Development of functional human dendritic cell subsets in vitro and in vivo in hu/NOD/SCID chimeric mice : important implications in dentritic cell-based immunotherapy

2005 ◽  
Author(s):  
S. Fadilah Binti Abdul Wahid
Keyword(s):  
Dendritic Cell ◽  
Human Dendritic Cell ◽  
Chimeric Mice ◽  
Dendritic Cell Subsets ◽  
Dentritic Cell

IN VITRO AND IN VIVO INVESTIGATIONS ON THE EFFECTS OF CYCLOSPORINE ON HUMAN DENDRITIC CELL SUBSETS

2004 ◽  
Vol 78 ◽  
pp. 601-602
Author(s):  
S Ciesek ◽  
B P. Ringe ◽  
C P. Strassburg ◽  
J Klempnauer ◽  
M P. Manns ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Human Dendritic Cell ◽  
Dendritic Cell Subsets

scholarly journals High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo

2020 ◽  
Vol 11 ◽  
Author(s):  
Gaël Auray ◽  
Stephanie C. Talker ◽  
Irene Keller ◽  
Sylvie Python ◽  
Markus Gerber ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
High Resolution ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Dendritic Cell Subsets

In vivo generation of human dendritic cell subsets by Flt3 ligand

Blood ◽  
2000 ◽  
Vol 96 (3) ◽  
pp. 878-884 ◽  
Author(s):  
Eugene Maraskovsky ◽  
Elizabeth Daro ◽  
Eileen Roux ◽  
Mark Teepe ◽  
Charlie R. Maliszewski ◽  
...  
Keyword(s):  
T Cell Immunity ◽  
Human Dendritic Cell ◽  
Flt3 Ligand ◽  
Healthy Human ◽  
Cell Immunity ◽  
Human Volunteers ◽  
Immune Response Regulation ◽  
Dendritic Cell Subsets

Abstract Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro–generated DCs are representative of DCs that develop in vivo. Treatment of mice with human Flt3 ligand (FL) dramatically increases the number of DCs. We report here that administration of FL to healthy human volunteers increased the number of circulating CD11c+ IL-3Rlow DC (mean 44-fold) and CD11c− IL-3Rhigh DC precursors (mean 12-fold). Moreover, the CD11c+ DCs were efficient stimulators of T cells in vitro. Thus, FL can expand the number of circulating, functionally competent human DCs in vivo.

Inhibition of the proteasome influences murine and human dendritic cell development in vitro and in vivo

Immunobiology ◽  
2009 ◽  
Vol 214 (9-10) ◽  
pp. 843-851 ◽  
Author(s):  
Elisabeth Zinser ◽  
Susanne Rößner ◽  
Leonie Littmann ◽  
Daniel Lüftenegger ◽  
Ulrich Schubert ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Development ◽  
Human Dendritic Cell ◽  
Development In Vitro

Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors

Blood ◽  
2003 ◽  
Vol 102 (9) ◽  
pp. 3302-3310 ◽  
Author(s):  
A. Karolina Palucka ◽  
Joel Gatlin ◽  
Jean Philippe Blanck ◽  
Michael W. Melkus ◽  
Sandra Clayton ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Dendritic Cell ◽  
Scid Mice ◽  
Interferon Α ◽  
Human Dendritic Cell ◽  
Hematopoietic Progenitors ◽  
Human Cd34 ◽  
Plasmacytoid Dcs

AbstractDistinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34+ hematopoietic progenitors develop human myeloid and plasmacytoid DCs. The skin displays immature DCs expressing Langerin, while other tissues display interstitial DCs. Myeloid DCs from these mice induce proliferation of allogeneic CD4 T cells in vitro, and bone marrow human cells containing plasmacytoid DCs release interferon-α (IFN-α) upon influenza virus exposure. Injection of influenza virus into reconstituted mice triggers IFN-α release and maturation of mDCs. Thus, these mice may provide a model to study the pathophysiology of human DC subsets.

scholarly journals sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo

2019 ◽  
Vol 169 ◽  
pp. 111-120 ◽  
Author(s):  
Evelyne Schaeffer ◽  
Elena M. Sánchez-Fernández ◽  
Rita Gonçalves-Pereira ◽  
Vincent Flacher ◽  
Delphine Lamon ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Acute Inflammation ◽  
Human Dendritic Cell ◽  
Dendritic Cell Activation

scholarly journals BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo

2001 ◽  
Vol 31 (5) ◽  
pp. 1544-1549 ◽  
Author(s):  
Joost L. M. Vissers ◽  
Franca C. Hartgers ◽  
Ernst Lindhout ◽  
Carl G. Figdor ◽  
Gosse J. Adema
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Subsets

scholarly journals In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative

2015 ◽  
Vol 168 (2) ◽  
pp. 300-305 ◽  
Author(s):  
Maki Ushida ◽  
Tomonori Iyoda ◽  
Mitsuhiro Kanamori ◽  
Hiroshi Watarai ◽  
Kazuhiko Takahara ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Subsets
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