Interleukins as a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus

2018 ◽  
Author(s):  
Suleyman KALELI ◽  
◽  
Ceyhun VARIM ◽  
Ahmet NALBANT ◽  
Hayrullah YAZAR ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome

scholarly journals Interleukins As a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus

2019 ◽  
Vol 7 (1) ◽  
pp. 1-7
Author(s):  
Süleyman KALELİ ◽  
Ceyhun VARIM ◽  
Ahmet NALBANT ◽  
Hayrullah YAZAR ◽  
Mehmet AKDOĞAN
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome

scholarly journals Spontaneous and induced secretion of the pro-inflammatory and anti-inflammatory cytokines in patients with type 2 diabetes mellitus and diabetic foot syndrome

2020 ◽  
Vol 23 (3) ◽  
pp. 210-222
Author(s):  
E. V. Shikh ◽  
N. A. Petunina ◽  
L. V. Nedosugova ◽  
K. O. Galstyan ◽  
K. I. Kolmychkova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome ◽  
Control Group ◽  
Metabolic Drug ◽  
Anti Inflammatory

AIMS:Investigation of spontaneous and induced secretion of the pro-inflammatory cytokine tumor necrosis factor- (TNF-) and the anti-inflammatory chemokine C-C Motif Chemokine Ligand 18 (CCL18) by monocytes isolated from blood of patients with long-term type 2 diabetes mellitus (T2DM), both with or without foot ulcers and the effect of the course use of the combined metabolic drug Kokarnit as part of complex therapy on the dynamics of the severity of symptoms of DSPN and the cytokine phenotype in patients with long-term non-healing ulcers of the lower extremities MATERIALS AND METHODS:121 patients with T2DM, 79 without diabetic foot syndrome (DFS) and 42 patients with DFS were included. CD14+ monocytes were isolated from patients blood and stimulated by interferon- (IFN-) and interleukine-4 (IL-4) for induction of pro- and anti-inflammatory monocyte activation, respectively. The concentrations of TNF- and CCL18 in the culture medium were measured using ELISA on day 1 and day 6 after cell stimulation in all patients before taking the combined metabolic drug Kokarnit. Then they were randomly allocated either to the control group (57 people), to whom Kokarnit was added to standard treatment, or to the comparison group. After a 9-day course of application of Kokarnit, the dynamics of indicators was evaluated on a TSS scale. Assessment of cytokine status was carried out in 18 people with long-term non-healing ulcerative defects of the lower extremities, on the first and ninth day of treatment. RESULTS:A correlation was found between HbA1cand levels of stimulated secretion of TNF (r=0.726, p=0.027), CCL18 (r=-0.949, p=0.051) in patients with DSPN. In all patients with different duration of VDS, an increase in secretion of TNF- and CCL18 was observed (p0.05). However, stimulation of anti-inflammatory activation was not observed in patients with ulcerative defects lasting more than 6 months (p=0.033). The use of cocarnit in these patients had a decrease in stimulated secretion of TNF and an increase in CCL18. Throughout the entire observation period with the therapy, the score for the symptoms of polyneuropathy on the TSS scale in patients of the control group was statistically significantly higher. CONCLUSION:Against the background of therapy in patients of the main group, a statistically significant dynamics of indicators on the TSS scale was established. The cytokine modulating ability of Kokarnit to switch the cytokine status into the category of anti-inflammatory.

scholarly journals Diabetic Foot Ulcers and Risk Fall in People with Type 2 Diabetes Mellitus in BLUD RSUD Dr. Ben Mboi Manggarai Regency, NTT

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Oliva Suyen Ningsih ◽  
Kornelia Romana Iwa ◽  
Maria Getrida Simon ◽  
Kataria Anastasia Sinar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
P Value ◽  
Diabetic Foot Ulcers ◽  
Risk Of Falling ◽  
Risk Of Falls

The prevalence of diabetes mellitus in Manggarai Regency in 2019 is 535 people and some of them have diabetic foot ulcers. Patients with diabetic foot ulcers had a higher risk of falling than others.This study was to determine the risk factors for diabetic foot ulcers and the risk of falls in patients with type 2 diabetes mellitus. A quantitative study using a cross-sectional study was conducted at BLUD RSUD dr. Ben Mboi  in April-June 2020 (n = 51).The sampling technique used was purposive sampling with a questionnaire of diabetic foot screening and risk stratification form and Morse scale. Logistic regression results showed that there was a significant relationship between claudication (AOR: 8.409, 95% CI 1.664-42.500, p value 0.010), history of previous diabetic foot ulcers (AOR: 5,680, 95% CI 1,151-28,035, p value 0.033) with diabetic foot ulcers. There was a significant relationship between hypertension (AOR: 0.152, 95% CI 0.028-0.834, p value 0.030), diabetic foot ulcers (AOR: 11.392, 95% CI 1.277-101.651, p value 0.029) with the risk of falling for patients with type 2 diabetes mellitus.  Assessment of the risk of diabetic foot ulcers and the risk of falls should be done in patients with diabetes mellitus with or without neuropathy peripheral

scholarly journals Prevalence and Associated Factors of Diabetic Foot at Risk among Type 2 Diabetes Mellitus Patients Attending Primary Health Clinics in Kuantan

2020 ◽  
Vol 19 (3) ◽  
Author(s):  
NH Azmi ◽  
A Abdul Hadi ◽  
MA Md Aris ◽  
HE Nasreen ◽  
A Che-Ahmad
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
At Risk ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Associated Factors ◽  
Care Practice ◽  
Health Clinics ◽  
Primary Health

