scholarly journals Evaluation of Pharmacological Modification of Growth Hormone Secretagogue Receptor in a Mouse Model of Non-Obese Type 2 Diabetes Mellitus

2017 ◽  
Author(s):  
Rasha Mosa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Growth Hormone ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Pharmacological Modification

Co-Purification of Recombinant Modified Glucagon-Like and Glucose-Dependent Insulinotropic Peptide to Create a Two-Component Drug for the Treatment of Type 2 Diabetes Mellitus and Obesity

2021 ◽  
Vol 37 (6) ◽  
pp. 74-83
Author(s):  
A.Yu. Gorbunova ◽  
E.P. Sannikova ◽  
I.I. Gubaidullin ◽  
O.M. Ignatova ◽  
M.Yu. Kopaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Specific Activity ◽  
Two Component ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Insulinotropic Peptide

In addition to the previously developed recombinant modified human glucagon-like peptide 1 (rmglp1, Glypin), a recombinant modified human glucose-dependent insulinotropic peptide (RMGIP) has been obtained. A new universal reverse-phase HPLC technique has been proposed allowing quantitative analysis of rmGlp1 and rmGip separately and as part of a two-component preparation. The data show that the design of recombinant human rmGip according to the Glypine formula makes it possible to produce one-component and two-component preparations containing various rmGip and rmGlp1 protein ratios ranging from 1:0 to 20:1, using cell biomass samples mixed in predetermined proportions. Studies of human rmGip activity in a mouse model revealed reduced specific activity and signs of weak antagonistic effects. In this regard, there is a need for further study of human rmGip activity in a mouse model, including the use of alternative mouse or rat rmGip. type 2 diabetes mellitus; two-component drug, glucose-dependent insulinotropic peptide, glucagon-like peptide-1 The work was supported by the Internal Grant from National Research Center Kurchatov Institute.

scholarly journals Recombinant Human Insulin-Like Growth Factor-I Treatment Inhibits Gluconeogenesis in a Transgenic Mouse Model of Type 2 Diabetes Mellitus

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2619-2630 ◽  
Author(s):  
Patricia Pennisi ◽  
Oksana Gavrilova ◽  
Jennifer Setser-Portas ◽  
William Jou ◽  
Stefania Santopietro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Growth Factor ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Recombinant Human Insulin ◽  
Factor I

scholarly journals Type 2 Diabetes Mellitus in Obese Mouse Model Induced by Monosodium Glutamate

2006 ◽  
Vol 55 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Mitsunobu NAGATA ◽  
Wataru SUZUKI ◽  
Seiichi IIZUKA ◽  
Masahiro TABUCHI ◽  
Hirofumi MARUYAMA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Monosodium Glutamate ◽  
Obese Mouse

scholarly journals Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus

Diabetologia ◽  
2009 ◽  
Vol 52 (7) ◽  
pp. 1434-1441 ◽  
Author(s):  
Y. Kawashima ◽  
J. Chen ◽  
H. Sun ◽  
D. Lann ◽  
R. J. Hajjar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Apolipoprotein E
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