. Nedosugova ◽  
K. O. Galstyan ◽  
K. I. Kolmychkova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome ◽  
Control Group ◽  
Metabolic Drug ◽  
Anti Inflammatory

AIMS:Investigation of spontaneous and induced secretion of the pro-inflammatory cytokine tumor necrosis factor- (TNF-) and the anti-inflammatory chemokine C-C Motif Chemokine Ligand 18 (CCL18) by monocytes isolated from blood of patients with long-term type 2 diabetes mellitus (T2DM), both with or without foot ulcers and the effect of the course use of the combined metabolic drug Kokarnit as part of complex therapy on the dynamics of the severity of symptoms of DSPN and the cytokine phenotype in patients with long-term non-healing ulcers of the lower extremities MATERIALS AND METHODS:121 patients with T2DM, 79 without diabetic foot syndrome (DFS) and 42 patients with DFS were included. CD14+ monocytes were isolated from patients blood and stimulated by interferon- (IFN-) and interleukine-4 (IL-4) for induction of pro- and anti-inflammatory monocyte activation, respectively. The concentrations of TNF- and CCL18 in the culture medium were measured using ELISA on day 1 and day 6 after cell stimulation in all patients before taking the combined metabolic drug Kokarnit. Then they were randomly allocated either to the control group (57 people), to whom Kokarnit was added to standard treatment, or to the comparison group. After a 9-day course of application of Kokarnit, the dynamics of indicators was evaluated on a TSS scale. Assessment of cytokine status was carried out in 18 people with long-term non-healing ulcerative defects of the lower extremities, on the first and ninth day of treatment. RESULTS:A correlation was found between HbA1cand levels of stimulated secretion of TNF (r=0.726, p=0.027), CCL18 (r=-0.949, p=0.051) in patients with DSPN. In all patients with different duration of VDS, an increase in secretion of TNF- and CCL18 was observed (p0.05). However, stimulation of anti-inflammatory activation was not observed in patients with ulcerative defects lasting more than 6 months (p=0.033). The use of cocarnit in these patients had a decrease in stimulated secretion of TNF and an increase in CCL18. Throughout the entire observation period with the therapy, the score for the symptoms of polyneuropathy on the TSS scale in patients of the control group was statistically significantly higher. CONCLUSION:Against the background of therapy in patients of the main group, a statistically significant dynamics of indicators on the TSS scale was established. The cytokine modulating ability of Kokarnit to switch the cytokine status into the category of anti-inflammatory.

scholarly journals THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS

2019 ◽  
pp. 551-553
Author(s):  
DHARMA LINDARTO ◽  
YETTY MACHRINA ◽  
SANTI SYAFRIL ◽  
AWALUDDIN SARAGIH
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Treatment Group ◽  
Control Group ◽  
Model Assessment ◽  
Anti Inflammatory

Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs). Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period. Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05). Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

scholarly journals Interleukins As a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus

2019 ◽  
Vol 7 (1) ◽  
pp. 1-7
Author(s):  
Süleyman KALELİ ◽  
Ceyhun VARIM ◽  
Ahmet NALBANT ◽  
Hayrullah YAZAR ◽  
Mehmet AKDOĞAN
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome

scholarly journals Communication Of Quality Of Life Indicators, Functional Methods Of Research And Neuromarker BNDF In Patients With Diabetes Mellitus 2 With Diabetic Foot Syndrome

2021 ◽  
Vol 03 (05) ◽  
pp. 12-23
Author(s):  
Alimkhanov Olimkhon Omilkhonovich ◽  
◽  
Kamalov Telman Tulyaganovich ◽  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetic Foot ◽  
Neuromuscular Transmission ◽  
Glycated Haemoglobin ◽  
Diabetic Foot Syndrome ◽  
Control Group

The purpose of the study is to study the correlation rate of the quality of life, electroneuromyography, doppler and neuro markers BNDF in the blood in patients with a type 2 of type with diabetic foot syndrome. Methods: The following 2 groups of patients were formed: 1 gr. - SDS patients, neuropathic form -37 patients, 2 gr. - SDS patients, neuroichmic form -35 patients, 3 gr. - Control group, these are 20 healthy persons of the appropriate age and gender. Results: In all groups of patients, the quality of life is significantly different in the FSHC questionnaire compared with the control group (p <0.05). In patients with a neuroecemic form of diabetic foot syndrome, a significant decrease was found (p <0.05). All indicators of doppler song vessels of legs compared with patients with neuropathic shape. Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia of an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the lower leg, is discovered. The definition of neuromuscular transmission showed that the patients of the 1st and 2nd groups have a weak reduction in muscle contraction involuntarily. This confirmed the impairment of neuromuscular transmission in both groups. Conclusions: 1) A questionnaire to determine the quality indicators - FSHK is the most sensitive and informative to determine the quality of life in patients with type 2 diabetes mellitus with neuropathic and neuroecemic forms 2) FSHP questionnaire can be used for dynamic assessment of type 2 diabetes patients with neuropathic and neuroecemic forms in outpatient clinical practice. 3) Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia on an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the shin, M-answer when stimulating a tibial nerve.