Introduction: The diabetic foot at risk is the diabetic foot which is at risk of ulceration, hence the importance of identifying the foot at this stage. This study aims to assess the prevalence of diabetic foot at risk and its associated factors among type 2 diabetes mellitus patients’ attending primary health clinics in Kuantan. Methods and methods : This was a cross-sectional study conducted at four primary health clinics in Kuantan involving 450 study participants who were selected by using universal sampling method. Foot examination was carried out and foot at risk was classified based on the Kings’ Classification. Multiple logistic regressions were performed to identify the predictors for diabetic foot at risk. Results: The prevalence of diabetic foot at risk was 31.3%. Multivariate logistic regression analysis identified age (OR 1.04, 95% CI: 1.01-1.06), smoker (OR 4.11, 95% CI: 1.96-8.63) and duration of diabetes more than 10 years (OR1.77, 95% CI: 1.05-2.98) as risk factors for diabetic foot at risk. Respondents with higher diabetic foot practice score (OR 0.87, 95% CI: 0.77-0.98) have lesser risk of developing diabetic foot at risk. Conclusion: Patients who are older, smoker and/or have chronic diabetes are predicted to be at higher risk to develop the diabetic foot at risk. This study also showed that patients with better foot care practice has lesser risk. Therefore, these are the groups of patients that need to be targeted for early detection and intervention to prevent serious complications.

scholarly journals Hubungan Perilaku Perawatan Kaki dengan Terjadinya Komplikasi Luka Kaki Diabetes pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Tuntungan Kota Medan

2018 ◽  
Vol 1 (1) ◽  
pp. 124-131
Author(s):  
Rina Amelia
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Center ◽  
Diabetic Foot ◽  
Foot Care ◽  
Chi Square ◽  
Public Health Center

Diabetes merupakan peyakit kronis yang disebabkan karena kekurangan atau tidak efektifnya insulin yang dihasilkan. WHO memperkirakan jumlah penduduk dunia yang menderita diabetes pada tahun 2030 akan meningkat paling sedikit menjadi 366 juta. Indonesia menempati urutan keempat terbanyak dengan prevalensi 8,6% dari seluruh penduduk. Diabetes akan menjadi masalah yang serius apabila telah terjadi komplikasi, salah satu komplikasi adalah luka kaki diabetes (diabetic foot). Komplikasi luka kaki diabetes menjadi penyebab lamanya hospitalisasi dan amputasi lebih dari 90% ekstremitas bawah pada penderita diabetes. Tujuan penelitian adalah untuk menganalisis hubungan perilakuperawatan kaki dengan terjadinya komplikasi luka kaki diabetes pada pasienDM tipe 2di Puskesmas Tuntungan Medan. Disain penelitian adalah analitik dengan pendekatan cross sectional. Populasi penelitian adalah seluruh penderita DM tipe 2 yang datang ke Puskesmas Tuntungan Medan dengan sampel sebanyak 83 orang (consecutive sampling). Instrumen penilaian perilaku perawatan kaki yang digunakan adalah Questions determining the knowledge and practice about foot careyang terdiri dari 15 item pertanyaan. Analisis data menggunakan uji statistik chi square. Hasil penelitian menunjukkansebanyak 48 orang pasien diabetes (57,8%) memiliki perilaku yang buruk terhadap perawatan kaki, sebanyak 29 orang (349%) mempunyai riwayat komplikasi luka kaki dibetes (ulkus). Hasil analisis chi square menunjukkan terdapat hubungan antara perilaku perawatan kaki diabetes dengan kejadian komplikasi luka kaki diabetes pada pasien DM tipe 2 di Puskesmas Tuntungan Medan (p<0.05). Perilaku perawatan kaki sangat berperan terhadap terjadinya luka kaki diabetes. Untuk membentuk perilaku yang baik dibutuhkan edukasi oleh dokter maupun oleh petugas kesehatan kepada pasien diabetes. Diabetes is a chronic disease caused by lack or ineffectiveness of insulin. WHO estimates that the world population with diabetes in 2030 will increase to at least 366 million people. Indonesia is the world’s fourth most populated country and its prevalence of diabetes is 8.6% of the entire population. Diabetes will be a serious problem once complications occurrs. One of the complications is diabetic foot.  diabetic foot  caused a longer length of hospital stay and more than 90% leads to the amputation of the lower limb . The objective of this study was to analyze the relationship between diabetic foot care behaviors and the diabetic foot complications in patients with type 2 diabetes mellitus at Tuntungan Public Health Center in Medan. This study employed an analytic study  with cross sectional approach. The population of this study was all patients with type 2 diabetes mellitus who came to Tuntungan Public Health Center in Medan  and 83 patients were recruited as samples (consecutive sampling). The research used a questionnaires with 15 questions   to collect data of knowledge and foot care behaviour. Data were analyzed using chi square test. The results showed that 48 diabetic patients (57.8%) demonstrated poor behavior towards foot care, 29 patients (349%) had a history of diabetic foot ulcer complications. The results of the chi square analysis showed that there was a significant relationship between diabetic foot care behavior and diabetic foot complications in patients with type 2 Diabetes Mellitus at Tuntungan Public Health Center in Medan (p <0.05). It was concluded that foot care behavior had a high correlation with the incidence of diabetic foot. It is recommended that doctors and health staffs educate diabetic patients to perform good foot care behaviors.

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