scholarly journals Age-Related Gray and White Matter Changes in Normal Adult Brains

2017 ◽  
Vol 8 (6) ◽  
pp. 899 ◽  
Author(s):  
Farnaz Farokhian ◽  
Chunlan Yang ◽  
Iman Beheshti ◽  
Hiroshi Matsuda ◽  
Shuicai Wu
Keyword(s):  
White Matter ◽  
Normal Adult ◽  
White Matter Changes ◽  
Age Related

Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease

2018 ◽  
Vol 15 (14) ◽  
pp. 1354-1360 ◽  
Author(s):  
Ping-Song Chou ◽  
Yi-Hui Kao ◽  
Meng-Ni Wu ◽  
Mei-Chuan Chou ◽  
Chun-Hung Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer Disease ◽  
Rating Scale ◽  
Vital Role ◽  
Independent Effect ◽  
Cerebral White Matter ◽  
Clinical Dementia Rating ◽  
White Matter Changes ◽  
Age Related ◽  
The Mean

Background: Cerebrovascular pathologies and hypertension could play a vital role in Alzheimer disease (AD) progression. However, whether cerebrovascular pathologies and hypertension accelerate the AD progression through an independent or interaction effect is unknown. Objective: To investigate the effect of the interactions of cerebrovascular pathologies and hypertension on AD progression. Method: A retrospective longitudinal study was conducted to compare AD courses in patients with different severities of cerebral White Matter Changes (WMCs) in relation to hypertension. Annual comprehensive psychometrics were performed. WMCs were rated using a rating scale for Age-related WMCs (ARWMC). Results: In total, 278 patients with sporadic AD were enrolled in this study. The mean age of the patients was 76.6 ± 7.4 years, and 166 patients had hypertension. Among AD patients with hypertension, those with deterioration in clinical dementia rating-sum of box (CDR-SB) and CDR had significantly severe baseline ARWMC scales in total (CDR-SB: 5.8 vs. 3.6, adjusted P = 0.04; CDR: 6.4 vs. 4.4, adjusted P = 0.04) and frontal area (CDR-SB: 2.4 vs. 1.2, adjusted P = 0.01; CDR: 2.4 vs. 1.7, adjusted P < 0.01) compared with those with no deterioration in psychometrics after adjustment for confounders. By contrast, among AD patients without hypertension, no significant differences in ARWMC scales were observed between patients with and without deterioration. Conclusion: The effect of cerebrovascular pathologies on AD progression between those with and without hypertension might differ. An interaction but not independent effect of hypertension and WMCs on the progression of AD is possible.

[P1-427]: AGE-RELATED WHITE MATTER CHANGES SCALE: NORMATIVE DATA ON 1,439 PERSONS

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P443-P443 ◽  
Author(s):  
Cristina Festari ◽  
Clarissa Ferrari ◽  
Valentina Nicolosi ◽  
Roberta Rossi ◽  
Daniele Altomare ◽  
...  
Keyword(s):  
White Matter ◽  
Normative Data ◽  
White Matter Changes ◽  
Age Related

Evaluation of Age-Related White Matter Changes Using Transcranial Doppler Ultrasonography

2011 ◽  
Vol 23 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Yun Yun Xiong ◽  
Vincent Mok ◽  
Adrian Wong ◽  
Thomas Leung ◽  
Xiang Yan Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Transcranial Doppler ◽  
Doppler Ultrasonography ◽  
Transcranial Doppler Ultrasonography ◽  
White Matter Changes ◽  
Age Related

scholarly journals Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes

Stroke ◽  
2009 ◽  
Vol 40 (10) ◽  
pp. 3191-3196 ◽  
Author(s):  
Glen Jickling ◽  
Abdul Salam ◽  
Askar Mohammad ◽  
Muhammad S. Hussain ◽  
James Scozzafava ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
White Matter Changes ◽  
Circulating Endothelial Progenitor Cells ◽  
Age Related

scholarly journals White matter changes and late-life depressive symptoms

2007 ◽  
Vol 191 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Andrew Teodorczuk ◽  
John T. O'Brien ◽  
Michael J. Firbank ◽  
Leonardo Pantoni ◽  
Anna Poggesi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
White Matter ◽  
Later Life ◽  
Temporal Association ◽  
Cross Sectional ◽  
White Matter Changes ◽  
Treatment And Prevention ◽  
Age Related

BackgroundEvidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear.AimsTo investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders.MethodIn a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, disability and depressive symptoms, were assessed at baseline. Clinical assessments were repeated at 1 year.ResultsUsing logistic regression analysis, severity of white matter changes was shown to independently and significantly predict depressive symptoms at 1 year after controlling for baseline depressive symptoms, quality of life and worsening disability (P<0.01).ConclusionsWhite matter changes pre-date and are associated with the development of depressive symptoms. This has implications for treatment and prevention of depression in later life.

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