scholarly journals POTENTIAL HOLISTIC PREVENTIVE AND THERAPEUTIC EFFECTS OF GARCINIA MANGOSTANA EXTRACT OR ISOLATES IN TYPE 2 DIABETES MELLITUS: A REVIEW

2019 ◽  
pp. 7-11
Author(s):  
JOANNA ERIN HANRAHAN ◽  
PRISCILLA AYA MAHESWARI SUBROTO ◽  
RAHARDI PRASETIA PRIAWAN ◽  
DESAK GEDE BUDI KRISNAMURTI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treated Group ◽  
Control Group ◽  
Therapeutic Effects ◽  
Garcinia Mangostana ◽  
Long Term Outcome

Objective: The need for long-term medication in diabetes mellitus has led to a search for herbal medicines as alternative treatments. Several studies have shown that extract or isolates of Garcinia mangostana can help prevent and treat type 2 diabetes mellitus (T2DM). Methods: This review was conducted by searching various databases, including PubMed, ClinicalKey, ScienceDirect, and EBSCOhost. We analyzed papers published within the previous 10 y. Results: All in vitro, in vivo, and clinical studies that evaluated the pharmacological effects of extract or isolates of G. mangostana in T2DM were reviewed. G. mangostana was found to suppress adipogenesis and regulate lipid homeostasis, thus improving lipid profiles and preventing T2DM. G. mangostana also demonstrated hypoglycemic properties, including the ability to decrease fasting blood glucose and mildly increase pancreatic β-cell numbers and activity. The mangosteen-treated group in one study showed a decrease in Homeostatic Model Assesment for Insulin Resistance (HOMA-IR), indicating improved insulin sensitivity, along with a significant decrease in the high-sensitivity CRP (hs-CRP) levels. Histopathology showed that the α-mangostin-treated group had less damage to pancreatic β cells, healthier hepatocytes and central veins, and less glomerular and tubular epithelial necrosis than the diabetic control group. Moreover, the antioxidant effect of G. mangostana was shown to protect against the micro-and macrovascular damage caused by T2DM. Conclusion: Extract or isolates of G. mangostana possess strong potential to prevent and treat T2DM. Further research evaluating long-term outcome biomarkers in humans is needed to confirm the drug’s glycemic control capacity.

Interleukins as a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus

2018 ◽  
Author(s):  
Suleyman KALELI ◽  
◽  
Ceyhun VARIM ◽  
Ahmet NALBANT ◽  
Hayrullah YAZAR ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome

scholarly journals Pengaruh Senam Kaki terhadap Nilai Ankle Brachial Index Pada Pasien Diebetes Melitus Tipe II: Sebuah Tinjauan Sistematis

2021 ◽  
Vol 21 (2) ◽  
pp. 657
Author(s):  
Yofa Anggriani Utama ◽  
Sutrisari Sabrina Nainggolan
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Research Design ◽  
Diabetic Foot ◽  
Ankle Brachial Index ◽  
Good Effect ◽  
Control Group

Diabetes mellitus is a chronic disease that occurs due to metabolic disorders characterized by blood sugar levels that exceed normal limits. Diabetic foot is a complication of diabetes mellitus that can cause ulcers, infection, gangrene and charcot's atrophy. Diabetic foot exercise is one of the interventions that can overcome peripheral circulation problems that occur in type 2 diabetes mellitus patients.The purpose of this study is to identify the effect of diabetic foot exercise on the value of the ankle brachial index in Type II Diabetes Mellitus patients through a systematic review. The research design included in this systematic review uses a research design that is a quantitative method with a systematic review approach. The first article shows that the treatment group experienced an increase in mean and the control group experienced a decrease in the mean. The physical activity of the respondents affected the ABI value just before the ABI examination was carried out, and it was also influenced by cholesterol which the researchers did not control for all respondents. So it can be concluded that the diabetes foot exercise intervention has an effect in increasing blood circulation to the feet. The second article shows that when compared to the results of the ABI values for the two groups there are significant results, so that diabetic foot exercises can be given four times a week for one month, providing good benefits in increasing blood pressure in the legs. The results of this systematic review indicate that foot exercise has a good effect on ankle brachial index in type 2 diabetes mellitus patients who have problems with peripheral perfusion. If this intervention is given as often as possible, it will have a good effect on the range of motion of the joints so that it can improve the quality of life of patients with type 2 diabetes mellitus.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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